Thanks!

16S ribosomal RNA modification drives transcript-specific translation efficiency 🦠💫

16S ribosomal RNA modification drives transcript-specific translation efficiency 🦠 (rsmH)

#RNAsky #RNAbiology #RNAmodifications💫

Structure of a specialized 70S initiation complex Abstract. Bacteria of class Bacteroidia lack Shine-Dalgarno (SD) sequences and instead rely on other messenger RNA (mRNA) features, including upstream aden

academic.oup.com/nar/article/...

Excited to share our new paper out today in @science.org 🎉

We show that HGT via natural competence drives diversification of chromosomal integrons in V. cholerae 🤩

Below a 🧵 on key findings incl. background on natural competence in V. cholerae 1/
#microsky #phagesky
www.science.org/doi/10.1126/...

Structural adaptations for enhanced translation kinetics in evolved ribosomes 🦠www.biorxiv.org/content/10.64898/2026.03...

5-Azacytidine incorporation into mRNAs disrupts translation and induces ribosome collisions www.biorxiv.org/content/10.6...

Evolution of pandemic cholera at its global source - Nature The seventh cholera pandemic, driven by El Tor Vibrio cholerae, evolved separately in Bangladesh and India, with the Ganges Basin acting as the global source, and its evolution has been shaped by...

www.nature.com/articles/s41... Vibrio and its phage 🦠

A decade of antimicrobial resistance in Vibrio spp.: genomic and functional insights | Microbiology Spectrum This study highlights how long-term environmental and antimicrobial pressures shape the evolution of Vibrio species, leading to multidrug resistance and genomic diversification. By analyzing 16 years ...

doi.org/10.1128/spec...
🦠

Essentiality and dynamic expression of the human tRNA pool during viral infection - Molecular Systems Biology Human viruses rely on host translation resources, including the cellular tRNA pool, because they lack tRNA genes. Using tRNA sequencing, we profiled mature tRNAs during infections with human cytomegal...

link.springer.com/article/10.1... #rnasky

Landscape and dynamics of TadA-dependent RNA editing in Escherichia coli reveal a role in nutrient-rich growth | mBio Adenosine-to-inosine (A-to-I) mRNA editing is a recently discovered post-transcriptional mechanism in bacteria, yet its regulation and physiological roles remain poorly understood. In this study, we e...

doi.org/10.1128/mbio... 🦠 #rnasky

Interrogating the Escherichia coli epitranscriptome via CRISPR interference and Nanopore native RNA sequencing www.biorxiv.org/content/10.6...

Welcome! You are invited to join the following webinar: 2025 Westlake Science Symposia. After registration, you will receive a confirmation email with information on how to join the webinar. Ribosome heterogeneity is rapidly emerging as a transformative concept in molecular biology, challenging the long-standing view of the ribosome as a monolithic, generic protein factory. Accumulating d...

interesting webinar/symposium : Translational control by ribosome heterogeneity

us02web.zoom.us/webinar/regi...

Discovery - Superbugs: Resistance rising, part 1 - BBC Sounds Antibiotic resistant bacteria is rising - is a great global crisis on the horizon?

I finally had the chance to listen to @peaseroland.bsky.social's excellent documentary - Superbugs: Resistance Rising.

Highly recommended! Episode 1 is here www.bbc.co.uk/sounds/play/... or on your favourite podcast platform.

Direct RNA Sequencing Reveals Stress-Dependent and Pathway-Specific rRNA Modification Reprogramming during 50S Biogenesis Ribosomal RNA (rRNA) modification and processing are essential steps in the ribosome assembly. Using Oxford Nanopore direct RNA sequencing, we simultaneously detect and quantify N2-methyladenosine (m2...

Direct RNA Sequencing Reveals Stress-Dependent and Pathway-Specific rRNA Modification Reprogramming during 50S Biogenesis | Biochemistry 🦠 #rnasky #rnabiology pubs.acs.org/doi/10.1021/...

2′-O-Methylation maintains ribosome structural and translation integrity In eukaryotic ribosomes, ∼2% of RNA nucleotides undergo 2′-O-methylation, a conserved cellular mechanism thought to be critical for maintaining and re…

www.sciencedirect.com/science/arti...

