Our structure determination of a dopamine-binding DNA aptamer yielded surprising results. The structure had only 2 Watson-Crick base pairs, but lots of base pairs normally only seen in RNA folds. Check out our crazy DNA structure in the recent bioRxiv preprint, along with other binding details.

Functional relevance of CASP16 nucleic acid predictions as evaluated by structure providers www.biorxiv.org/content/10.1101/2025.04....

Welcome to the new Bluesky account for the Bordeaux RNA Club @rnabordeaux.bsky.social
We will soon be announcing details for the next symposium to be held 17-18 June.

Quantifying metabolites using structure-switching aptamers coupled to DNA sequencing - Nature Biotechnology Metabolites can be quantified using a combination of aptamers and DNA barcodes.

We are looking to hire:
1. Skilled molecular biologist, specific expertise in SELEX or aptamers
2. Computational biologist wanting to take deep seq training data to crack the aptamer-target prediction problem
My DMs are open - it is to drive this project forwards:

www.nature.com/articles/s41...

Now official: We have another opening for a fully funded #PhDposition in the Beusch lab (www.beuschlab.org) at @uniwuerzburg.bsky.social! More details here: tinyurl.com/947xcw85 If you or someone you know is curious about #splicing please apply or contact me for more information! #RNAsky #RNAbiology

Structural basis of Spliced Leader RNA recognition by the Trypanosoma brucei cap-binding complex - Nature Communications Bernhard et al. reveal the architecture of the tetrameric Trypanosoma brucei nuclear cap-binding complex. Using cryo-electron microscopy and biochemical assays, the researchers characterize its bindin...

Architecture and RNA binding properties of the trypanosome nuclear cap-binding complex - key complex in the parasite’s RNA metabolism. Final peer-reviewed version is public! #RNAsky #trypsky www.nature.com/articles/s41...

NMR research engineer - Uppsala University NMR research engineer , Disciplinary Domain of Science and Technology, Faculty of Chemistry, Department of Chemistry - BMC, Uppsala University

My NMR center is looking for a new staff scientist. It’s an amazing work environment at Uppsala University, Sweden.

Come join us!

www.uu.se/en/about-uu/...

I would be happy to join the list as well. We look at nucleic acid structures and protein-RNA complexes by NMR

Nice list! Can you add me as well?

It's been great working with the groups of @mazna.bsky.social and Davide Mercadante on this project. And already looking forward to the next experiments on eIF4B

First night at the yearly conference in the Swiss Alps after a lively poster session. The scenery is as pretty as always, and the snow this year looks great!

A Post Doctoral position is open in my team @AFMBLab . We are looking for motivated researchers to help us understanding viral replication mechanisms in membranes by emerging RNA viruses. See the call in here => www.afmb.univ-mrs.fr/offre-de-con...

Happy to share our research on using AlphaFold2 to predict how peptides from disordered regions bind proteins, just published in NatureComms
rdcu.be/dwlLa
Work done with Hélène Bret and Raphael Guerois and for the revised version with great contributions from @diegozea.bsky.social and Jinmei Gao.
🧬🧶

Chemical structures in 3 different sizes of spheres. Each sphere has a different label: 41393 CCDs, 1115 PRDs, 2745 CLCs.

Interested in small molecules 🧪 ⚗️ & 3D macromolecular structures? 'Accessing Enhanced Small Molecule Information in the Protein Data Bank in Europe' by @preeti_cy (Winter 2023 @RSC_CICAG Newsletter)
⬇️ Quick read ⬇️
www.rsccicag.org/newsletters....

Structure image in background with PDBe logo in green and red at bottom right corner and text in a circle in the centre that reads 'PDBe is a founding member of the wwPDB consortium' with a green banner with white text that reads 'wwPDB'

Structure image in background with PDBe-KB logo in green and red at bottom right corner and text in a circle in the centre that reads 'PDBe-KB is a consortium providing structural and functional annotation data' with a green banner with white text that reads 'PDBe-KB'

Structure image in background with a circle in the centre that reads 'AlphaFoldDB is a collaboration between EMBL-EBI and Google DeepMind' with a blue banner with white text that reads 'AlphaFoldDB'

Structure image in background with 3D-Beacons lighthouse design logo in green, red and grey at bottom right corner and text in a circle in the centre that reads 'The 3D-Beacons consortium provides a single access point for macromolecular structure data' with a green banner with white text that reads '3D-Beacons'

We’re delighted to have joined BlueSky to engage with the scientific community about macromolecular structures and related data. Follow us for updates on PDB and #AlphaFold DB databases, more info on our resources such as #PDBeKB, and for lots of beautiful structure images!