Clinical progress of engineered cellular immunotherapies for autoimmunity - Nature Biotechnology Engineered cellular immunotherapy shows great potential for treating autoimmune diseases. Payne and colleagues review emerging clinical data of the most recently developed technologies.

Engineered cellular immunotherapy shows great potential for treating autoimmune diseases. Payne and colleagues review emerging clinical data of the most recently developed technologies go.nature.com/4cvxe67
rdcu.be/feuuv

1/ Philipp Mallm from the @dkfz.bsky.social Single-cell Open Lab just broke the news at #AACR26: the first results on colorectal cancer (CRC) tissue analysis with the new Atera spatial transcriptomics platform from @10xgenomics.bsky.social. Is it "making the impossible possible?" 🧵

hahha, that must have been an autocorrect of whatever I typed instead of hoopla

Saw the big houplahoo about the "passing of the central dogma". Honestly, I don't really understand what the big deal is. An enzyme that can make a poly-dinucleotide. Great, a first, but is this really that surprising? And it has little to do with the flow of genetic information. What am I missing?

Love the cover!

Artificial allosteric protein switches with machine-learning-designed receptors - Nature Biotechnology Allosteric biosensors are constructed by combining reporter proteins with machine-learning-designed receptor domains.

Artificial allosteric protein switches with machine-learning-designed receptors - @arccoesb.bsky.social go.nature.com/4cshpM3

Zoe Mulford - "The President Sang Amazing Grace" YouTube video by World One Video

I have this song in my playlist, and every time it comes up, I'm struck how much the US has changed in the last 10 years

www.youtube.com/watch?v=2qdB...

Go work with Stefan. Great person and great place to work!

Hungary election live: Viktor Orbán concedes defeat in Hungarian election after 16 years in power Long-serving prime minister beaten by opposition after early results showed clear lead

Orban concedes defeat. The support of Trump, Vance, Putin, Lavrov, Weidel, Milei, Le Pen, Fico, Babis and many others could not overcome Hungarian anger at a stagnant, corrupt regime

www.theguardian.com/world/live/2...

Ohh, maybe not everything is bad!

Auszählungsstand Ungarn-Wahl, Stand: 21:23, 60,24% 136 Sitze für TISZA 56 Sitze für FIDESZ

2/3-Mehrheit 😊
Herzlichen Glückwunsch, 🇭🇺!
vtr.valasztas.hu/ogy2026?filt...

Trump says US will blockade strait of Hormuz after Iran peace talks fail Iran warns move would breach ceasefire as US president also repeats threats to strike critical infrastructure

I am really trying not to comment on politics. But sometimes it is hard not to despair:
www.theguardian.com/world/2026/a...

Detection of metastatic burden in mouse models should be done in 3D and at single-cell resolution.

The solution is CODA, a workflow that maps organs, tumors and mets exhaustively, in 3D, and at single-cell resolution.

Read about this here: www.biorxiv.org/content/10.6...

Got myself a gastrointestinal infection. Not recommended. Zero stars

Bioengineering symposium in Berlin!
We’re excited to co‑organize the Max Delbrück Center Bioengineering symposium on July 6, 2026.
Top speakers, poster awards, and great networking with the bioengineering community and Nature editors!
Info & registration: mdc-berlin.de/BioE-2026

Peritumoural adipose tissue drives immune evasion in colorectal cancer via adipose–mesenchymal transformation | Nature Cell Biology Although peritumoural visceral adipose tissue (tVAT) is anatomically close to tumours such as colorectal cancer, the immune landscape of this tissue and its functional contribution to tumour immunity remain poorly defined. Here, we performed single-cell RNA analysis on the tVAT from patients with colorectal cancer to map its immune landscape and observed that tVAT exhibited a highly immune-infiltrated microenvironment enriched with lymphocytes, especially tumour-specific CD8⁺ T cells. Mechanistically, tVAT competes with the tumour for these immunocytes by activating the CXCL12–CXCR4 axis to promote tumour immune escape. Moreover, tumour-derived factors induce an adipose–mesenchymal transformation process where the adipose stromal cells trans-differentiated into adipose-derived cancer-associated fibroblasts, which secrete large amounts of CXCL12 in tVAT. Clinically, targeting adipose–tumour interaction substantially enhances diagnostic and therapeutic efficacy of anti-PD-1 therapy. Thes

Colorectal cancer study finds peritumoural tissue key in immune evasion. High immune infiltration with CD8+ T cells noted. PMID:41714703, Nat Cell Biol 2026, @NatureCellBio https://doi.org/10.1038/s41556-026-01885-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

💯

PRET is a few-shot system for pan-cancer recognition without example training - Nature Cancer Li et al. present PRET, a few-shot system for pan-cancer detection not requiring model fine-tuning, validated it in multicenter datasets and found that it outperformed existing approaches across tasks...

