Happy to share our new work on the nuclease EXO1, published in Nature Communications. We show that EXO1 is overexpressed in cancers. This promotes nascent DNA degradation, even in BRCA-proficient cells, resulting in genomic instability and chemotherapy sensitization. www.nature.com/articles/s41...

FOMO!!

The Sfeir Lab at MSKCC is hiring a Research Assistant!
We are looking for a motivated scientist with at least 2 years of research experience and a two-year commitment. Learn more about our work here www.sfeirlab.com, and message me your CV and cover letter if interested

Get ready for a new #EMGS webinar: "Understanding molecular mechanisms of mutagenesis with implications in human health and disease" presented by the Mutagenic Mechanisms and Assessments SIG!

Read More and Register Now! emgs-us.org/event/MolMec...

This 👇is such a great opportunity for young scientists in the field. I “grew up” on this conference & still hold so many meaningful relationships to this day that I made at these conferences.

Effects of ribonucleotides on telomeric G4 formation, dynamics, and initiation of ribonucleotide excision repair by RNase H2 Abstract. Human telomeres are composed of TTAGGG repeats that can fold into G-quadruplexes (G4s). G4s can form several different conformations, including p

🎉Kicking off 2026 with our first paper from the Freudenthal lab in NAR. Ribonucleotides reshape telomeric G4s and are resistant to RNase H2 repair. Congrats to the authors and huge thanks to our collaborator Hui-Ting Lee! academic.oup.com/nar/article/...

Replication-associated base excision repair/single-strand break repair regulates PARG inhibitor response via the PRMT1/PRMT5/ATR axis Abstract. Poly(ADP-ribose) polymerases 1 and 2 (PARP1/PARP2), and poly(ADP-ribose) glycohydrolase (PARG), modulate the level of poly(ADP-ribose) (PAR), a p

Great to see our latest study out in NAR Cancer: Replication-associated base excision repair/single-strand break repair regulates PARG inhibitor response via the PRMT1/PRMT5/ATR axis url: academic.oup.com/narcancer/ar... @weldeiry.bsky.social @emgsus.bsky.social

Great start to 2026! Another successful collaboration with @professorantony.bsky.social lab & final to piece to Dr. Jessica L. Norris's Chemistry PhD thesis with new additions by current Chemistry PhD graduate student Grace Young. Thanks to NIGMS for funding our groups.
doi.org/10.1093/nar/gkaf1478

What does phosphorylation do to RPA?

This has been a long-standing question in the field of genome integrity.

In our newest publication in Nature Communications rdcu.be/eT4z3 with @proforiganti.bsky.social , we reveal the answer.

Thanks to funding from NIGMS to our groups.

ANTONY LAB SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE Edwin Antony Lab Website

POSTDOCTORAL POSITION IN STRUCTURAL BIOLOGY
We need a structural biologist to work on several CryoEM datasets. For more information, please visit: www.antonylab.org

Expertise in structure refinement and model-building are required.

Please share.

Members of @acsbiol.bsky.social, the Fall 2025 Election is occurring now & will run until 11/28. To ensure you receive your ballot, be sure that your ACS membership is up to date & your email filters are set to receive from elections@vote-now.com.

Had such an exceptional seminar visit to the Dept. of Biochemistry & Molecular Genetics @ the University of Virginia School of Medicine. Beautiful campus & outstanding scientific community. Thank you @tmweaver.bsky.social for the invitation & all staff, students & faculty for the hospitality.

Postdoctoral Scholar (Chemistry Department) APPLICATION INSTRUCTIONS: CURRENT PENN STATE EMPLOYEE (faculty, staff, technical service, or student), please login to Workday to complete the internal application process. Please do not apply here, a...

We ARE…HIRING POSTDOCS!!

The Hedglin Lab at PSU is looking for PhD graduates interested in biophysical & kinetic investigations of human DNA replication pathways. Further details of the position are below. Please spread the word & DM with any questions.

psu.wd1.myworkdayjobs.com/PSU_Academic...

Co-organizing a one day FREE conference on Genome Instability- Discovery to Personalized Medicine 11/1/25. Please join us! Short talks available. https//noncredit.t...

