Out now in Nature Communications!
We show that Dictyostelium vaults associate with ER and NE membranes in situ and encapsulate ribosomes with defined orientations, shining new light on their cellular function! #TeamTomo #TeamMassSpec #ProtistsOnSky
www.nature.com/articles/s41...
New preprint 🚀 ❄️
We developed Autogrid-compatible HPF planchettes that enable direct freezing of clipped EM grids and streamline integration with cryo-FIB workflows
✔️ improved grid stability
✔️ reduced handling
✔️ robust vitrification (🦠 🧫 🧠)
A step toward routine HPF for complex samples
#teamtomo
Don't be shy to take on a little two-week side project. These five months will be the most precious three years of your academic journey.
Like most drug discovery researchers, I’ve been watching the “peptides for everything” craze with a mixture of amusement and alarm:
New preprint from the lab!
We developed a new tool to identify prokaryotic species (down to the strain level) directly from mass spectrometry-based bottom up proteomics data.
#teammassspec #microsky
www.biorxiv.org/content/10.6...
Sounds wonderful, honestly
Only 9 years to go from today, until AI cures all disease 🚀 🚀🚀
Really looking forward to it!
Happy Tax Day, New York. We’re taxing the rich.
Meta seems far less bothered by “fa” than by “antifa”
Wildlife trade drives animal-to-human pathogen transmission over 40 years
New in @science.org ‼️ In the most comprehensive study to date, we show that wildlife trade is driving animal-to-human zoonotic spillover at a planetary scale, with +1 spillover per host every 10 years. Live animal markets and illegal trade pose even greater risks. 🔓 www.science.org/doi/10.1126/...
Our paper describing the #cryoEM structures of unusual spike proteins from marine mammal–infecting gammacoronaviruses is now published in PLOS Pathogens! 🐬
journals.plos.org/plospathogen...
Meet our new #AllianceFellow Jack Whitehead!
The short interview about his work in the @chlandalab.bsky.social and Mahamid lab at @embl.org can be found on our LinkedIn account.
@jackwh18.bsky.social
Now THIS one was quite the journey. I'm beyond happy to see this work out in the world 🥹
Huge congrats to @computingcaitie.bsky.social and also to @hugovdhoek.bsky.social and everyone else involved ♥️
with @centriolelab.bsky.social @stearnslab.bsky.social @cellarchlab.com
#Cilia #CryoET #TeamTomo
I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...
Blender Rendering of vitrified HA trimer with DM at the air-water interface
We identified the maltoside detergent DM as an effective and easy solution to address preferred orientation in cryo-EM. Helped me switch from graphene grids. Special congrats to Maria Rafiq! @landerlab.bsky.social @nanigrotjahn.bsky.social @wisemanlab.bsky.social #cryoEM doi.org/10.64898/202...
Take a look at the fresh post-Easter paper about lipid regulation of NS5A, a key protein of the hepatitis C virus.
We were happy to contribute to the all-star team by Anna, Rebecca, James et al, spearheaded by Christoph Welsch.
www.science.org/doi/10.1126/...
If you know a graduating undergraduate looking for the chance to spend 1-2 years in a lab before graduate school, we're hiring! Our lab explores morphogenesis, defining how the cell adhesion & cytoskeletal machinery work together to allow cells to change shape & move tarheels.live/peiferlab/ 1/n RT
Are you excited by virology? Would you like to do a PhD? Three fantastic opportunities are available to do joint PhDs between @cvrinfo.bsky.social and @pirbrightinst.bsky.social
Details in the thread below - please share!
Deadline 8th May 2026, fully funded for UK Home students
(1/4)
Don't be absurd. We feed the title/abstract into ChatGPT and ask it to predict how many citations it'll pick up in the next two calendar years. If it's over 15 we accept it without bothering with peer review. /s
April's Molecule of the Month: Insect Odorant Receptors
These protein complexes allow insects to detect a wide variety of volatile compounds, from clove oil to DEET
Host cell remodeling via cyclin dependent kinases drives Ebola virus replication and transcription.
www.biorxiv.org/content/10.6...
Check out our latest preprint.
Great work by @tshamorkina.bsky.social. Thanks to co-authors Danni Snikkers and @hecklab.bsky.social
Structure of SARS-CoV-2 spike in complex with its co-receptor the neuronal cell adhesion protein contactin1
www.biorxiv.org/content/10.6...
Check out our new preprint. Cool structure by Sabrina Krepel with Bert Janssen.
Thanks to @danielhurdiss.bsky.social @utrechtvirology.bsky.social #covid #pais
👏
I don't think people fully appreciate how apocalyptic things are for US science. I haven't had any new funding since 2024, but I'm still ok since typical grants are for three years. This means next year I will be completely out of funding and will have to fire everyone in the lab. It's not great.
😂😂😂
