Deep contrastive learning enables genome-wide virtual screening Recent breakthroughs in protein structure prediction have opened new avenues for genome-wide drug discovery, yet existing virtual screening methods remain computationally prohibitive. We present DrugC...

In a new Science study, researchers introduce DrugCLIP, a contrastive learning framework that virtually screens small molecules and protein pockets, analyzing protein-ligand interactions 10 million times faster than most standard molecular docking approaches. https://scim.ag/45FfSj2

📢Our latest issue is now online!

This month's issue is a special themed collection on Microbial Host & Metabolic Engineering for Natural Product Discovery & Production #secmet #natprod #chemsky

Read the articles in the collection on our website here🔽
pubs.rsc.org/en/journals/...

Introducing Nature Progress: a new series of fully open access journals designed to support work in dynamic and rapidly evolving research areas. Learn more: go.nature.com/4kNGB3w #ResearchPublishing

Stilbenoids from Vitis amurensis Bind to the GATA-3 DNA-Binding Domain and Inhibit the Transcription by GATA-3 GATA-3 serves as a key transcription factor driving Th2 cell differentiation and allergic cytokine production. Identifying the natural modulators of GATA-3 could provide therapeutic opportunities for the regulation of allergic responses. This study aimed to identify Vitis amurensis-derived natural products with strong GATA-3 inhibition and to elucidate their binding modes and mechanisms of action. The DNA-binding domain 2 (DBD2) of human GATA-3 was analyzed by using NMR spectroscopy, including backbone assignment. Isolated natural compounds were screened for binding activity, followed by reporter gene assays to evaluate the transcriptional inhibition potential. Two-dimensional NMR and docking studies were conducted to characterize binding interactions and identify binding sites. Stilbenoids from V. amurensis showed specific binding to the DNA-binding domain of GATA-3, as detected by 2D NMR. Reporter gene assays revealed dose-dependent transcriptional inhibition by these compounds. One of the hit compounds, KUP149, exhibited two binding modes on DBD2 based on NMR data, both of which can disrupt GATA-3–DNA interactions. These findings suggest stilbene-based natural products as potential inhibitors of allergic immune responses via GATA-3 modulation.

Stilbenoids from Vitis amurensis Bind to the GATA-3 DNA-Binding Domain and Inhibit the Transcription by GATA-3 | Journal of Natural Products pubs.acs.org/doi/10.1021/...

Natural products modulating interleukin-mediated pathways for anti-allergic and immunomodulatory effects Covering: upto 2025The increasing prevalence of allergic diseases and immunological disorders is a significant public health issue requiring the development of novel therapeutic approaches. Interleuki...

pubs.rsc.org/en/content/a...

Probiotic significance of Lactobacillus strains: a comprehensive review on health impacts, research gaps, and future prospects A rising corpus of research has shown the beneficial effects of probiotic Lactobacilli on human health, contributing to the growing popularity of these microorganisms in recent decades. The gastroi...

Full article: Probiotic significance of Lactobacillus strains: a comprehensive review on health impacts, research gaps, and future prospects

www.tandfonline.com/doi/full/10....

Therapeutic Potential of Ugonins: Bioactive Flavonoids from Helminthostachys zeylanica with Multifaceted Biological Activities

www.thieme-connect.com/products/ejo...

Response Surface Methodology Optimization on Ultrasonic‐Assisted Extraction of Chicory (Cichorium intybus L.) and Their UPLC‐ESI‐QTOF‐MS Analysis, Antioxidant and Hepatoprotective Activity - Baiseitova - 2025 - eFood - Wiley Online Library
iadns.onlinelibrary.wiley.com/doi/full/10....

Bacterial neuraminidase inhibitory chalcones from flowers of Coreopsis lanceolata, their kinetic characterization and antibiofilm effect Bacteria within biofilms are thousand times more resistant to antibiotics. Neuraminidase is a crucial enzyme for bacterial adhesion and biofilm format…

www.sciencedirect.com/science/arti...

