Excited to share our work on epithelial multilayering - identifying why stem cell stay in the basal layer and how and why differentiating cells move up. Great collab with @manningresearch.bsky.social and Niessen labs! Check out preprint and great summary below www.biorxiv.org/content/10.6...

www.nature.com/articles/s41...

Might be a bit late in the day....but if anyone fancies seeing the wonderful Black Rebel Motorcycle Club at the O2 Academy in Bristol tomorrow night (16th December) we have 2 tickets available:

secure.ticketmaster.co.uk/rs/3E00629C0...

Unfortunately, we can't make the trip up from Plymouth now!!

Regulation of cell dynamics by rapid #integrin transport through the biosynthetic pathway. New study from Martina Lerche, Mathilde Mathieu, Johanna Ivaska @johannaivaska.bsky.social @ivaskalab.bsky.social @turkubioscience.bsky.social and colleagues: rupress.org/jcb/article/...

#Adhesion #Cancer

Myself and @bmcarroll.bsky.social have a fully funded PhD studentship available to apply for through the SWBiociences DTP "Defining a role for mTORC1 in regulating focal adhesions and cell migration"

It's a great opportunity to work on an exciting project!

www.swbio.ac.uk/molecular-me...

Noooooo!!! Hope the trip went well though.

@vgelfand.bsky.social et al. use single-particle tracking to show #vimentin intermediate filaments display active movement throughout the cell, w/ individual filaments w/in a bundle moving independently rupress.org/jcb/article/...

📕 Intermediate Filaments collection: rupress.org/jcb/collecti...

The integrin odyssey – a journey full of fundamental discoveries Summary: This Perspective highlights the key discoveries in integrin research that laid the foundation for a successful field.

“The integrin odyssey – a journey full of fundamental discoveries” by Fässler and Sonnenberg in @jcellsci.bsky.social, worth a read!
journals.biologists.com/jcs/article/...

Description Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.

Deadline 15th October. Get in touch if you have any questions.

Please repost!

More details:
www.imperial.ac.uk/jobs/search-...

Mechanobiology of the blood-brain barrier during development, disease and ageing - Nature Communications The mechanobiology of blood brain barrier (BBB) remains underexplored. In this perspective, the authors highlight the emerging importance of mechanical forces in shaping BBB function across developmen...

Mechanobiology of the blood-brain barrier during development, disease and ageing
www.nature.com/articles/s41...

Actin-modulated nuclear shape controls adaptive reprogramming in cancer-associated fibroblasts Cancer-associated fibroblasts (CAFs) adapt to external cues such as therapeutic agents and extracellular matrix (ECM) stiffness in the tumor microenvironment (TME) through a reprogramming process. Her...

www.biorxiv.org/content/10.1...

Thompson, Stevenson et al @bristoluni.bsky.social show that two cis-Golgi golgins, GMAP210 & Golgin-160, have distinct roles in maintaining #Golgi organization & that both are required to support the efficient secretion, assembly, and modification of ECM proteins rupress.org/jcb/article/...

Fibrous polyisocyanide hydrogels for 3D cell culture applications - Nature Protocols Methods to use polyisocyanide as a model matrix for 3D cell culture. Polyisocyanide gels closely mimic the physical properties of biogels such as collagen and fibrin and, as fully synthetic materials,...

Hydrogels are essential in mechanobiology—and PIC is a game changer.
Fully synthetic yet highly biomimetic, PIC opens new possibilities for 3D cell culture applications.
Congrats to Hongbo Yuan, Kouwer Lab, and rochalab.bsky.social on this detailed Nature Protocols guide! 👏📜

. @mankie06.bsky.social, Michael Jones, Matthew Hartshorn, Patrick Caswell @integrintraffic.bsky.social & @drmcjones.bsky.social identify differential roles of cyclin–CDK1 complexes in cell migration and invasion. journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...

EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different c…

Excited to share our most recent study on #integrintraffic #cancer #migration #focaladhesion by @ivaskalab.bsky.social @drpaulinamoreno.bsky.social Niklas Jäntti et al www.sciencedirect.com/science/arti...

Great to have this collaboration with @drmcjones.bsky.social and @mankie06.bsky.social out! Differential roles of cyclin–CDK1 complexes in cell migration and invasion url: journals.biologists.com/jcs/article/...

Differential roles of cyclin–CDK1 complexes in cell migration and invasion Highlighted Article: Cyclin–CDK1 complexes have a previously undiscovered role in regulating normal and cancer cell migration in 3D matrices.

