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Posts by James N. Sleigh

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🚨 We’re Hiring! 🚨
Journal of Anatomy is looking for a new Editor-in-Chief to join one of the world’s most respected platforms in anatomical science.
Passionate about advancing scholarly research in the anatomical sciences?
Visit the link - tinyurl.com/znwubuu2

14 hours ago 2 2 0 0
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Brain-derived neurotrophic factor coordinates neuron-intrinsic programs to enhance axonal regeneration in human motor neurons BDNF promotes axon-regenerative gene expression, RNA metabolism, and kinase signaling in motor neurons.

Congrats to Jobert, Anna-Leigh, and Kai on showing how #BDNF amplifies #transcription, coordinates #RNA dynamics, and spatially regulates the #phosphoproteome.

Beautiful cover art too!

@jamessleigh.bsky.social @frattalab.bsky.social @uclqsion.bsky.social

1 week ago 21 11 0 0
Advert for BiO Global South travel grants, deadline 19 June 2026, with audience photo and a Biology Open logo

Advert for BiO Global South travel grants, deadline 19 June 2026, with audience photo and a Biology Open logo

BiO is pleased to launch a new grant: BiO Global South Conference Travel Grants, to help ECRs based in the Global South attend international biological and biomedical science conferences.
Next application deadline: 19 June 2026.
tinyurl.com/22zx7msy

3 weeks ago 9 10 0 1
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Download our database of free database of postdoc fellowships.

276 funding opportunities. For entry, we provide eligibility/requirements, amount, deadline, link, description, etc.

Download database here: research.jhu.edu/rdt/funding-...

1 month ago 37 28 0 1
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MitoTracker transfers from astrocytes to neurons independently of mitochondria The mitochondrial dye MitoTracker is commonly used to investigate intercellular mitochondrial transfer (IMT), particularly between astrocytes and neurons. Hole et al. compare MitoTracker with a geneti...

⚡️We are excited to share a new paper from the lab by @drkhole.bsky.social in @cp-cellrepmethods.bsky.social - suggesting MitoTracker dyes are not a reliable tool for detecting intercellular mitochondrial transfer❗️ www.cell.com/cell-reports...

1 month ago 41 24 1 2
An image montage advertising NeuroBioUK - 11th of September 2026 in York. The image is York cathedral superimposed over a fluorescent cortex mouse section coloured to look a bit like a dawn sky.

An image montage advertising NeuroBioUK - 11th of September 2026 in York. The image is York cathedral superimposed over a fluorescent cortex mouse section coloured to look a bit like a dawn sky.

Save the date for #NeuroBioUK26

Do you like neurons? Maybe glia? Molecules? Cell biology? - The venue is booked and we are excited to see you and your incredible science there on the 11th of September! Please do join our email list to stay up to date.

neurobiouk.sites.sheffield.ac.uk

1 month ago 16 11 0 1
Here, we make historic breakthroughs in Alzheimer's
Here, we make historic breakthroughs in Alzheimer's YouTube video by UCL Advancement

A wonderful video as part of #UCL200 - demonstrating what can be achieved when scientists work in partnership with the people impacted by disease. Carol Jennings was a phenomenal woman & that legacy continues

www.youtube.com/watch?v=L9Qo...

1 month ago 5 3 0 0
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Looking for a review on #BDNF in neurological disease?

Dr. Aurélie Paulo-Ramos has reviewed the latest info on its role in CNS and PNS neuropathologies for you:

portlandpress.com/biochemsoctr...

@dvillarroelc.bsky.social @uclqsion.bsky.social @uclqsneuromuscular.bsky.social #neurotrophins

1 month ago 5 2 0 0
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PhD Studentship: Genetic Modifiers to Untangle Disease Mechanisms of RFC1 Repeat Expansion at UCL Institute of Neurology jobs.ac.uk now advertising a PhD Studentship: Genetic Modifiers to Untangle Disease Mechanisms of RFC1 Repeat Expansion Visit jobs.ac.uk to apply and to browse more PhD opportunities.