Analogues of Dihydroflavonol and Flavone as Protein Tyrosine Phosphatase 1B Inhibitors from the Leaves of Artocarpus elasticus Protein tyrosine phosphatase 1B (PTP1B) is one of the target enzymes whose disruption leads to obesity and diabetes. A series of PTP1B inhibitors were isolated from the leaves of Artocarpus elasticus, used in traditional medicines for diabetes. The isolated inhibitors (1–13), including two new compounds (1 and 2), consisted of dihydroflavonols and flavones. The structural requirements for the PTP1B inhibitory mode and potency were revealed in both skeletons. The two highest PTP1B inhibitory properties were dihydroflavonol 1 and flavone 6 analogs with IC50 values of 0.17 and 0.79 μM, respectively. The stereochemistry also affected inhibitory potencies: trans isomer 1 (IC50= 0.17 μM) vs cis isomer 2 (IC50= 2.24 μM). Surprisingly, the dihydroflavonol and flavone glycosides (11 and 13) displayed potent inhibition with IC50s of 2.39 and 0.22 μM, respectively. Furthermore, competitive inhibitor 1 was applied to time-dependence experiments as a simple slow-binding inhibitor with parameters of Kiapp = 0.064103 μM, k3 = 0.2262 μM–1 min–1, and k4 = 0.0145 min–1. The binding affinities by using the fluorescence quenching experiment were highly correlated with inhibitory potencies: 1 (IC50= 0.17 μM, KSV = 0.4375 × 105 L·mol–1) vs 3 (IC50= 17.79 μM, KSV = 0.0006 × 105 L·mol–1). The specific binding interactions were estimated at active and allosteric sites according to the inhibitory mode by molecular docking.

Analogues of Dihydroflavonol and Flavone as Protein Tyrosine Phosphatase 1B Inhibitors from the Leaves of Artocarpus elasticus | ACS Omega pubs.acs.org/doi/full/10....

Ajania fastigiata in Zhetysu Alatau: Distribution, morphological characterization, phytochemical profiles, and optimization of extraction of bioactive constituents Despite the wide medicinal use of Ajania fastigiata (C. Winkl.) Poljakov. in folk medicine, most Ajania species from Central Asia have not been explor…

www.sciencedirect.com/science/arti...

www.frontiersin.org/journals/pla...

Response Surface Methodology Optimization on Ultrasonic‐Assisted Extraction of Chicory (Cichorium intybus L.) and Their UPLC‐ESI‐QTOF‐MS Analysis, Antioxidant and Hepatoprotective Activity - Baiseitova - 2025 - eFood - Wiley Online Library iadns.onlinelibrary.wiley.com/doi/full/10....

Stilbenoids from Vitis amurensis Bind to the GATA-3 DNA-Binding Domain and Inhibit the Transcription by GATA-3 GATA-3 serves as a key transcription factor driving Th2 cell differentiation and allergic cytokine production. Identifying the natural modulators of GATA-3 could provide therapeutic opportunities for the regulation of allergic responses. This study aimed to identify Vitis amurensis-derived natural products with strong GATA-3 inhibition and to elucidate their binding modes and mechanisms of action. The DNA-binding domain 2 (DBD2) of human GATA-3 was analyzed by using NMR spectroscopy, including backbone assignment. Isolated natural compounds were screened for binding activity, followed by reporter gene assays to evaluate the transcriptional inhibition potential. Two-dimensional NMR and docking studies were conducted to characterize binding interactions and identify binding sites. Stilbenoids from V. amurensis showed specific binding to the DNA-binding domain of GATA-3, as detected by 2D NMR. Reporter gene assays revealed dose-dependent transcriptional inhibition by these compounds. One of the hit compounds, KUP149, exhibited two binding modes on DBD2 based on NMR data, both of which can disrupt GATA-3–DNA interactions. These findings suggest stilbene-based natural products as potential inhibitors of allergic immune responses via GATA-3 modulation.

Our wonderful article has been published in Journal of Natural Product #acs #naturalproduct #GATA3
Stilbenoids from Vitis amurensis Bind to the GATA-3 DNA-Binding Domain and Inhibit the Transcription by GATA-3 | Journal of Natural Products pubs.acs.org/doi/10.1021/...

Solvent‐Dependent Bioactive Composition and Antifungal Potential of Neem (Azadirachta indica) Seed Extracts Against Mycotoxigenic Aspergillus Species Neem seed extracts show solvent-dependent bioactive profiles and strong antifungal activity against Aspergillus species. Ethanol and methanol extracts most effectively inhibit fungal growth and suppr...

