#Mechanobiology #RigiditySensing

Cellular mechanosignaling for sensing and transducing matrix rigidity

#YAP/TAZ
#Piezo
Mechanometabolism
Substrate with tunable stiffness

Cynthia Reinhart-King lab #CurrOpinCellBiol 2023
www.sciencedirect.com/science/arti...

My continued biological education
#Mechanobiology #RigiditySensing

Stiffness Sensing by Cells

"Substrate Stiffness Can Lead to Heritable Epigenetic Changes"

"Cell Motility Is Faster on Soft Elastic Substrates"

#PhysiolRev 2020
journals.physiology.org/doi/full/10....

#Microtubule #RigiditySensing

Angiotensin II on👤aortic #SmoothMuscleCell➡️
#Piezo1➡️Microtubule destabilization on 72 (not 12) kPa PAGE hydrogel➡️
⏫Cell Volume
⏬by Paclitaxel

Colchicine or HDAC6i⏫ #RigiditySensing on 12 kPa

@jcellsci.bsky.social 2024
journals.biologists.com/jcs/article/...

#YAP #Mechanoptosis #RigiditySensing

pTyr357 YAP, phospho by c-Abl/Src in #FocalAdhesion then translocated to Nuclei, ➡️Apoptosis of MDA-Tpm2.1; MEF on soft matrix 0.25kPa

Cellular sensing of #MatrixStiffness dictates proliferation/apoptosis switch of YAP

#CellRep 2024
www.cell.com/cell-reports...