A fantastic opportunity to join the team of Professor Andrea Cortese at UCL Queen Square Institute of Neurology, as a PhD student to work on genetic modifiers of RFC1 repeat expansion-associated CANVAS

The PhD is funded for 3 years, deadline 28th Feb.

www.jobs.ac.uk/job/DQK678/p...

2 months ago 3 4 0 0
Figure showing transport dynamics of LAMP1- and LAMP2A-positive organelles.

Figure showing transport dynamics of LAMP1- and LAMP2A-positive organelles.

Reem Abouward, Giampietro Schiavo & team find that LAMP1 and LAMP2A localise to distinct axonal organelles with differential transport dynamics, but share overlapping total protein compositions.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...

2 months ago 14 7 1 0
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Here, it will happen
Here, it will happen YouTube video by UCL Advancement

www.youtube.com/watch?v=BsSX...

2 months ago 4 2 0 0
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Neurotrophin-containing signalling endosomes travel from the distal axon to the soma. ALS-linked kinase TBK1 governs the directionality of their transport in motor neurons by phosphorylating Rab7.
www.life-science-alliance.org/content/9/4/...

2 months ago 2 3 0 1

The peer reviewed and updated version of this work is now online (although not quite the fully formatted version). We had an existential crisis about kinesin-1 regulation while developing this work, but we are super proud of everything we put into this project. www.cell.com/iscience/ful...

2 months ago 37 13 2 0
How chasing a high-impact publication nearly broke me “Looking back, I’m not sure it was worth the sacrifice,” this scientist writes

"I might not have felt the need to step away from academia had we aimed for a lower impact journal...success isn’t solely a matter of high-impact papers...its tracing a path that isn’t defined by what others expect of me"

www.science.org/content/arti...

2 months ago 8 3 1 0
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Learn about #axon regulation in the EMBO | The Company of Biologists Workshop "Axonal degeneration and regeneration" in Onna-son, JP, 18–22 Oct.

Abstract submission/Registration by 31 May/15 Jun

https://meetings.embo.org/event/26-axonal-degeneration
#EMBOAxonalRegeneration #EMBOevents #meeting 🧪

3 months ago 24 10 0 0
Axonal degeneration and regeneration Neurons are the largest and most long-lived class of cells, necessitating specialized mechanisms for their survival, growth and maintenance. Axons are the longest extensions of a neuron, reaching len…

🧪 An EMBO Meeting on Axon Biology in Okinawa, Japan

Iconic science at an amazing venue. Please join us!

EMBO | COB Workshop on Axonal degeneration and regeneration

meetings.embo.org/event/26-axo...

3 months ago 15 11 0 0
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My team are running the Peripheral Nerve Society's Instagram account this week: www.instagram.com/pnsociety1

If you like images of the nervous system, please check it out!

#FluorescenceFriday
@uclqsneuromuscular.bsky.social
@uclqsion.bsky.social

4 months ago 41 11 0 0
UCL Queen Square Institute of Neurology hosts Neuromuscular Diseases Research Day 2025 The latest Neuromuscular Diseases (NMD) Research Day took place in November 2025, bringing together clinicians, researchers, and partners to strengthen the future of NMD research.

UCL Queen Square Institute of Neurology Hosts Neuromuscular Diseases Research Day 2025. A fantastic day bringing together clinicians, researchers and trainees to share insights and celebrate progress in NMD research. 🧠
@uclqsion.bsky.social @uclbrainscience.bsky.social
Read more: bit.ly/48N8tPI

4 months ago 8 6 0 0
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Interview with Professor Giampietro Schiavo ABSTRACT. Giampietro Schiavo is a Professor of Cellular Neuroscience, Deputy Director for strategy at Queen Square Institute of Neurology, academic lead of the Alzheimer Research UK Drug Discovery Ins...

