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Posts by Robert Fledrich

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Meet the minds shaping GLIA 2027 (Bologna, Italy)! The PC will soon be selecting the most exciting symposia and plenary speakers for the GLIA 2027 congress.
Want to be part of the programme - submit your proposal: https://www.glia-meeting.eu/2027/call-for-symposia/

3 weeks ago 7 3 0 0
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Call for Symposium Proposals NOW OPEN | #Glia2027
Submit proposals for Symposia, Special Trainee and Technical Symposia covering all aspects of glial biology (CNS & PNS).
Deadline: 8 April 2026.
Details: www.glia-meeting.eu

#GlialCells #Astrocytes #Oligodendrocytes #Microglia #SchwannCells

3 months ago 8 4 0 0
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🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...

6 months ago 283 110 7 11
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Spatial lipidomics reveals demyelination and remyelination dynamics in the mouse brain Myelin pathology in demyelinating diseases is accompanied by lipid remodeling that remains challenging to characterize at spatial level using traditio…

Remyelinated fibers have a distinct lipid profile compared to intact myelin
www.sciencedirect.com/science/arti...

6 months ago 7 3 0 0
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Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...

8 months ago 345 130 31 23

What an outstanding piece of work - congratulations André!

7 months ago 1 0 1 0
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Multi-omic identification of perineurial hyperplasia and lipid-associated nerve macrophages in human polyneuropathies Nature Communications - Polyneuropathy causes are difficult to pinpoint. Here, authors used single-nucleus and spatial transcriptomics of 37 human peripheral nerves to identify focal perineurial...

Our paper was just published in Nat Comm. First single‑nucleus atlas of human sural nerves in health and disease. Identified lipid‑phagocytosing macrophages and focal perineurial hyperplasia especially in immune-mediated polyneuropathies. rdcu.be/eB2Dg

7 months ago 7 3 0 0
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How are human brain regions connected? Are the connecting axons thicker and more myelinated the longer these connecting fibers are?

In our recent paper we find that indeed, they are! Read the skeetorial below ⬇️⬇️⬇️

plos.io/4mq5tOy
#neuroscience #neuroskyence #whitematter #deeplearning

8 months ago 21 12 3 2
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Now published in the June issue @natneuro.nature.com
I am especially happy that the artwork my 4-year-old son created (with a little help) was chosen for the cover.
#Glial cells in diverse hues as paint splotches, CD8+ #Tcells in red, aberrant #myelin in purple.
Thanks @elisaflo.bsky.social & team!

10 months ago 11 3 1 0

Congratulations Janos! And fantastic art work by your little one!

10 months ago 1 0 0 0
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Universität Leipzig: GRK Neurotune

Do you want to explore the molecular secrets of how we adapt and learn?

We are excited to announce the launch of the interdisciplinary Research Training Group NeuroTune.

Applications for 10 PhD positions are now open!

#NeuroTune #DFG #Neuroscience #PhDOpportunities

1 year ago 2 2 0 0
Universität Leipzig: GRK Neurotune

🚀 Now hiring: 10 Doctoral Researchers @ Leipzig University! 🧠🔬

Join the DFG funded RTG NeuroTune and explore how neurons fine-tune communication!
📍 Start: Oct 1, 2025
🎯 Cutting-edge neuroscience + top-tier mentoring in vibrant Leipzig.

Apply now 👉 www.lw.uni-leipzig.de/en/institut-...
#NeuroTune

1 year ago 3 1 0 1

Can 2–4 hours of intense exercise really deplete brain myelin by nearly a third? Myelin water fraction isn’t the same as myelin, and this bold claim needs far more evidence. (Good thing marathon runners don’t seem to suffer cognitive issues!)

1 year ago 3 2 0 0
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The STRIPAK complex is required for radial sorting and laminin receptor expression in Schwann cells YAP/TAZ-mediated gene transcription is necessary for Schwann cell laminin receptor expression and differentiation. Weaver et al. use transgenic mouse models to show that the STRIPAK complex is required to regulate YAP/TAZ and facilitate radial sorting.…

The STRIPAK complex is required for radial sorting and laminin receptor expression in Schwann cells

1 year ago 2 3 0 0

Do women exhibit less cognitive decline because they can better maintain myelin due to Plp expression from the silent X chromosome?

1 year ago 2 1 1 0
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Get On Your Nerves LP (SouthPaw, 2010), by Myelin Sheaths 11 track album

Not sure what mental short circuit made me search for myelin on spotify, but I’m so glad I did. What I found reignited my old love for vinyl and garage punk and took me back to my student days when I had a band like this - ‚The Myelin Sheaths’ to me sound like a beautiful serendipity of fate.

1 year ago 4 0 1 0
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Wrapped up: advancements in volume electron microscopy and application in myelin research The three-dimensional visualization of cellular architecture by volume electron microscopy (vEM) has reignited interest in morphological descriptions of complex tissue. At the same time, the increasin...

Wrapped up: advancements in volume electron microscopy and application in myelin research

Glad to have contributed a bit to this review!

www.degruyter.com/document/doi...

1 year ago 15 7 0 0
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We are excited to present a first large-scale (365,708 nuclei) single cell atlas of human peripheral nerves combined with subcelullar spatial transcriptomics (#Xenium). A

www.biorxiv.org/content/11.1...
Explore: pns-atlas.mzhlab.com
A tweetorial 1/11

1 year ago 26 5 2 5

Thank you Minou :)

1 year ago 0 0 0 0

Thank you Gonçalo!

1 year ago 0 0 0 0

Big thanks!

1 year ago 0 0 0 0

Thanks Janos!

1 year ago 0 0 0 0

Thank you!

1 year ago 1 0 0 0
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ERC Consolidator Grant for research on nerve disorders Robert Fledrich, neuroscientist and professor at the Institute of Anatomy at Leipzig University’s Faculty of Medicine, has been awarded an ERC Consolidator Grant by the European Research Council (ERC)...

I'm over the moon to share that I have been awarded an ERC grant! 🎉✨ - can‘t wait to dive into super exiting projects! #ERCCoG

www.uni-leipzig.de/en/newsdetai...

1 year ago 11 1 5 0

Thank you! 😊

1 year ago 1 0 0 0
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Thank you Pete, I’m really looking forward to seeing you in Kassel!

1 year ago 1 0 0 0

Thank you Sophie & Yannick, it definitely is! 🎉

1 year ago 0 0 0 0
Universität Leipzig: Coming soon...

Thrilled that the DFG will fund our NeuroTune graduate school in Leipzig with €5.7M, supporting 5 tandem projects creating over 40 PhD positions. The Stassart/Fledrich lab is proud to host two projects, exploring adaptive myelination in diverse contexts. Stay #NeuroTuned for updates!

tiny.cc/3fyvzz

1 year ago 12 4 3 1

Here’s the #Schwanncell starter pack.

go.bsky.app/TXfQiG

1 year ago 13 7 7 0

Thank you Ethan! Please add us.

1 year ago 1 0 1 0