The Landscape and Regulatory Determinants of A-to-I RNA Editing in Escherichia coli and Pseudomonas aeruginosa Isolated From Patients With Urinary Tract and Ear Infections Here, we describe the occurrence, regulatory features, and predicted effect of RNA-specific sequence changes resulting from A-to-I RNA editing in E. coli a

doi.org/10.1093/infd... A to I editing in clinical isolates during infection 💫🦠 #UTI #microsky #rnasky

Cool tool to capture genes using a hunter gatherer 🦠
Large-scale recovery of integron cassettes for gene discovery screens www.biorxiv.org/content/10.6...
by @jaescudero.bsky.social @afpcarvalho.bsky.social @filipatr.bsky.social

🌸🐟 RNA modifications Newsletter - April 2026 issue #10

🌸🐟 April RNA mods issue: reversible ac4C, Q-driven phenotypes, Ψ everywhere, grandpa ribosomes (aging ones), and translation quietly running the show (maybe the ribosome is the boss after all 👀) rnamodifupdates.substack.com/p/rna-modifi...

Rsfs dissociates vacant 70S ribosomes www.biorxiv.org/content/10.1... 🦠Bacteria adapt nutrient deprivation by reducing vacant 70S ribosomes via the silencing factor RsfS

Slowing the ribosome to allow survival in stressful conditiins www.biorxiv.org/content/10.6... The Helicobacter pylori ribosomal silencing factor RsfS is required for low-growth states and chronic infection 🦠

So happy to see this finally published in @plosbiology.org!

This is the first chapter of @julielebris.bsky.social PhD thesis demonstrating how capsules are exchanged by plug-and-play dynamics
w/ @epcrocha.bsky.social
#microsky @klebclub.bsky.social
Link below-
Check out her 🧵 for more details!

Permuted 23S rRNA is integrated in 50S ribosome particles in Thermococcus barophilus
www.biorxiv.org/content/10.6...

Unveiling hidden variables in stressed bacteria Noise in bacterial stress responses is often dismissed as mere randomness. While true stochasticity exists, much variation reflects hidden variables—cell state, history, and microenvironment—that are ...

Unveiling hidden variables in stressed bacteria: Cell Reports 🦠www.cell.com/cell-reports/fulltext/S2...

Mechanism of 30S subunit recognition and modification by the conserved bacterial ribosomal RNA methyltransferase RsmI | PNAS Ribosomal RNA (rRNA) modifications are important for ribosome function and can influence bacterial susceptibility to ribosome-targeting antibiotics...

Mechanism of 30S subunit recognition and modification by the conserved bacterial ribosomal RNA methyltransferase RsmI | PNAS 🦠🔥https://www.pnas.org/doi/10.1073/pnas.2523453123

Eukaryotic ribosomes also hibernate and SNORe.. identification of a new hibernation factor in yeast and fungi, which interacts with rRNA #ribosome 💫

Research Fellow (Postdoctoral) at University of Birmingham Explore an exciting academic career as a Research Fellow (Postdoctoral). Don't miss out on other academic jobs. Click to apply and explore more opportunities.

Two post-doctoral positions open in our lab. We're looking for people with expertise in molecular microbiology and/or genome-scale tools. Initially 3 yrs, posts could be extended for upto 8 yrs. If you'd like to know more about us take a look at www.graingerlab.com

www.jobs.ac.uk/job/DQY475/r...

Drought drives elevated antibiotic resistance across soils - Nature Microbiology Drought conditions in soil systems lead to elevated concentrations of natural antibiotics, as well as the enrichment of antibiotic-resistant microorganisms, highlighting a link between climate and the...

Drought drives elevated antibiotic resistance across soils

@natmicrobiol.nature.com from Dianne Newman
with @hannahjeckel.bsky.social

www.nature.com/articles/s41...

Mistranslation from an endogenous tRNA variant in human pan-genome cell lines doi.org/10.1093/nar/... " a natural genome-encoded human tRNA mutant causes mistranslation in cells derived from healthy individuals" with impact on modification and fragmentation
#RNAsky