Excited to share our paper about copick, a dataset API and toolkit for collaborative annotation and analysis of #cryoET data! Whether you're picking particles or curating segmentations, copick reduces friction and brings #OME-Zarr to cryoET without breaking pipelines.
🧵👇

doi.org/10.1002/pro.70578

Cell Bio 2023-An ASCB|EMBO Meeting Network, learn, and collaborate with top cell biologists from around the globe.

🚨Hear, hear, fellow microbial cell biologists!🚨
🦠 Bacterial and Archaeal Cell Biology will be represented again at this year’s CELL BIO (ASCB-EMBO) meeting! The deadline to be considered for a talk in our Minisymposium is June 9. Help us spread the word!
www.ascb.org/cellbio2026/

Congratulations Luke.. great news, and never in doubt!

An enhanced domestication method for uncultured bacteria Abstract. When environmental bacteria transition to laboratory conditions, a process termed domestication, the shift from the native habitat to a culture m

Most bacteria remain uncultured with vast microbial ‘dark matter’ awaiting discovery.. to address this am excited to share EDEN - an enhanced domestication method to grow uncultured bacteria & new diversity. Using EDEN we isolate a new species active against MDR pathogens..

doi.org/10.1093/isme...

Finally published. Many thanks to a wonderful collaborative team and scientific platforms!!! And thanks to editors and reviewers for enthusiasm and a great review.

www.nature.com/articles/s41...

An Asgard archaeon from a modern analog of ancient microbial mats A novel Asgard archaeon, Nerearchaeum marumarumayae, is present in microbial mats in Shark Bay, Australia. Combining genomic and structural analyses, together with high-resolution electron cryotomography, Nobs et al. reveal that these archaea possess unique cellular features that reflect their ancestry as progenitors of the earliest eukaryotic cells.

An Asgard archaeon from a modern analog of ancient microbial mats: Current Biology www.cell.com/current-biology/fulltext...

👀 a tad pilus machine feast.. 👏

Structural basis of supercoiling-induced CRISPR–Cas9 off-target activity - Nature Cas9 structures explain topology sensing and off-target activation.

1/11 In our story out today in @nature.com , we showcase the molecular mechanisms that enable Cas9 to bind and cleave negatively supercoiled ((-)SC) off-targets! 🧬🧵

🔗 www.nature.com/articles/s41...

#CRISPR #Cas9 #DNATopology #AFM #CryoEM #SingleMolecule #Biophysics

Great times!

We report the Pick fold and 2 variants thereof for tau filaments from individuals with MAPT mutations encoding for D252V, G272V, S320F and Delta_G389-I39, and we use these to reconstitute the Pick fold with recombinant tau in vitro. By @qcxy8886.bsky.social. 🥳

www.biorxiv.org/content/10.6...

👀 mystery solved for the Tad pilus one motor, two directions conundrum.. brilliant story, brilliant work.. 👏

crYOLO did us proud on our Vipp1 filaments.. none of the other programs worked as well. We had a mental toast to you at the time. Thanks for speaking out about this tough card you’ve been dealt. I’ll be thinking of you

Mapping the ultrastructural topology of septin cage entrapment

PhD studentship with @carolynmoores1.bsky.social

Direct link here: www.lshtm.ac.uk/study/fees-a...

Come work with Ben Berks FRS in Oxford
2 x PDRA posts: Molecular Analysis of Bacterial Outer Membrane Protein Biogenesis

2 complementary projects investigating bacterial outer membrane protein biogenesis. Building on our recent work (Nature (2015) 647: 479-487)

my.corehr.com/pls/uoxrecru...

Job opening for Research Group Leader in Structural Studies at MRC Laboratory of Molecular Biology, focusing on macromolecular structures.

Are you a structural biologist pushing the boundaries of molecular science with an ambitious research programme?
Join our Structural Studies Division as a tenure-track Group Leader, with core funding, world-leading facilities & enthusiastic colleagues.
Apply by 16 MAR
www.nature.com/naturecareer...