My research, "Solvent‐Dependent Bioactive Composition and Antifungal Potential of Neem (Azadirachta indica) Seed Extracts Against Mycotoxigenic Aspergillus Species", has been published! Read it here: onlinelibrary.wiley.com/doi/10.1002/...

#publishedarticle Wiley In Research

Natural product inspired antibiotics approved for human use – 1943 to 2025 Covering literature to September 2025This review provides a comprehensive account of the 217 natural product inspired antibiotics that have been approved for human use from 1943 through to September 2...

Worth reading
@natprodreports.rsc.org
pubs.rsc.org/en/content/a...

Journal of Translational Medicine One of the world's leading journals in the field of translational research, Journal of Translational Medicine is dedicated to turning fundamental discoveries ...

Honored to join the Journal of Translational Medicine as an Associate Editor. Researchers in this area are welcome to submit their work and contribute to advancing translational science #springernature #translationalmedicine #associateeditor #research

link.springer.com/journal/12967

Ryanodane diterpenes: occurrence, structural diversity, bioactivities, and synthesis Covering: 1948 to 2025 Ryanodane diterpenes (RDs) are a unique class of plant-derived natural products characterized by their complex, polyoxygenated pentacyclic frameworks. They have been primarily…

Don't miss this review in our latest issue by Yu Zhang et al. from the Kunming Institute of Botany looking at the occurrence, structural diversity, bioactivities and synthesis of ryanodane diterpenes #natprod #secmet

Check out the full article below👇

Natural products modulating interleukin-mediated pathways for anti-allergic and immunomodulatory effects Covering: upto 2025The increasing prevalence of allergic diseases and immunological disorders is a significant public health issue requiring the development of novel therapeutic approaches. Interleuki...

I am pleased to share that, after one year, I have published my second review article in the well-reputed journal Natural Product Reports @natprodreports.rsc.org , @rsc.org

pubs.rsc.org/en/content/a...

Learn about the #neuroprotective capabilities of the charismatic #mangosteen in this review from our latest issue 🌟

www.thieme-connect.de/products/ejo...

#GrowingTogether #BrainHealth #MedicinalPlants #NeuroProtection

Natural Products Targeting Alzheimer’s Disease via NF-κB Pathway: A Review url:https://www.eurekaselect.com/article/151088

GLP-1-based therapies for diabetes, obesity and beyond Nature Reviews Drug Discovery - GLP-1-based therapies represent highly effective treatments for patients with type 2 diabetes and obesity. This Review profiles established and emerging GLP-1-based...

For readers interested in GLP-1-based therapies for diabetes, obesity and beyond, here's a recent review
rdcu.be/ePXoK
www.nature.com/articles/s41...

📖 Access this week's #FreetoRead article to learn more about an endangered species of fern with therapeutic potential 🌿
🔗 www.thieme-connect.de/products/ejo...

#GrowingTogether #MedicinalPlants #NaturalProducts

Thank you for sharing our incredible work

Metagenomics for Microbiology Metagenomics for Microbiology, Second Edition unveils the intricate and diverse world of microbial communities, emphasizing their critical roles in he

When you wear multiple hats, content designer, editor, and writer. Thank you to all contributors and the publisher @Elsevier.
#WritingCommunity #readingcommunity #booksky #editor
shop.elsevier.com/books/metage...

#humanmocrobiota #microbiome #peptide #nonpeptide
rdcu.be/ePihQ

Bacterial oxidoreductive enzymes as molecular weapons for the degradation and metabolism of the toxic azo dyes in wastewater: a review Azo dyes are extremely toxic and pose significant environmental and health risks. Consequently, mineralization and conversion to simple compounds are required to avoid their hazardous effects. A varie...

#bacterialoxidoreductive #enzymes #toxicazodyes #enviromentalchemistry
www.degruyterbrill.com/document/doi...

Our article in network pharmacology and molecular docking studies of chicory #networkpharmacology #moleculardocking #chicory #systembiology #glucosidase

www.mdpi.com/1422-0067/26...

Our review published after 2 years

Therapeutic Potential of Ugonins: Bioactive Flavonoids from Helminthostachys zeylanica with Multifaceted Biological Activities

www.thieme-connect.com/products/ejo...