Hallmarks of aging contributing to inflammaging. Aging is accompanied by multiple interconnected cellular and molecular alterations, including genomic instability, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, and immune dysregulation that collectively drive chronic, low-grade inflammaging. Adapted with permission from Guimaraes et al.30
A summary of the NIH Aging and Trans-NIH Chronic Inflammation Working Group meeting, which explored recent advances and gaps in our understanding of the role of inflammaging in disease development, can be found in the Immunology Notes and Resources: https://ow.ly/OXcR50YNCJE