If you are interested in mitochondria, Nashville is the place to be June 1-5. Check out this FASEB meeting. Please RT. events.faseb.org/event/mitoch...

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📢 We have not 1 but 3 clinical/patient-facing jobs working with #mitoCAMB on the #LifeArc #raredisease centre for #mito diseases.

1x pre/post-doctoral CRA;
1x post-doctoral CRA (with potential to become a 4 year ACL); 1x research coordinator

Join us! Links below.

Woman scientist reading books.

Enjoy this week's selection of papers related to #MitochondrialDisease. Congrats to all the authors! 👇

biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitowomen.bsky.social @mitoworld.bsky.social @mitoscientists.bsky.social @mitoscientist.bsky.social

Mitofusin 2 displays fusion-independent roles in proteostasis surveillance

#mitochondrialdisease research from last week!
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoworld.bsky.social @mitowomen.bsky.social

Mitofusin 2 displays fusion-independent roles in proteostasis surveillance

Valeros et al, Rhodoquinone carries electrons in the mammalian electron transport chain

Groundbreaking week of research in #mitochondrialdisease!
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitowomen.bsky.social @mitoworld.bsky.social

Rhodoquinone carries electrons in the mammalian electron transport chain

Rogers and Mootha, Hypoxia as medicine

Start your week fresh with this outstanding collection of #mitochondrialdisease papers from last week!

biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitowomen.bsky.social @mitoworld.bsky.social

Hypoxia as medicine

A recent manuscript by @sulianamanley.bsky.social's lab led by @jclandoni.bsky.social describes reversible mitochondrial pearling as a driving force for mtDNA regular distribution within mitochondria.

PKmito ORANGE was used in to image mitochondrial pearling by STED microscopy in live cells.

SLC25A38 is required for mitochondrial pyridoxal 5’-phosphate (PLP) accumulation Nature Communications - Pyridoxal 5’-phosphate (PLP, vitamin B6) is crucial for various metabolic processes. Here, the authors identified SLC25A38 as a key regulator of mitochondrial PLP...

Here is a quick thread to promote my research! After years of dedicated research, I'm thrilled to share our article just published at Nature Communications :)

www.nature.com/articles/s41...

#metabolism #CRISPRscreens #mitochondria

Cancer cells ‘poison’ the immune system with tainted mitochondria Immune cells lose their cancer-fighting prowess after taking tumours’ organelles on board.

Really interesting paper 🧪 🤩

Immune evasion through mitochondrial transfer 😮

Ikeda et al find that #mitochondria from cancer cells can #transfer over to T cells - altering their #metabolism & reducing antitumour immunity

www.nature.com/articles/s41...

www.nature.com/articles/d41...

@nature.com

Muffels et al, Imaging flow cytometry reveals divergent mitochondrial phenotypes in mito disease patients

Last 2 weeks of research on #mitochondrialdisease!
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitowomen.bsky.social

Imaging flow cytometry reveals divergent mitochondrial phenotypes in mito disease patients

What a week for mtDNA and mito lovers!
@mitowomen.bsky.social

DLK-dependent axonal mitochondrial fission drives degeneration after axotomy Gomez-Deza et al

The first collection of papers on #mitochondrialdisease in 2025! @biomednews.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social @mitowomen.bsky.social @gavinmcstay.bsky.social

biomed.news/bims-mitdis/...

DLK-dependent axonal mitochondrial fission drives degeneration after axotomy

Preventing excessive autophagy protects from the pathology of mtDNA mutations in Drosophila melanogaster - Nature Communications Finding ways to compensate for mitochondrial dysfunction is essential. Here, the authors performed a genome-wide genetic screen to identify genes that mitigate the larvae lethal phenotype of a fruit f...

We are excited to share our latest work on mechanisms that protect from mitochondrial dysfunction. Thank you to all collaborators and the 4th anonymous reviewer for supporting us. @naturecomms.bsky.social
www.nature.com/articles/s41...