Pleased that our latest paper is now out in @jcellsci.bsky.social, in collaboration with @drmcjones.bsky.social and others from Manchester and Plymouth: Differential roles of cyclin–CDK1 complexes in cell migration and invasion url: journals.biologists.com/jcs/article/...

Outside influences: The impact of extracellular matrix mechanics on cell migration “No cell is an island” – highlights the interconnectedness of cellular behavior and the extracellular matrix (ECM). Cell migration is inherently conte…

Chapter Two - Outside influences: The impact of extracellular matrix mechanics on cell migration
www.sciencedirect.com/science/arti...

- A postdoc to work on cancer extravasation (4-year project).
- A postdoc help in completing Filopodia-related lab projects (2-year).
- Multiple Marie Curie postdoc positions that will open in the fall.
- We will open a 5-year position to cover my teaching (70% research and 30% teaching).

Thanks very much! Some great work from @mankie06.bsky.social and Mike Jones (my first PhD student).

Are you looking for a postdoc?
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!

2nd International Conference Focused on Cell Adhesion - ADHERE 2 Fourwaves - 2nd International Conference Focused on Cell Adhesion - ADHERE 2

Registration is now open, come join us in beautiful Zadar (Croatia) in September for Adhere2. event.fourwaves.com/adhere2/pages

Our first UK Cell Motility Symposium‬ will be on Friday, June 13th, 2025, 10:00-18:00 in the Sainsbury’s Laboratory, Cambridge. This symposium will be ECR focussed with 12 short talks by PhD student and postdocs. Abstract deadline: May 16th, 2025: register here: forms.office.com/e/DwEGemeNEY

Interphase cell morphology defines the mode, symmetry, and outcome of mitosis During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...

My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...

Tissue mechanics in tumor heterogeneity and aggression Tumorigenesis ensues within a heterogeneous tissue microenvironment that promotes malignant transformation, metastasis and treatment resistance. A major feature of the tumor microenvironment is the heterogeneous population of cancer-associated fibroblasts and myeloid cells that stiffen the extracellular matrix. The heterogeneously stiffened extracellular matrix in turn activates cellular mechanotransduction and creates a hypoxic and metabolically hostile microenvironment. The stiffened extracellular matrix and elevated mechanosignaling also drive tumor aggression by fostering tumor cell growth, survival, and invasion, compromising antitumor immunity, expanding cancer stem cell frequency, and increasing mutational burden, which promote intratumor heterogeneity. Delineating the molecular mechanisms whereby tissue mechanics regulate these phenotypes should help to clarify the basis for tumor heterogeneity and cancer aggression and identify novel therapeutic targets that could improve patient outcome. Here, we discuss the role of the extracellular matrix in driving cancer aggression through its impact on tumor heterogeneity.

Tissue mechanics in tumor heterogeneity and aggression: Trends in Cancer www.cell.com/trends/cance...

Fantastic review covering lots of the stuff we're mulling over in the lab, well worth a read!

Curious about collagen??
There is an amazing program for the Collagen Gordon in New Hampshire this year.
We have ample speaker slots reserved for abstract submissions.

Come and join us!

www.grc.org/collagen-con...
July 6 - 11, 2025

www.grc.org/collagen-grs...
July 5 - 6, 2025

Doug,Rachel,Alex

Cell and Tissue Dynamics (Wickström)

My lab at the Max Planck Institute for Molecular Biomedicine in Muenster, Germany offers postdoc positions in stem cell mechanobiology. www.mpi-muenster.mpg.de/departments/... drop me an email

Cancer cell cycle heterogeneity as a critical determinant of therapeutic resistance

This article provide new insights into the role of cell cycle heterogeneity during #cancer progression, highlighting its significance in identifying novel therapeutic solutions and preventing #CancerRecurrence. #medsky

#OpenAccess: www.sciencedirect.co...

I'm so excited to continue working for @jcellsci.bsky.social
Send us your cool papers 😃

Research Associate - Mechanisms Associated with Extracellular Matrix Assembly and Stability at The University of Manchester Apply for the Research Associate - Mechanisms Associated with Extracellular Matrix Assembly and Stability role on jobs.ac.uk, the top job board for academic positions in higher education. View details...

We are hiring!!

How do basement membranes become stable structures during tissue growth? How can we measure turnover and dynamics?

Come and join our team to help us answer these questions!

@mcrcellmatrix.bsky.social
@stramerlab.bsky.social

More info 👇

www.jobs.ac.uk/job/DLN927/r...