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Posts by MDC-BIMSB

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PhD in Berlin? The city offers a broad spectrum of doctoral programs w/ funding opportunities & collaborations w/ research institutions. www.doctoral-programs.de/welcome/
@freieuniversitaet.bsky.social, @humboldtuni.bsky.social,
@tuberlin.bsky.social, @unipotsdam.bsky.social,
@udkberlin.bsky.social

6 days ago 10 5 1 0
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❓Ist RNA-Technologie der Schlüssel zu einer neuen Medizin? @landthalerm.bsky.social, Molekularbiologe @humboldtuni.bsky.social @mdc-bimsb.bsky.social @mdc-berlin.bsky.social, erforscht, wie die Genaktivität auf Ebene der mRNA reguliert wird & für neue therapeutische Ansätze genutzt werden kann.(1/2)

1 week ago 1 1 1 0
GSCN Stem Cell Club, Listen to Stefanie Grosswendt from the Max Delbrück Center Berlin Institute for Medical Systems Biology for her input about uncovering ligand–receptor dialogues between individual cells. Rüdiger Behr from the Deutsches Primatenzentrum will speak about non-human primate pluripotent stem cells. 

When: April 16, 2026; talks: 4.15 p.m. - 5.45 p.m., social event: 5.45 p.m. - 9.00 p.m 

Where: In person: Medizinische Biotechnologie – Lecture Hall 13B, Technische Universität Berlin; online: Zoom

GSCN Stem Cell Club, Listen to Stefanie Grosswendt from the Max Delbrück Center Berlin Institute for Medical Systems Biology for her input about uncovering ligand–receptor dialogues between individual cells. Rüdiger Behr from the Deutsches Primatenzentrum will speak about non-human primate pluripotent stem cells. When: April 16, 2026; talks: 4.15 p.m. - 5.45 p.m., social event: 5.45 p.m. - 9.00 p.m Where: In person: Medizinische Biotechnologie – Lecture Hall 13B, Technische Universität Berlin; online: Zoom

🧬 This month’s GSCN Stem Cell Club features two thought-provoking talks by @stefaniegrosswendt.bsky.social from @mdc-bimsb.bsky.social and Rüdiger Behr from @primatenzentrum.bsky.social .

👉 More info and the Zoom link here: www.gscn.org/conferences-...

1 week ago 1 1 0 0
Promotional graphic for a "Berlin Brains on Tour" event. A colorful microscopy image of brain tissue appears in the background. Overlaid text reads “Nanoplastic in the brain,” “Berlin Brains on Tour,” “Zeiss-Großplanetarium,” and “April 17, 2026,” with the Max Delbrück Center logo in the lower right-hand corner.

Promotional graphic for a "Berlin Brains on Tour" event. A colorful microscopy image of brain tissue appears in the background. Overlaid text reads “Nanoplastic in the brain,” “Berlin Brains on Tour,” “Zeiss-Großplanetarium,” and “April 17, 2026,” with the Max Delbrück Center logo in the lower right-hand corner.

Nanoplastic can reach the human brain. What happens then?

Researchers from the Max Delbrück Center will explore this at “Berlin Brains on Tour” on April 17, 2026, at the Zeiss-Großplanetarium in Berlin.

Free admission. Tickets and more information:
👉 www.mdc-berlin.de/news/events/... 👈

1 week ago 0 1 0 0
MicroRNAs are required within a critical time window to define neural patterning during early human brain development MicroRNAs (miRNAs) are key post-transcriptional regulators of cell state transitions, yet their function in early human brain development is largely unknown. Here, we present a longitudinal analysis of miRNA function in developing human forebrain organoids. We show that mRNAs and miRNAs expression mirrors known developmental gene programs and that miRNA biogenesis peaks at neural commitment. To test the function of miRNAs in regulating commitment, we impaired their biogenesis at defined stages. miRNA disruption during pre-neuronal commitment caused severe patterning defects, whereas post-commitment perturbation had minimal impact on forebrain identity. We show that miRNA loss during pre-commitment increased WNT and BMP signaling, thus shifting cell fates towards non-forebrain identity such as midbrain/hindbrain. These effects could be partially rescued by expressing five miRNAs. Our findings uncover a critical time window where miRNAs regulate morphogen signaling in early human neurodevelopment, establishing them as essential temporal determinants of cell fate and brain regional identity. ### Competing Interest Statement The authors have declared no competing interest.

🚨In our new preprint we show that miRNAs act within a precise temporal window to control cell fate decisions in the human forebrain. 🧠
A study of miRNA expression dynamics and functions during early human brain development. @mdc-bimsb.bsky.social ‬
Check it out! www.biorxiv.org/content/10.6...

2 weeks ago 9 4 0 0
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Characterization of intestinal immune responses in generalized human and murine lipodystrophy @jci.org
www.jci.org/articles/vie...

1 month ago 1 1 0 1
portrait of a man.
Text: "Happy 85th birthday, Detlev Ganten!"

portrait of a man. Text: "Happy 85th birthday, Detlev Ganten!"

Our founding director, physician and pharmacologist Detlev Ganten, celebrates his 85th birthday on March 28, 2026.

