#SmoothMuscleCell #Aging Mechanobiology

24- vs 4-mo rat SkM feed artery

Aged SMC
👉RNAseq ⏬Contractile gene #FocalAdhesion
👉Faster kinetics⏫αSMA filament ⏫vinculin cluster to #CyclicStretch
👉Pressure Inert on 4 kPa matrix; Sensitive on 100 kPa

#FrontPhysiol 2025
www.frontiersin.org/journals/phy...

🤔 #mDia also associates with #microtubules.... (Gundersen team in NatCellBio 2001). @microtubule.bsky.social & I pondered over the #FocalAdhesion splitting & merging phenotype we saw with CLASP-depletion for ages. Great to see someone worked out how to quantitate it!
www.science.org/doi/10.1126/...

EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different c…

Excited to share our most recent study on #integrintraffic #cancer #migration #focaladhesion by @ivaskalab.bsky.social @drpaulinamoreno.bsky.social Niklas Jäntti et al www.sciencedirect.com/science/arti...

Warming up for the upcoming #GRCCellMigration

For me the best video to explain adhesion-dependent #CellMigration by Felix Donghwi Son

More in the website felixvis.artstation.com #sciart #scicomm #ScienceSky #SciSky #cytoskeleton #FocalAdhesion

Congratulations to Minna Roh-Johnson for her @ascbiology.bsky.social #WICB Junior Award for Excellence in Research. A beautiful journey down #focaladhesion memory lane into in-vivo models.

Amazing Angiogenic Disorder Induced by Constitutive Active Src in #EndothelialCell

See the ballooning EC outgrowth from fibrin beads, forming a dome instead of sprouts

Super-intense #FocalAdhesion
Dissembled VE-cad junction
Slow migration

#JCS 2024
journals.biologists.com/jcs/article/...

#YAP #Mechanoptosis #RigiditySensing

pTyr357 YAP, phospho by c-Abl/Src in #FocalAdhesion then translocated to Nuclei, ➡️Apoptosis of MDA-Tpm2.1; MEF on soft matrix 0.25kPa

Cellular sensing of #MatrixStiffness dictates proliferation/apoptosis switch of YAP

#CellRep 2024
www.cell.com/cell-reports...