Doing the periodic cleaning of used plasmid miniprep columns and realized in honor of Earth Day it may be worth reminding you molecular biologists:
Plasmid miniprep columns can be cleaned and reused essentially indefinitely! Just add 1 M HCl, soak overnight and wash 3x w/ water. Save $ and plastic
Txp biopsy with rare probable cystine crystals in interstitial mononuclear cells in a patient with history of cystinosis. Rarely seen post-txp not clinically significant to my knowledge. #renalpath #pathsky #nephsky
One of many skin lesions removed. Standard level of Australian solar elastosis.
Invasive nests, vague peripheral palisading. #PathSky
We've updated our preprint characterizing the spatiotemporal impact of cold ischemia in mouse kidney to better understand the molecular underpinnings of cold-storage injury in kidney transplants.
Check it out: www.biorxiv.org/content/10.1...
🧵👇
Free text for days of the week -> imgs.xkcd.com/comics/explo...
It's not always just diabetic GS
Case of diabetic GS with chronic TMA 2/2 tyrosine kinase inhibitor (TKI)
🔸Anti-VEGF effects
🔸Most within weeks to months after starting TKI
🔸TMA +/- PAS+ pseudothrombi
pmc.ncbi.nlm.nih.gov/articles/PMC...
pubmed.ncbi.nlm.nih.gov/19054798/
#renalpath #pathsky
not many people know this, but Barilla has a line of 3D printed pasta it sells mostly to the fine dining industry. I don't want the pasta. I want the pasta printer
Image of the Week!
Contributed by: Aliya N. Husain, M.D.
Textbook topic: Lung
Diagnosis: Carcinosarcoma, lung
Textbook topic link: www.pathologyoutlines.com/topic/lungtu...
#Pathology #PathologyOutlines
Physicist has written a fascinating big beautiful paper.Let’s not be afraid to call it what it is - groundbreaking.
arxiv.org/abs/2603.21852
Renal biopsy demonstrated glomerulonephritis with focal immune deposits that stained exclusively for C3 (A and B), consistent with rapidly progressive glomerulonephritis (RPGN) due to C3 glomerulopathy
A 64 y/o woman was admitted for acute kidney injury w/ nephrotic range proteinuria. Prior, she had 3 months of duskiness of distal fingertips w/ mottling. Renal biopsy showed glomerulonephritis w/ focal immune deposits that stained exclusively for C3
Clinical images in ACROR
doi.org/10.1002/acr2...
Image Quiz! The tumor pictured is the most common salivary gland malignancy in the larynx. What is the diagnosis?
A. Adenoid cystic carcinoma
B. Epithelial myoepithelial carcinoma
C. Pleomorphic adenoma
D. Polymorphous adenocarcinoma
Answer linked in the comments.
#Pathology #PathologyOutlines
Congratulations to recent PMI graduate Morgan Jackson-Strong from the @gottschalklab.bsky.social on her new paper!
This Day in Labor History: April 14, 1975. The Bunker Hill Mining Company in Kellogg, Idaho announced a new policy in response to worries about female workers suffering reproductive problems due to lead exposure. They had to be sterilized to work!!!! Let's talk about this horrible policy!
#idboardreview 65 M s/p splenectomy 5yrs ago due to accident, from Connecticut admitted in July w/ 1wk of fevers, drenching sweats, fatigue, dark-colored urine, jaundice. Hb 8.5, plt 85k, Tbili 3.5, LDH 650, haptoflobin<10. Treatment? #idsky #idmeded #meded
Autopsy case with incidental ALECT2 amyloidosis with lung involvement. Essentially invisible by light microscopy. Wonder how often this is overlooked. 94% of cases had alveolar involvement in this study (PMID: 26912093). #pathksy #renalpath
Tol blue
This is either the biggest dork shit ever or beautiful or both.
Amazing: the viral pacers bickering couple were actually yakking about uh the Ben Sasse podcast and hashing out ways to rejigger liberal arts education www.si.com/nba/pacers/v...
