Proud to share the culmination of a year’s work exploring anti-virulence strategies as a novel approach to combating antimicrobial resistance.

Many thanks to @doylemt1.bsky.social , @laurenceluu.bsky.social , and Richard Johnson (ECU) for their support and collaboration for this project! 😆

Very proud of both my students @itzfredz.bsky.social (Alfred Hartojo) and @alanaheisenhuth.bsky.social (Alanah Eisenhuth) for presenting their research at ASBMB2025. Also congrats to Alfred for his poster prize! 👏🏆

Mechanism of activation of contact-dependent growth inhibition tRNase toxin by the amino acid biogenesis factor CysK in the bacterial competition system Abstract. Contact-dependent growth inhibition (CDI) is a bacterial competition mechanism, wherein the C-terminal toxin domain of CdiA protein (CdiA-CT) is

Mechanism of activation of contact-dependent growth inhibition tRNase toxin by the amino acid biogenesis factor CysK in the bacterial competition system #tRNA2024 academic.oup.com/nar/article/... #rnasky #microsky

β-barrel membrane proteins fold via hybrid-barrel intermediate states Gram-negative bacteria and eukaryotic organelles of bacterial origin contain outer membrane proteins that possess a transmembrane “β-barrel” domain. T…

2) A review of membrane barrel folding by Alfred Hartojo (itzfredz.bsky.social) where he links steps of folding conserved between bacteria and mitochondria.

www.sciencedirect.com/science/arti...