#tRNA2024

Starting this platform with the excursion to the historic village Shirakawa-go. #tRNA2024 conference at Kanazawa, Japan

A bright red shinto shrine water basin with ladles for ritual purification, surrounded yellow ginko leaves on wet stone. It is raining.

The moss covered gardens of Kenroku-en. A small pagoda stands next to a torii gate on an island, its reflection visible in the water below.

The kotoji stone lantern balances at the edge of a pond. It’s a gray and cloudy day, but the maple trees have begun to turn red. In the distance, trees are tied in preparation for heavy winter snow using the traditional yukitsuri method.

The watchtower of Kanazawa castle sits on steep stone walls over a deep moat. Repeatedly destroyed by fire and reconstructed. The tower itself has a diamond shaped internal footprint with 80° and 100° angles, so it projects out sharply at this corner.

A perfect moody fall day in Kanazawa after the #tRNA2024 meeting.

Mechanism of activation of contact-dependent growth inhibition tRNase toxin by the amino acid biogenesis factor CysK in the bacterial competition system Abstract. Contact-dependent growth inhibition (CDI) is a bacterial competition mechanism, wherein the C-terminal toxin domain of CdiA protein (CdiA-CT) is

Mechanism of activation of contact-dependent growth inhibition tRNase toxin by the amino acid biogenesis factor CysK in the bacterial competition system #tRNA2024 academic.oup.com/nar/article/... #rnasky #microsky

Medicinal chemistry of benzo[d]isoxazole-4,7-dione analogues identifies the ribosomal small subunit as a target for specific mycobacterial translational fidelity Mycobacteria have high rates of error in the translation of glutamine and asparagine codons due to a two-step indirect tRNA aminoacylation pathway involving the essential amidotransferase GatCAB. This...

Medicinal chemistry of benzo[d]isoxazole-4,7-dione analogues identifies the ribosomal small subunit as a target for specific mycobacterial translational fidelity #tRNA2024 featuring aminoglycosides 🦠
www.biorxiv.org/content/10.1...

Functional redundancy in tRNA dihydrouridylation Abstract. Dihydrouridine (D) is a common modified base found predominantly in transfer RNA (tRNA). Despite its prevalence, the mechanisms underlying dihydr

Functional redundancy in tRNA dihydrouridylation #tRNA2024 #rnasky academic.oup.com/nar/article/...

Comparative analysis of 43 distinct RNA modifications by nanopore tRNA sequencing Transfer RNAs are the fundamental adapter molecules of protein synthesis and the most abundant and heterogeneous class of noncoding RNA molecules in cells. The study of tRNA repertoires remains challe...

Comparative analysis of 43 distinct RNA modifications by nanopore tRNA sequencing #tRNA2024 #rnasky www.biorxiv.org/content/10.1...

Homocysteine thiolactone from translation proofreading is an endogenous ligand for cell-cell signaling by the receptor SdiA Several widespread mechanisms enable cellular communication and coordinate the behavior of bacterial populations. The modules responsible for cellular communication are often found in matching pairs: ...

On methionyl tRNA synthetase (MetRS), homocysteine and bacterial communication 🦠 #tRNA2024 #RNAsky www.biorxiv.org/content/10.1...

Happily heading to the #tRNA2024 meeting in Kanazawa #rnasky