Without his dedication, the Max Delbrück Center would not exist as we know it today. We thank him and extend our warmest congratulations!

Read more: www.mdc-berlin.de/news/news/ha...

3 weeks ago 3 1 0 0
a woman and a man. Text: "Our first global fellow postdocs"

a woman and a man. Text: "Our first global fellow postdocs"

We welcome our first global fellows: Sakshi Shambhavi and @jmartcan.bsky.social.
Our new Global Fellow Postdoctoral Program brings researchers into multiple labs at once.

👉 Details: www.mdc-berlin.de/news/news/ou...

@leifludwig.bsky.social @simonhaas.bsky.social @helmholtz.de

3 weeks ago 8 5 0 0
scientific image. Text: "Chaos in lymph nodes promotes cancer"

scientific image. Text: "Chaos in lymph nodes promotes cancer"

In aggressive #lymphomas, inflammatory messengers reprogram the ​“conductors” of the immune system, causing lymph node structure to collapse. A team led by @simonhaas.bsky.social describes this process in ​“Nature Cancer” using #singlecell and spatial analyses: www.mdc-berlin.de/news/press/c...

3 weeks ago 0 1 0 0
A close-up of a human brain held in gloved hands in a laboratory setting. The surface of the brain and its blood vessels are visible. © Charité | Maria Streltsova

A close-up of a human brain held in gloved hands in a laboratory setting. The surface of the brain and its blood vessels are visible. © Charité | Maria Streltsova

A gloved hand places a sample slide into a sequencing device illuminated with green light. © Max Delbrück Center | David Ausserhofer

A gloved hand places a sample slide into a sequencing device illuminated with green light. © Max Delbrück Center | David Ausserhofer

A fluorescence microscopy image showing tissue with red and green signals on a dark background, with a scale bar indicating 300 micrometers. © Max Delbrück Center | Georg Braune, Rajewsky Lab

A fluorescence microscopy image showing tissue with red and green signals on a dark background, with a scale bar indicating 300 micrometers. © Max Delbrück Center | Georg Braune, Rajewsky Lab

A person wearing blue gloves holds a multi-well plate containing organoids in liquid culture. © Einstein Stiftung | Pablo Castagnola

A person wearing blue gloves holds a multi-well plate containing organoids in liquid culture. © Einstein Stiftung | Pablo Castagnola

At the Einstein Center for Early Disease Interception, researchers from twelve Berlin institutions will be pooling their expertise to explore new approaches to prevention, long before symptoms appear, and bring them quickly into practice. Today marks its opening.

👉 www.mdc-berlin.de/news/press/l...

4 weeks ago 3 4 0 1
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Mit Beiträgen von @e-charpentier.bsky.social @hdilger.bsky.social @landthalerm.bsky.social @apombo1.bsky.social @jlrohmann.bsky.social @jlrumberger.bsky.social @scheibenbogen.bsky.social @vallierlab.bsky.social und vielen mehr!

4 weeks ago 3 3 1 1
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Gesund, krank, dazwischen? Das neue #ALBERTJournal zeigt, wie fließend diese Grenzen sind, blickt in den Zellkern, diskutiert Tierversuche, KI und Kryo-Elektronenmikroskopie und zeigt, wie Berliner Forschung Gesundheit neu denkt.
Kostenlos bestellen: www.einsteinfoundation.de/albert/beste...

4 weeks ago 5 2 1 0
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Ready when you are @mdc-bimsb.bsky.social

1 month ago 5 1 1 0
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Ahead of #InternationalWomensDay, meet #mdcBerlin researcher and group leader Melissa Birol.

Her lab models how neurodegenerative diseases progress – focusing on intrinsically disordered proteins and their role in brain dysfunction.

🔗 More: www.mdc-berlin.de/about/values... #WomenInSTEM

1 month ago 18 6 0 1
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In dialogue with the audience, the panel featuring @mdc-berlin.bsky.social group leader Daria Bunina, medical student Georg Braune, and Lillevan, hosted by SooJin Anjou and Nikolaus Rajewsky, then explored the role of mystery in both art and science. 🎨🔬
#mdcBerlin
(2/2)

1 month ago 0 0 0 0
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An unforgettable night at SPARK 12: Seeking the Mysterious in Art and Science! 🎶🧬
We were immersed in a mesmerizing performance by SooJin Anjou of Messiaen’s piano preludes combined with original video art (world-premiere) by Lillevan - a collaboration beautifully blending sound and visuals.
(1/2)

1 month ago 0 0 1 0

🟥Zwei Postdocs an Charité & @mdc-bimsb.bsky.social stärken am EC Early Disease Interception die Expertise zu Biomarker-Validierung & kohortenbasierter translationaler Forschung.
🟥 Am EC Youth Mental Health arbeitet ein Charité-Postdoc zur MRI-gestützten Früherkennung psychiatrischer Erkrankungen.

1 month ago 1 1 0 0
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Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs Nature Structural & Molecular Biology - METALoci, a new three-dimensional genome computational tool, reveals a major rewiring of regulatory interactions during sex determination. By combining...

