Pointed essay about what Americans faced during wars, the great depression, and the civil rights movement.
Now what is needed is to stay engaged, pay attention, and help where you can.
America is worth it.
new publication in #Nature Commun evaluating PPI prediction by #AlphaFold & co for yeast and human compared to exp. screening.
We show AF predictions at stringent cut-off are high quality. But true novelty is sparse and the experiment outperforms pred. nearly 40-fold.
www.nature.com/articles/s41...
Washington Post story on the devastating destruction of US science with particular focus on disenfranchising women and minorities and the use of multiple year funding (MYF) as a means to throttle numbers of grants. The advert above if for MYF language learning software.
This has to be the best advertising link ever.
The Department of Energy canceled 321 grants worth $7.5 billion last October. Every single one was in a state that voted against the President. Not a single project in a red state was touched.
This week, I asked Energy Secretary Wright a simple question: why?
Cover of report "Mission Aborted: how NASA illegally implemented the president's budget request without congressional approval. Minority staff report, prepared by members of the committee on science, space, and technology, us house of representatives, April 2026
This report came out today by minority staff of the House science committee on how three NASA missions were aborted due to NASA illegally following the FY26 president's budget request instead of congressionally approved budget. Very important reading. 🔭🧪 democrats-science.house.gov/staff-report...
WELL NOW, would you look at that?
A massive, 4-YEAR-LONG study of NEARLY 30 MILLION people in France found that individuals who received a COVID-19 mRNA vaccine had a 74% LOWER risk of death from severe COVID-19 compared to unvaccinated individuals and ZERO increased risk of all-cause mortality.
Earth and Moon from DSCOVR NASA's Earth Polychromatic Imaging Camera (EPIC) aboard the Deep Space Climate Observatory (DSCOVR) satellite captured this unique view of the Moon as it moved in front of the sunlit side of Earth last month. This view shows the fully illuminated “dark side” of the moon that is never visible from Earth. Ian Regan processed this version of the image to account for the Moon's motion. NASA / NOAA / Ian Regan
I hadn't seen this before. This is pretty remarkable.
Earth and Moon in one NASA photo.
ht @astrokatie.com
Our latest paper is out! We built a large-scale mutational map of amylin to understand how sequence drives #amyloid formation, a process linked to type 2 #diabetes🩸📈📉. It’s a step towards connecting molecular mechanisms with human genetic variation in a systematic way.
Validation of aggressive LDL lowering to reduce major adverse cardiovascular events, a randomized trial targeting LDL < 55 mg/dl. In participants with atherosclerotic cardiovascular disease (secondary prevention)
[we didn't have the data from a randomized trial before]
www.nejm.org/doi/full/10....
NIH restrictions on foreign research partnerships significantly impacted 1 in 4 U.S. scientists www.statnews.com/2026/03/27/n... via @statnews.com
#HHS #NIH #science #publichealth
OMB has posted the full-year apportionments for NIH.
openomb.org/file/11511545
I believe this means that NIH now has the spending authority to fund grants!
There may be nuances and I will be tracking these as best I can.
Action Item...Action Item...Action Item
Time to comment on the Framework for the NIH-Wide Strategic Plan
grants.nih.gov/grants/guide...
Comments due by May 16, 2026
"I Wrote Research Funding Announcements for NIH for 22 Years. This Year They’ve Published 14. How NIH went from 756 funding announcements to 14 in two years — and what it means for every disease that depends on federal research" elizabethginexi.substack.com/p/i-wrote-re...
1) the constitution grants congress sole spending power
2) congress apportions money to the NIH to spend on science
3) OMB says "nah"
If you missed a flight because of long TSA lines at the airport, then blame Republican Senator Katie Britt for blocking a bill to fund TSA.
Thank you for this work as always Jeremy, as depressing as it is.
The National Cancer Institute, which has funded all cancer advances in the last several decades, has not issued a single grant this year at the command of the Trump administration.
protein phosphate 2A
The Gur lab has published a new article in JACS Au, a journal of the American Chemical Society, that sheds light on how a promising class of cancer-fighting molecules works at the atomic level.
Read more about the research on protein phosphate 2A, an "off-switch" for cancer:
tinyurl.com/JACSPP2A
A line graph showing the number of NIH projects funded in fiscal year 2026 compared to fiscal years 2020-2025. The fiscal year 2026 curve lies below the other curves and appears to be flattening out somewhat.
All projects
The fiscal year 2026 appears to be flattening out a bit in the past week.
2/9
Stand Up for Science rally poster March 7th, 1:00 PM at Allegheny Landing in Pittsburgh.
Very excited to be speaking at the @standupforscience.bsky.social rally in Pittsburgh on Saturday.
I am speaking just prior to Dr. Rachel Levine
1/2
So... A friend was supposed to give a PURELY SCIENTIFIC talk at NIH within the next couple of weeks and it was cancelled because of a "new process" where all speakers/talks have to be CLEARED BY A POLITICAL APPOINTEE.
a headshot of David Botstein
We are deeply saddened to share the news of the passing of David Botstein, a towering figure in modern #genetics and a foundational force behind SGD.
www.yeastgenome.org/blog/in-memo... #yeast #modelOrganism
New paper alert: Paralog interference contributes to the preservation of genetic redundancy www.cell.com/current-biol...
Final version @nature.com of our paper describing unconventional multicellular development in a choanoflagellate inhabiting an extreme environment. A ton of new data since the first @biorxivpreprint.bsky.social preprint (which we've kept updating).
A brief 🧵 (carried over from the old place)
Make Article I great again
A poster for the Stand Up for Science event in Pittsburgh.
Getting ready for a week from tomorrow!
Find an event near you: www.standupforscience.net/march7
1/2
The impact is already hitting science agencies hard. The NIH—the world's largest public biomedical research funder—has had to rely on leftover stopgap funds.
New grant awards have slowed to a trickle — exacerbating the effects of a record-long shutdown in October.
(h/t @jeremymberg.bsky.social)
Thanks to the Nature team for digging into this. Apportionment is one of those inside-baseball issues that I hoped never to need to learn about... But here was are.
This week's cover @thelancet.com