It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it".

During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.

Read our review and find out why and how: doi.org/10.1016/j.ti...

Postdoctoral Training Programs Funded by the National Cancer Institute (T32CA186895), the program at City of Hope provides exceptionally motivated, recent (2 years or less) postdoctoral fellows with scientific knowledge, researc

We have openings for a postdoctoral training program on DNA Damage and Oncogenic Signaling. Our past trainees have been very successful. Apply by Aug 31 for full consideration. See link for details. www.imgs-coh.edu/postdoctoral...

A human high-fidelity DNA polymerase holoenzyme has a wide range of lesion bypass activities Abstract. During replication, lagging strand lesions are initially encountered by high-fidelity DNA polymerase (pol) holoenzymes comprised of pol δ and the

So happy & excited to see this out. An honest & sincere thank you to the editor & reviewers for their constructive criticism & feedback that helped bring the best version of this story to life!
doi.org/10.1093/nar/...

From cooperation to conflicts – a complicated relationship between transcription and replication. A tight coordination between transcription and DNA replication is essential to maintain genome stability. Both excessive transcription and upregulated…

Our new review on how the initiation of DNA replication is coordinated with transcription is now online! Congratulations to @syedshahidmusvi.bsky.social!
www.sciencedirect.com/science/arti...

#3 Chemistry PhD defense from the lab was a success. Congratulations Dr. Rachel Dannenberg, PhD!! We are so very proud of you & excited for your future. Thank you for your unwavering dedication, determination, grit & everlasting footprint on the lab.

Join us NEXT WEEK for the #EMGS webinar "Oxidative DNA Damage and Repair: Impacts and Methods of Detection," featuring a workshop lead by Drs. Laurie Sanders and Tobias Dansen, a keynote talk by Dr. Karlene Cimprich, and more!

Register Today: emgs-us.org/event/OxiDNA...

Research mentors, "unofficial" mentors within the PSU & greater scientific community, colleagues, former lab mates. Thank you all so much.

This is a credit to all past & present lab members whose hard work, dedication, & scientific intrigue made this dream a reality. Also, a credit to SO many along the way (too many to mention by name) that provided unwavering support, motivation, & inspiration.

Penn State announces tenure-line faculty promotions, effective July 1, 2025 | Penn State University The following is a list of academic promotions for tenured and tenure-line faculty members at Penn State, effective July 1, 2025.

It's official: Promoted to Associate Professor of Chemistry with Tenure. Beyond proud & excited for the lab to continue our journey in the genome stability field & charter new territories from within such an amazing community.

Don't miss the next #EMGS webinar "Oxidative DNA Damage and Repair: Impacts and Methods of Detection," presented by the EMGS DNA Repair SIG. 🧬

Register Today: emgs-us.org/event/OxiDNAWEB

Cryo-EM captures the coordination of asymmetric electron transfer through a di-copper site in DPOR Nature Communications - CryoEM snapshots of the nitrogenase-like DPOR protein complex captured during turnover reveal that asymmetric conformational changes, substrate recognition, and an interplay...

Our story detailing how asymmetry in nitrogenase-like proteins regulate electron transfer reactions is finally out! rdcu.be/ejaeK Congratulations to postdoc @rajnandani.bsky.social and fantastic collaborators. Thanks to funding from the Department of Energy and the NIH.

🧬 Don't miss the fourth and final session of NAR Cancer's 5th Anniversary Virtual Symposium!

🕛 Thursday 17 April at 12pm US Eastern time

👥 Speakers include Dr Elise Fouquerel and Dr Robert W. Sobol

Register here: lnkd.in/eRxxSxeu

#NARCancer #PARPInhibitors #DNARepair #GenomicStability

Sorry to hear that. Any luck yet? DM if there is still a problem.

Thanks Josh!!

Another great collaboration with the @professorantony.bsky.social lab.

Excited to share our new pre-print. Direct, ensemble FRET assays developed by our lab reveal that assembly of Rad51 filaments at stalled replication sites via RPA/Rad51 exchange causes complete & irreversible PCNA unloading. Big implications for interplay between human DNA damage tolerance pathways