Airmen of the 45th Weather Squadron prepare a weather balloon for launch as NASA, U.S. Navy, and U.S. Air Force teams continue to prepare for the the return of the Artemis II crewmembers to Earth, Wednesday, April 8, 2026, onboard USS John P. Murtha in the Pacific Ocean off the coast of California. NASA’s Artemis II mission is taking NASA astronauts Reid Wiseman, commander; Victor Glover, pilot; Christina Koch, mission specialist; and CSA (Canadian Space Agency) astronaut Jeremy Hansen, mission specialist on a 10-day journey around the Moon and back aboard their Orion spacecraft. Wiseman, Glover, Koch, and Hansen are scheduled to splash down off the coast of San Diego at approximately 5:07 p.m. PDT (8:07 p.m. EDT) on Friday, April 10. Photo Credit: (NASA/Joel Kowsky)
Lisa Seiler, Artemis Landing and Recovery Deputy Director, and airmen of the 45th Weather Squadron release a weather balloon for launch as NASA, U.S. Navy, and U.S. Air Force teams continue to prepare for the the return of the Artemis II crewmembers to Earth, Thursday, April 9, 2026, onboard USS John P. Murtha in the Pacific Ocean off the coast of California. NASA’s Artemis II mission is taking NASA astronauts Reid Wiseman, commander; Victor Glover, pilot; Christina Koch, mission specialist; and CSA (Canadian Space Agency) astronaut Jeremy Hansen, mission specialist on a 10-day journey around the Moon and back aboard their Orion spacecraft. Wiseman, Glover, Koch, and Hansen are scheduled to splash down off the coast of San Diego at approximately 5:07 p.m. PDT (8:07 p.m. EDT) on Friday, April 10. Photo Credit: (NASA/Bill Ingalls)
Support buoys are seen onboard USS John P. Murtha ahead of the return of the Artemis II crewmembers to Earth, Thursday, April 9, 2026, in the Pacific Ocean off the coast of California. NASA’s Artemis II mission is taking NASA astronauts Reid Wiseman, commander; Victor Glover, pilot; Christina Koch, mission specialist; and CSA (Canadian Space Agency) astronaut Jeremy Hansen, mission specialist on a 10-day journey around the Moon and back aboard their Orion spacecraft. Wiseman, Glover, Koch, and Hansen are scheduled to splash down off the coast of San Diego at approximately 5:07 p.m. PDT (8:07 p.m. EDT) on Friday, April 10. Photo Credit: (NASA/Bill Ingalls)
U.S. Navy MH-60 Seahawks from Helicopter Sea Combat Squadron (HSC) 23 are seen on the flight deck of USS John P. Murtha as they prepare to takeoff to conduct air operations training as NASA, U.S. Navy, and U.S. Air Force teams prepare for the the return of the Artemis II crewmembers to Earth, Tuesday, April 7, 2026, in the Pacific Ocean off the coast of California. NASA’s Artemis II mission is taking NASA astronauts Reid Wiseman, commander; Victor Glover, pilot; Christina Koch, mission specialist; and CSA (Canadian Space Agency) astronaut Jeremy Hansen, mission specialist on a 10-day journey around the Moon and back aboard their Orion spacecraft. Wiseman, Glover, Koch, and Hansen are scheduled to splash down off the coast of San Diego at approximately 5:07 p.m. PDT (8:07 p.m. EDT) on Friday, April 10. Photo Credit: (NASA/Bill Ingalls)
Artemis II Recovery Preparations
www.flickr.com/photos/nasah...
#Artemis 🧪🔭
A magazine ad featuring a black and white photo of a nerdy business man reacting to a sparkly trail looping around over his desk with the caption What the heck is Electronic Mail? One of the most advanced methods is terminals talking to one another. Text from Honeywell on the side invites you to contact Mr. Laurie Reeves by telephone to learn more.
old computing ads are amazing
The world's first view of Earth taken by a spacecraft from the vicinity of the Moon. The photo was transmitted to Earth by the United States Lunar Orbiter I and received at the NASA tracking station at Robledo De Chavela near Madrid, Spain. This crescent of the Earth was photographed August 23, 1966 at 16:35 GMT when the spacecraft was on its 16th orbit and just about to pass behind the Moon. Credit: NASA.
Earthset captured through the Orion spacecraft window at 6:41 p.m. EDT, April 6, 2026, during the Artemis II crew’s flyby of the Moon. A muted blue Earth with bright white clouds sets behind the cratered lunar surface. The dark portion of Earth is experiencing nighttime. On Earth’s day side, swirling clouds are visible over the Australia and Oceania region. In the foreground, Ohm crater has terraced edges and a flat floor interrupted by central peaks—formed when the surface rebounded upward during the impact that created the crater. Image Credit: NASA.
How it started, how it's going
Left: Lunar Orbiter I, 1966
Right: Artemis II, 2026
flic.kr/p/8Grtp2
flic.kr/p/2s68RXM
#Artemis 🧪🔭
two entoloma amongst ferns, and leaf litter
you guys have a gander at these cool blue mushrooms i saw 😊 werewere-kōkako (entoloma hochstetteri)
Metastasis in motion. Tumour tracking towards the already pretty chockers lymph node.
Shortlist of actors for TNG
![[alt text by NASA] The Moon, seen here backlit by the Sun during a solar eclipse on April 6, 2026, is photographed by one of the cameras on the Orion spacecraft’s solar array wings. Orion is visible in the foreground on the left. Earth is reflecting sunlight at the left edge of the Moon, which is slightly brighter than the rest of the disk. The bright spot visible just below the Moon’s bottom right edge is Saturn. Beyond that, the bright spot at the right edge of the image is Mars. Credit: NASA](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:62gdkmpwa7xme36getyqnem3/bafkreiakufyngycqogzws43gzq5ei2zayvoozx42wmbmyawywxyjqhw2ua)
[alt text by NASA] The Moon, seen here backlit by the Sun during a solar eclipse on April 6, 2026, is photographed by one of the cameras on the Orion spacecraft’s solar array wings. Orion is visible in the foreground on the left. Earth is reflecting sunlight at the left edge of the Moon, which is slightly brighter than the rest of the disk. The bright spot visible just below the Moon’s bottom right edge is Saturn. Beyond that, the bright spot at the right edge of the image is Mars. Credit: NASA
Whoa 🤯
The Moon, in full eclipse, with the #Artemis II Orion spacecraft. Part of the Moon and spacecraft are lit by Earthshine, and both Saturn and Mars are visible to the lower right. Incredible. Details: images.nasa.gov/details/art0...
On a black background of space, a blue and white Earth just before 'setting' behind the Moon, in foreground, seen from Artemis II, 6 April 2026
Totality seen from lunar orbit, the Moon eclipses the Sun, revealing a view few humans have ever witnessed, a dark disc surrounded by a pale solar corona.
✅ #Artemis II update: 'Earthset', 6 April 2026, and 'totality', 7 April, seen from lunar orbit, the Moon eclipses the Sun, a view few humans have ever witnessed (pics: NASA)
🔗 www.nasa.gov/gallery/jour...
@exploration.esa.int l
Rhinoceros
Racehorse of Dreams
Bruce Campbell and the Ant of Darkness
