Come and join my group at @oxfordchemistry.bsky.social! We have an opening for a postdoc position in photopharmacology. Prior experience with photoswitches and photopharmacology essential. Deadline 27th April.
For more details see my.corehr.com/pls/uoxrecru...
#Chemsky
We're hiring a Postdoctoral Fellow!
How does Mycobacterium tuberculosis survive drug treatment? You'll use molecular genetics and single-cell approaches to investigate how gene expression variability drives drug-tolerant subpopulations.
Full details and application instructions below.
The latest AI/ML tools for co-folding proteins around small molecule ligands can produce impressive results.
Until you start looking at them closely.
Very excited to share our recently published work on NTM and their response to acid stress!
As my first paper, I’m especially grateful for the support and guidance from @luizcarvalholab.bsky.social , Rachel and @maxgg.bsky.social . More to come!
Are you interested in being the first biologist in our new team? Come join our small but growing group. Deadline for applications is 3rd March. #Tuberculosis 🧪🦠 #TBDrugDiscovery
I am happy to share our recent publication in @nature.com on a mucosal immunization strategy that clears C. difficile colonization in mice. Congratulations to Audrey Thomas, lead author on the work. www.nature.com/articles/s41...
📢 4-year PhD position in my lab at @crick.ac.uk
Using active learning & chemical genomics to find new antibiotics with new targets in pathogenic bacteria.
Looking for: chemistry / chem bio / comp bio / micro backgrounds with coding interest.
Deadline 17 March.
www.crick.ac.uk/careers-stud...
I’m looking forward to this incredible opportunity to advance the science of antibiotic discovery with the Gr-ADI consortium.
Congratulations! Amazing work.
FoldMason is out now in @science.org. It generates accurate multiple structure alignments for thousands of protein structures in seconds. Great work by Cameron L. M. Gilchrist and @milot.bsky.social.
📄 www.science.org/doi/10.1126/...
🌐 search.foldseek.com/foldmason
💾 github.com/steineggerla...
www.findaphd.com/phds/project... interested in bacterial antagonism? PhD opportunity in our team, see below. Please repost!
We’ve discovered how the superbug E. faecalis prevents chronic wounds from healing.
It’s not a toxin. It’s metabolism.
The bacteria use extracellular electron transport (EET) to electrochemically generate ROS, effectively "freezing" skin cells in place.
doi.org/10.1126/sciadv.aeb5297
I am looking for a postdoc to develop high-performance algorithms in computational genomics. Email or DM me if interested. For more information, see hlilab.github.io/vacancies. RTs appreciated!
Collaboration of AI and wet experiments with high thoughput technology is the one of solution IMHO.
Definitely on my festive reading list. Congratulations!
We’re excited to share our latest study that reshapes our understanding of Mycobacterium tuberculosis (Mtb) lipid composition, with major implications for drug discovery, immunity, and vaccine development.
www.nature.com/articles/s41...
A thread.
"Across the highest adult performance, peak performance is negatively correlated with early performance" Is uite literally what you'd see if coliderbias:
@peterfineran.bsky.social and colleagues develop Tn-seq for phages by leveraging anti-CRISPR (Acr) as a positive
selectable marker in the presence of CRISPR-Cas counter-selection, and identify essential genes in phage from non model orgs
www.biorxiv.org/content/10.6...
Multidisciplinary training, over time, produces the highest impact people
www.science.org/doi/10.1126/...
In case it's helpful, we've made a clean, open version here (along with several other cheminfo datasets). It hasn't been stress tested yet, so feedback on the cleanliness is welcome! huggingface.co/datasets/scb...
Light-activated metal complexes have been shown to disable antibiotic resistance enzymes in E. coli, significantly enhancing the effectiveness of existing antibiotics without harming human cells. doi.org/hbcxrb
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
🚨Deadline for our Senior Scientist applications is next week.
If you want to develop your academic career in London and help us tackle next-generation drug discovery for Gram-negative infections, apply!
Crick group leaders work across disciplines, supported by core funding and mentoring to build ambitious, curiosity-driven research.
Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
Just a few weeks left to apply for our clinical PhD programme.
We're looking for clinicians who are passionate about research to join the 3-year fully funded programme.
Learn more and see what positions are available ⬇️
www.crick.ac.uk/careers-and-...
📢 We're searching for a PhD-level Senior Research Scientist to develop a next-generation antibacterial drug discovery strategy for Gram-negative infections.
If you're looking to combine CRISPRi and high-throughput assays, reach out to me by email or apply below.
www.linkedin.com/jobs/view/43...
Join our community of more than 120 ambitious research programmes in infectious disease, chemical biology, and many other areas of biomedicine - all under one roof with fantastic facilities and support.
We are inviting applications for postdoctoral fellows in immunology of TB at the South African Tuberculosis Vaccine Initiative, University of Cape Town. For more information see the attached ad:
idm.uct.ac.za/media/739223
Dear #microbiology and #immunology community- I took a break from social media after I deleted my Twitter account, but am back here. Please help me rebuild my community by following me and amplifying this message- I will follow you back. Thank you and I look forward to our many interactions!