My lab at Emory University in vibrant Atlanta is looking for a postdoc candidate in #mitochondrialbiology and #metabolism! This position offers training opportunities in #metabolomics using our in-house Agilent 6546 QTOF LCMS. Please spread the word! (1/3)

THANK YOU for tagging us @docrock19.bsky.social!!

A glimpse beyond life and death: Exploring the biology of the MICOS complex See why MIC60, a part of the MICOS complex in mitochondria, is fatal when removed, as St. Jude researchers design mouse model to study mitochondrial disruption

🧪 St. Jude Progress has featured our research as part of their "Best of 2024", based on summary articles they wrote over the course of the year!

www.stjude.org/research/pro...

Let's start the week at Bluesky with an updated Starter Pack V3.0 #metabolism and #mitochondrialbiology are super strong here!

go.bsky.app/VavECSX

#Therapies for #mitochondrial #disorders community.

You are welcome to join by commenting below!

go.bsky.app/BnMQq9C

#therapy #mitochondria #mitochondrialdisease

HSF-1 promotes longevity through ubiquilin-1-dependent mitochondrial network remodelling - Nature Communications Increased activity of heat shock factor 1 (HSF1) promotes longevity; however, the mechanisms underlying this are unclear. Here, the authors show that in the nematode worm Caenorhabditis elegans, HSF1 ...

A long selection of papers this week related to #mitochondrialdisease

biomed.news/bims-mitdis/...

Many highlights, methods, emerging ideas.

Repost and follow for more mito-papers. 🦋

www.nature.com/articles/s41...

Hi all! We’re excited to see this community grow. One of our main goals is to highlight the work and voices of women in mitochondrial research. Please tag us in any relevant posts so we can help to amplify these contributions!!

Review title

Review sections graphic

Sub compartments of mitochondria graphic

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🔬 Curious about #mitochondria #imaging but unsure where to begin? Our review might help! 🚀📜🧪

www.annualreviews.org/content/jour...

#Quantitative #Microscopy #SuperResolution #AcademicSky #ScienceSky #CellBiology #mtDNA

The mitochondrial methylation potential gates mitoribosome assembly S-adenosylmethionine (SAM) is crucial for cellular processes, primarily serving as the principal methyl group donor of the cell and playing a key role in gene regulation and translation on the ribosom...

Exciting work from the #wredenberg Lab 🧪

www.biorxiv.org/content/10.1...

Deep learning-driven neuromorphogenesis screenings identify repurposable drugs for mitochondrial disease Mitochondrial disease encompasses untreatable conditions affecting tissues with high energy demands. A severe manifestation of mitochondrial disease is Leigh syndrome (Leigh), which causes defects in ...

In our latest preprint, we used brain organoids and machine learning to identify new drugs for the mitochondrial disease Leigh syndrome.
www.biorxiv.org/content/10.1...

Autophagic stress activates distinct compensatory secretory pathways in neurons Autophagic dysfunction is a hallmark of neurodegenerative disease, leaving neurons vulnerable to the accumulation of damaged organelles and proteins. However, the late onset of diseases suggests that ...

Excited to share this new preprint from Sierra Palumbos, tracking the effects of dysfunctional autophagy in neurons: www.biorxiv.org/content/10.1...

Events Aligning Science Across Parkinson’s (ASAP) aims to foster collaboration and discovery by supporting virtual and in-person events that facilitate connections and provide an avenue for sharing ideas. Se...

If you are interested in mitochondria, mitophagy and/or PD follow the mito911 Webinar series! Events calendar and registration at this link parkinsonsroadmap.org/events/

Links to multiple mitochondria and metabolism starter packs below!

Check out our new quick guide in @currentbiology.bsky.social, all about Mitochondrial Nucleoids! t.co/QFTQrevZNu

Check out these MITOchats on Thursday!! www.mitotalks.org for info and Zoom link.

We currently have 465 scientists in our database from across the globe.

Re-introducing ourselves to the Bluesky community! We aim to highlight research accomplishments performed by women in the field of mitochondrial biology. Also, visit our website, mitowomen.org, to find a list of women studying mitochondria. Please sign up if you haven't already!