🤩💪 Out now! 3D regulatory hubs in sex determination

With @mamartirenom.bsky.social & Capel labs, led by @imotagom.bsky.social & @jrotwitguez.bsky.social

1️⃣ METALoci – explore #3DGenome 🧬
2️⃣ Non-coding region controlling Fgf9 🧩
3️⃣ Meis genes = new key players 🌟

👉 rdcu.be/e5sm2

1/n Bluetorial 👇

1 month ago 65 29 1 2
Links das ehemalige Gebäude der "Ständigen Vertretung der BRD in der DDR", rechts wohnte Wolf Biermann.

Links das ehemalige Gebäude der "Ständigen Vertretung der BRD in der DDR", rechts wohnte Wolf Biermann.

Geschichte auf dem Weg ins Labor: im weißen Gebäude links war die "Ständige Vertretung der BRD in der DDR", rechts wohnte bis zu seiner Ausweisung Wolf Biermann. Eine "Botschaft" durfte es nicht sein, das hätte die DDR zu sehr aufgewertet: www.spiegel.de/geschichte/s... – heute ist darin ein… (1/2)

1 month ago 37 3 1 0
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Guten Morgen in die Runde! Diese Woche gibt es meinen Wissenschaftsalltag als Molekularbiologie am @mdc-bimsb.bsky.social / @mdc-berlin.bsky.social, allerlei Hintergründe zu unserer Forschung und natürlich (Versuche von) Antworten auf eure Fragen. Falls jemand da reinschauen will: meine … (1/2)

1 month ago 83 16 2 1
Sheet of paper with the quote: “it does not stop being magic just because you know how it works”

Sheet of paper with the quote: “it does not stop being magic just because you know how it works”

Seen yesterday at the door of a PI office at our institute @mdc-bimsb.bsky.social

I agree 💯 - and good to know that even PIs feel the same after many years of research…

2 months ago 3 3 0 0

🎶✨ SPARK #12, Feb 26, 2026
For the 1st time, SPARK will feature visual art: internationally renowned video artist Lillevan presents a world premiere video interpretation of O. Messiaen’s Complete Preludes (1929), performed live by S. Anjou.
Panel discussion: “Seeking the mysterious in art & science”

2 months ago 0 0 0 0
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We’re excited to host Itai Yanai @itaiyanai.bsky.social (NYU Grossman School of Medicine) at MDC-BIMSB.

Talk: How do cells learn? A mechanism for adaptive genome regulation in cancer

📅 Friday, Feb 20, 2026
🕝 2:30 PM
📍 MDC-BIMSB @mdc-berlin.bsky.social

Host: Jan Philipp Junker
Join us!
#mdcBerlin

2 months ago 3 2 0 0
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Text: Immunology & Inflammation Symposium
Berlin
Mar 17, 2026

Group photo Text: Immunology & Inflammation Symposium Berlin Mar 17, 2026

Registration now open for the I&I Berlin Symposium 2026!
Are you part of Berlin’s immunology community or planning to become one?

On March 17, 2026, the symposium bringing together researchers, clinicians, & early-career scientists working on immunology and inflammation.

2 months ago 9 5 0 0
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🧠 How do brain organoids help researchers study the earliest stages of Alzheimer’s disease?

#mdcBerlin's Agnieszka Rybak-Wolf explains what drives her and how advanced brain organoid models help her team explore how the disease may be initiated.

🔗 Full article: www.mdc-berlin.de/news/news/ag...

2 months ago 8 5 0 0

🚨 1/ Preprint Alert!

Sex determination outcome is conserved across vertebrates (i.e. generating 2 compatible sexes) ♀️♂️

But are the cell types and gene programs behind them conserved too? 🧬

Spoiler: not really 👀

Find out in our new preprint ⬇️

www.biorxiv.org/content/10.6...

2 months ago 23 9 1 1
woman, text: "Agnieszka Rybak-Wolf wins Alzheimer’s research grant"

woman, text: "Agnieszka Rybak-Wolf wins Alzheimer’s research grant"

🎉 Congratulations to Agnieszka Rybak-Wolf on winning a €200,000 Alzheimer’s research grant from the Stiftung Alzheimer Initiative!

👉 Detailed insights: www.mdc-berlin.de/news/news/ag...

2 months ago 13 2 0 0
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We mourn the sudden unexpected loss of Peer Bork who helped shape our commitment to innovative life science.

Read the full obituary by Detlev Ganten: www.mdc-berlin.de/news/news/me...

Photo: Jeff Dowling/European Bioinformatics Institute | @ebi.embl.org

2 months ago 10 2 0 0
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3 months ago 25 2 0 0
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#jobalert | Uwe Ohler #jobalert Humboldt-Universität zu Berlin   @mdcberlin Open position/s in explainable AI for genomics! https://lnkd.in/dwcMkN4e couple of things for context: Out of formal reasons, the position’s ...

#jobalert We have open position/s in genomics and explainable/generative AI @mdc-bimsb.bsky.social @humboldtuni.bsky.social

www.hu-berlin.de/universitaet...

More info also on linkedin:

www.linkedin.com/posts/uwe-oh...

please share!

2 months ago 3 2 0 0