Work led by me, @jjrosados.bsky.social , and @mtwhite.bsky.social. A great collaboration with @noeochida.bsky.social, @scauchemez.bsky.social , and colleagues across the @pasteur.fr network. (2/2)

Investigating antibody cross-reactivity and transmission dynamics of alphaviruses and flaviviruses using a multiplex serological assay - Nature Communications Arboviruses often co-circulate, but cross-reactivity hampers serological diagnostics. Here, the authors paired multiplex serology with competitive immunoassays and Bayesian modelling to quantify antib...

Excited to share our new paper out today in @natcomms.nature.com
Combining multiplex serology, mathematical modelling, and experimental validation reveals arbovirus transmission dynamics despite cross-reactivity. (1/2)

The final piece of my PhD work is now published in Science Translational Medicine! We present a new framework to jointly infer epidemiological and antigenic parameters from multi-pathogen population serological studies🦠

www.science.org/stoken/autho...

First new type of malaria treatment in decades shows promise against drug resistance If approved, GanLum could be available within a year and a half, according to maker.

In a clinical trial, this new malaria drug cured 97.4% participants

go.nature.com/3LGGZ6c

Whose line is it anyway? Defining sero-positivity cut-offs for infectious disease surveillance

✅ Just Accepted
#IDSky
🔗 https://bit.ly/4qoQdUq

From the now published pan-disease blood atlas, we used the proteomic data together with clinical and single-cell data to describe immune cross-talk linked with disease severity in malaria @cp-immunity.bsky.social

Check it out!

www.sciencedirect.com/science/arti...

#Immunology #malaria @ki.se

How a tick-borne virus enters human cells Tick-borne encephalitis virus can infect the nervous system and cause life-threatening illness. Finding the cellular gateway it uses could transform prevention and treatment.

Finding the tick-borne encephalitis cellular gateway could transform prevention and treatment

go.nature.com/3Kqp5E9

Dengue disease severity in humans is augmented by waning Japanese encephalitis virus immunity Waning immunity to Japanese encephalitis virus was associated with increased severity of dengue disease in a cohort of patients from Nepal.

A new analysis of a cohort in Nepal links the waning of vaccine immunity against Japanese encephalitis virus to elevated chymase levels and a higher risk of severe #dengue infection.

Read more in #ScienceTranslationalMedicine: https://scim.ag/45ORL27

Effectiveness of the TAK-003 dengue vaccine in adolescents during the 2024 outbreak in São Paulo, Brazil: a test-negative, case–control study TAK-003 was effective against symptomatic dengue and hospitalisation with dengue in adolescents during a large outbreak caused predominantly by dengue virus serotypes 1 and 2. These findings underscor...

New Research:

Effectiveness of the TAK-003 dengue vaccine in adolescents during the 2024 outbreak in São Paulo, Brazil: a test-negative, case–control study

www.thelancet.com/journals/lan...

Systems analysis of clinical malaria reveals proteomic perturbation and innate-adaptive crosstalk linked to disease severity While the immune response to Plasmodium falciparum malaria has been studied extensively, the circulating proteome and its cellular origins remain poorly characterized. Lautenbach et al. address this b...

Proud co‑author on @cp-immunity.bsky.social study by Julius Lautenbach, @chrissundling.bsky.social & Team Färnert w/ HPA & @scilifelab.se. We integrate plasma proteome dynamics (1500 proteins) + scRNA-seq in acute malaria, identifying severity markers & exploring immune-cell communication.

New-to-nature biocompatible chemistry for plastic waste upcycling - Nature Chemistry Synthetic and biological chemistry are traditionally seen as separate fields. Now, a biocompatible chemical reaction enables an engineered microbe to convert plastic waste into valuable compounds unde...

#NatMicroPicks

E. coli making paracetamol from plastic waste! 🦠💊

A new biocompatible chemistry for plastic waste upcycling using microbes.

#MicroSky #SynBio 🔧🧬

www.nature.com/articles/s41...

Great update on alphaviruses

Executive Summary of State-of-the-Art Review: Modern Approach to Nocardiosis—Diagnosis, Management, and Uncertainties Nocardia is a genus of gram-positive, partially acid-fast bacilli that typically infect people with chronic lung disease or immunocompromised states.

Executive Summary of State-of-the-Art Review: Modern Approach to Nocardiosis—Diagnosis, Management, and Uncertainties

⭐ Editor's Choice
#IDSky

Research in context panel from Lancet paper "Oral gepotidacin for the treatment of uncomplicated urogenital gonorrhoea (EAGLE-1): a phase 3 randomised, open-label, non-inferiority, multicentre study". Copyright: 2025 Elsevier Ltd. All rights are reserved.

Potential first new antibiotic for gonorrhoea since the 1990s is effective and safe, finds trial.

Explore the research ➡️ tinyurl.com/5bu2nbyt #ESCMID #ESCMIDGlobal

Beautiful study of primaquine treatment to prevent vivax malaria relapses from Jean Popovici's team from Pasteur Cambodia.

The study is special because patients were moved to a non-endemic part of Cambodia, excluding reinfection from msoquitoes.

authors.elsevier.com/sd/article/S...

A natural experiment on the effect of herpes zoster vaccination on dementia - Nature Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a follow-up period of 7 years by approximately one-fifth.

Nature research paper: A natural experiment on the effect of herpes zoster vaccination on dementia

https://go.nature.com/3XHRhq5

RSero: A user-friendly R package to reconstruct pathogen circulation history from seroprevalence studies Author summary Antibodies are immune markers of past infections. Seroprevalence studies that characterize the seropositivity status in the population have been used for decades in epidemiological stud...

Serological data provide key insights on pathogen circulation. We introduce a new R package, Rsero, which is a pipeline to store and analyze age-stratified sero data, estimate the history of pathogen circulation and compare different transmission models.
journals.plos.org/ploscompbiol...