Technical Report now published @natcancer.nature.com

'PRET is a few-shot system for pan-cancer recognition without example training'

By Xiaomeng Li, Kang Zhang, Qingling Zhang & colleagues

🔗 www.nature.com/articles/s43...

Single-cell and spatial profiling in cancer biology and clinical oncology - Nature Cancer Izar and colleagues review the insights into cancer biology gained via single-cell analyses and spatial profiling and overview the challenges and opportunities associated with the implementation of th...

New REVIEW published @natcancer.nature.com !

'Single-cell and spatial profiling in cancer biology and clinical oncology'

✏️By Benjamin Izar, Elham Azizi and co-authors

🔗 www.nature.com/articles/s43...

Patents on AI-derived drugs: empirical evidence and legal challenges - Nature Biotechnology Publicly available evidence regarding the impact of artificial intelligence on drug discovery is beginning to emerge, as patents on AI-derived drugs show evidence of scientific progress while revealin...

Publicly available evidence regarding the impact of artificial intelligence on drug discovery is beginning to emerge, as patents on AI-derived drugs show evidence of scientific progress while revealing new legal challenges go.nature.com/3Pw0osu
rdcu.be/fbY4b

Read so many of her papers as a PhD student and Postdoc
☹️

In memoriam: Catherine Rabouille (1962–2025) The cell biology community mourns the loss of Catherine Rabouille, an exceptional scientist whose determination, innovation, and fearless engagement with i

In memoriam: Catherine Rabouille (1962–2025) url: rupress.org/jcb/article/...

For Nature Biotechnology's 30th anniversary, we asked a selection of leaders from across biotech to look at the future of the sector and make some predictions for the coming years go.nature.com/4uR7pVa
rdcu.be/fbW5k

Programmable macromolecule delivery via engineered trogocytosis | Nature Cell Biology Trogocytosis, the transfer of plasma membrane fragments during cell–cell contact, offers potential for macromolecular delivery but is limited by the uncertain fate of trogocytosed molecules, restriction to membrane cargo and unclear generalizability. Here we demonstrate that donor cells engineered with designed receptors specific to surface ligands can transfer proteins to recipient cells through direct contact. We identified key engineering principles for enhancing transfer and ensuring cargo functionalization, including receptor design, pH-responsive membrane fusion, inducible cargo localization and release, and subcellular translocation. The method is broadly applicable across diverse cell types and operates through a dynamin- and endosome acidification-dependent pathway. Exploiting these findings, we developed TRANSFER, a versatile delivery system with programmable cell type specificity and tunability. TRANSFER can sense multiple ligand inputs, deliver large therapeutic protein car

New tech for macromolecule transfer: Engineered receptors enable direct protein delivery between cells via trogocytosis! #BiotechRevolution PMID:41922519, Nat Cell Biol 2026, @NatureCellBio @Stanford https://doi.org/10.1038/s41556-026-01920-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Every PI

Preparation of targeted lipid nanoparticles for precision nucleic acid delivery - Nature Protocols This protocol outlines the steps to prepare functionalized lipid nanoparticles covalently conjugated with whole antibodies or antibody fragments for targeted nucleic acid delivery to different tissues or cell types.

Great resource for everyone trying to targeted LNPs from Michael Mitchell's lab:
www.nature.com/articles/s41...

Our startup is looking for a technician.
Great place to work!
www.linkedin.com/jobs/view/43...

#SicherheitshalberLive

I am so happy to announce that my team at nBME is now complete! Looking forward to people getting to know Jelle, who has a great background in protein design and engineering and will be an invaluable asset to our team!

Internes Dokument der Uni Hamburg: Exzellenz-Uni muss drastisch schrumpfen Budget und Kosten der Uni Hamburg klaffen derart weit auseinander, dass die Streichung von Studiengängen droht. Denn auch die Rücklagen sind alle.

Nun trifft es die Uni Hamburg.

"Wie aus einem internen Dokument hervorgeht, das der taz vorliegt, gehen Budget und Kosten bis 2032 derart auseinander, dass ein Abbau von „10,5 %, 20 % oder noch mehr?“ erforderlich wird."

taz.de/Internes-Dok...