Didn't realize Gipi (Giampietro Schiavo) was Neuro Editor @jcellsci.bsky.social longer than I have had a lab...: journals.biologists.com/jcs/article/...

5 months ago 16 6 0 0
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Do all #NTFs regulate #MotorNeuron axonal transport in vivo?

Our new preprint shows they do not.

#BDNF enhances (shorturl.at/siwFi), #CNTF slows, and #HGF, #NRTN & #proBDNF show no effect.

#AxonalTransport regulation is selective, not universal.

@jamessleigh.bsky.social @uclqsion.bsky.social

6 months ago 14 4 0 0
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Deletion of murine Sarm1 results in a microenvironment that delays peripheral nerve regeneration after injury In Sarm1-deficient mice, peripheral nervous system regeneration is delayed after injury.

Paper Alert!! Our collaborative work with Giger Lab at UMich is out now in #ScienceTranslationMedicine Deletion of murine Sarm1 results in a microenvironment that delays peripheral nerve regeneration after injury | Science Translational Medicine @science.org
www.science.org/doi/10.1126/...

6 months ago 30 10 0 1
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How much of what we think we ‘know’ is just trust in the person that told us?

And what price do we pay for confusing the two?

Coming soon in Science Without Anguish:

‘Don’t believe everything you think!’

sciencewithoutanguish.com

Starts Monday 22nd Sep

7 months ago 7 3 0 0
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Beautiful data from @dvillarroelc.bsky.social showing a key role for TBK1 in #AxonalTransport of signalling endosomes:

www.biorxiv.org/content/10.1...

@uclqsion.bsky.social @mndassoc.bsky.social #ALS #MND

7 months ago 8 5 0 0

See you tomorrow - looking forward to your talk!

7 months ago 1 0 0 0
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NeuroBioUK - Programme 9 AM Arrival, registration & coffee Session 1: Organelle and synaptic signalling Session Chair: 9:45 AM Introduction 9:50 AM Sally Horton, The Francis Crick Institute, "CDKL5 in synaptic formation,...

The programme is up for #NeuroBioUK25 - take a look! And don’t forget to register by the 3rd of September…. neurobiouk.sites.sheffield.ac.uk/programme

7 months ago 15 5 1 3

Thank you, Rob!

8 months ago 0 0 0 0
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Senior Academic and Early Career Promotions 2024-25 Huge congratulations to the UCL Queen Square Institute of Neurology staff who have been awarded a promotion in this year's promotions round.

It's an honour to become a Professor at such a wonderful institution @uclqsion.bsky.social @uclbrainscience.bsky.social. The @uclqsneuromuscular.bsky.social is an amazing place to work and I couldn't have done it without my fantastic team, mentors and collaborators:

www.ucl.ac.uk/brain-scienc...

8 months ago 22 2 3 1
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The CCL2-CCR2 axis drives neuromuscular denervation in amyotrophic lateral sclerosis Nature Communications - Neuromuscular junctions (NMJs) are denervated in amyotrophic lateral sclerosis (ALS) through unknown mechanisms. Here, the authors show immune cells infiltrating muscle of...

🚨 New #ALS #MND publication from our lab (co-lead @drchayts.bsky.social), in collaboration with Bernát Nógrádi and colleagues from Hungary and Sonia Alonso-Martin and colleagues from Spain, just published in @natcomms.nature.com -> rdcu.be/eyNIs

8 months ago 10 5 1 0

Next UCL ALS-FTD Network Seminars - 25 July at 4pm, Gilliatt LT, QSH.

'Investigating pathomechanisms in Charcot-Marie-Tooth disease using mouse models and iPSCs'

'Generation of a universal human cellular platform for drug testing in ALS'

'A forebrain organoid model of progranulin-associated FTD'

9 months ago 2 2 0 1
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Microtubule curling as an efficient readout to uncover fundamental concepts of axonal

doi.org/10.1101/2025...

9 months ago 6 1 0 0