Our latest preprint: Together with the team of Jan Löwe, @danieltamarit.bsky.social and many others we discovered and characterized several Asgard tubulin genes and propose that microtubule architecture and dynamics evolved in Asgard archaea prior to eukaryogenesis
www.biorxiv.org/content/10.6...

Knockout pretty! Definitely worth the wait! 😉

A small polymerase ribozyme that can synthesize itself and its complementary strand The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?

Excited to share our latest work in @science.org on a new small polymerase.
1/n

❗️Highly recommended - please consider applying, 3 weeks to go👇🏻

Extremophile alert!

Registration is OPEN for the 2026 EMBO Archaeal workshop in Cambridge.

Spaces are limited, so register soon with an abstract if you’d like to give a talk.

If you can’t come in person, we are welcoming virtual attendees. So join us online where all talks will be screened!

We are looking for a new RA to join our team working on host-pathogen interactions during Salmonella infection. The appointment is for two years and you will join a diverse team, using cell and protein biochemistry to further our understanding of pathogenesis. my.corehr.com/pls/uoxrecru...

Join our division of Structural Studies at @mrclmb.bsky.social in the wonderful group of @suyangzhang.bsky.social!

Exploiting the bacterial DNA damage response as an alternative antimicrobial at Newcastle University on FindAPhD.com PhD Project - Exploiting the bacterial DNA damage response as an alternative antimicrobial at Newcastle University, listed on FindAPhD.com

E. coli is the leading bacterium causing death from AMR infections worldwide. If you'd like to explore approaches to exploit the DNA damage response as alternative antimicrobial, please apply to the following PhD studentship available in my lab starting October 2026: www.findaphd.com/phds/project...

Maybe that’s your next mission..

Alessandro Costa @costalaboratory.bsky.social, Dana Branzei and myself are co-organising the 2026 Machines on Genes meeting in beautiful Crete as the 94th Harden Conference hosted by @biochemsoc.bsky.social

Register now - lots of opportunities for selected talks www.eventsforce.net/biochemsoc/f...

Why solutions to antimicrobial resistance are urgently needed Summary: This Editorial discusses the growing global problem of antimicrobial resistance, and new and emerging opportunities for developing real-world solutions, involving both basic science and clini...

‘Why solutions to antimicrobial resistance are urgently needed‘ sergemostowylab.bsky.social & I had the opportunity to write an editorial for @dmmjournal.bsky.social ‘s collection celebrating 100 years of @biologists.bsky.social you can read it here: journals.biologists.com/dmm/article/...

🔬 Just out in @NatureComms!
Using cryo-CLEM and cryo-ET, we reveal the unique ultrastructure of dopaminergic varicosities in the striatum.
Amazing collaboration with @davip-bdx.bsky.social and Etienne Herzog @iins-bordeaux.bsky.social
Congratulations to Paul and Robin for this fantastic work! 🎉

IsoNet2 determines cellular structures at submolecular resolution without averaging www.biorxiv.org/content/10.64898/2025.12...

My excellent collaborator, Giulia Zanetti, is advertising for a post-doc to work on our shared MRC grant. Please consider applying to this great lab with a supportive mentor to do some exciting structural biology.
www.ucl.ac.uk/work-at-ucl/...

Polymyxins slow down lateral diffusion of proteins and lipopolysaccharide in the E. coli outer membrane - Communications Biology Multi-scale molecular dynamics simulations reveal that polymyxins form polymyxin-protein aggregates upon associating with the E. coli outer membrane thereby reducing lateral mobility of outer membrane...

Our paper on polymyxin interacting with the E. coli outer membrane is out! Simulations by the very talented @dheerajprakaash.bsky.social www.nature.com/articles/s42...

To scale outer membrane protein island simulated at coarse-grained resolution with portions refined at all atom resolution.