Galectin-9 regulates #DendriticCell polarity and uropod contraction by modulating RhoA activity, say Guus Franken, Laia Querol Cano and colleagues: rupress.org/jcb/article/...
📕 JCB Immune Cell Biology collection 👉 rupress.org/jcb/collecti...
#AAI2026
Cancer’s cluster bombs The bloodstream is a dangerous environment for a solo cancer cell. Wandering tumor cells often huddle together, thereby boosting their chances of arriving at a promising location to start a new tumor.
Tumor cells often metastasize in clusters with other cells, offering novel targets for treatments.
Learn more: https://scim.ag/4vGFV50
How does an orbiting spherical tissue suddenly break symmetry and sprout invasive strands? We can predict this behavior from the initial morphology!
Hi, I’m @jiwon-kim.bsky.social from @ianywonglab.bsky.social.
Collective #migration requires balancing force and flexibility. @vitoryang.bsky.social, @polarityi3s.bsky.social et al. identify RhoGAP15B as a local brake on RhoA-#myosin contractility in border cells, stabilizing front protrusions and coordinating group movement rupress.org/jcb/article/...
Wolf, K., Wu, Y. I., Liu, Y., Geiger, J., Tam, E., Overall, C., Stack, M. S., & Friedl, P. (2007). Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion. Nature cell biology, 9(8), 893–904. #EpithelialMechanics
buff.ly/cPNltZb
Experienced in nano-and micro-fabrication? MBI is recruiting a new Head of our Microfabrication Core Facility. More details in the flyer and at www.mbi.nus.edu.sg/jobs/seeking...
Can you guess why the microtubules are organized so differently at the bottom and top in this gigantic COS cell? (a game for you @manuelthery.bsky.social)
Congratulations!!! 🥳
I'm so pleased to see this work on neural crest development out in Nature today! This was a truly fantastic collaboration with @gleesonlab.bsky.social, Keng loi (Harry) Vong and @xiaoxuyang.bsky.social. Huge thanks to everyone involved 👏 🧪🐣 #devbio
www.nature.com/articles/s41...
New paper out 💥 3D cell-cell contact reconstitution with synthetic vesicles and (primary) immune cells to study how different proteins and carbohydrates influence the immune synapse dynamics.
advanced.onlinelibrary.wiley.com/doi/10.1002/...
This is why we love #CalciumSignaling
Look how mechanical damage triggers long range Ca2+ waves in this plant !!
By @annalisabellandi.bsky.social, who is now around here ;)
Full www.science.org/doi/10.1126/... @science.org #microscopy #cell #mechanobiology 🧪🔬
We had covered the history of traction force microscopy (TFM) earlier:
bsky.app/profile/epim...
But what about applying TFM into more physiologically relevant systems, such as those in 3D?
I am @barrasa-fano.bsky.social and I'll be your guide through this thread on #3DTractionForceMicroscopy.
Yinyin Zhuang, @xyshi.bsky.social et al. introduce land-ExM, a superresolution approach that simultaneously maps protein and #lipid ultrastructure to reveal 3D interactions of #membrane #organelles and condensates. rupress.org/jcb/article/...
#ExM #Microscopy #StructuralBiology
This developing quail embryo looks like it's thinking fiery thoughts for #FluorescenceFriday 🐣🔥🧪. Imaged by the fantastic @vanderspuy.bsky.social
Force coordination distinguishes epithelial and mesenchymal modes of collective #chemotaxis. New study from Jorge Diaz and Roberto Mayor @mayorlab.bsky.social @ucl.ac.uk: rupress.org/jcb/article/...
#Migration #motility #Development
We have two funded postdoctoral positions available. Topics encompass:
-Next gen light-sheet fluorescence microscopy instrumentation
-Structured illumination microscopy and other approaches to extend the resolution limit.
-Nonlinear microscopy combined with adaptive optics / phase conjugation
Cells navigating microscale curved environments stretch their nuclei, triggering the membrane stretch-sensitive cPLA2 pathway, which in turn rewires cell signaling and morphodynamics to propel the cell forward and avoid steric hindrance pubs.acs.org/doi/10.1021/...
So excited to share the preprint with the bulk of my PhD work in the Beach @myosincity.bsky.social and Oakes @pwoakes.bsky.social Labs at Loyola University Chicago! We investigate the structure, recruitment, and function of septin networks around the nucleus. A thread:
doi.org/10.64898/202...
How can structures at the vertex of 3 cells have effects at the tissue level?
Join me, @laura-rustarazo.bsky.social, to explore how tricellular junctions (TCJs) act as local tension sensors and regulators of global tissue organization. 🧵⤵️ doi.org/10.1126/scie...
Excited to share our new preprint! and the surprising finding that the second integrin-binding site (IBS2) does not bind integrin.
IBS2 can be better explained as talin-talin interactions mediated via a cryptic talin-binding site in R11.
We also show a new role for vinculin as a mechano-chaperone
New paper out: AFM-tip fluctuations inside the actin cortex reveal that effective temperature can remain unchanged while time-irreversibility/entropy production drop (turnover inhibition). #CellMechanics #ActiveMatter #Nonequilibrium
@poldresden.bsky.social @tudresden.bsky.social
Excited to share Alison's @alisonkickuth.bsky.social paper from the lab out in @nature.com this week! We uncovered how a mechanical ratchet mechanism drives cytokinesis in early #zebrafish embryos. Read more in this thread 🧵 and at www.nature.com/articles/s41... 🤩
@poldresden.bsky.social @mpi-cbg.de
Qian, W., Yamaguchi, N., Lis, P., Cammer, M., & Knaut, H. (2024). Pulses of RhoA signaling stimulate actin polymerization and flow in protrusions to drive collective cell migration. Current Biology, 34(2), 245-259 #EpithelialMechanics doi.org/10.1016/j.cu...
Findings in Science demonstrate that successful mitosis may draw on more mechanisms than commonly assumed.
Learn more in this #SciencePerspective: https://scim.ag/4axnAiA
To all lipid-curious cell biologists: check out this comprehensive overview of lipid-based methods by @gerryhammond.bsky.social and colleagues in @jcb.org — a school of Babel fish for #lipidtime:
rupress.org/jcb/article/...
New discoveries are reshaping how scientists understand the molecular connections between the extracellular matrix and lysosomes—and the resulting implications for research and therapeutics for neurodegenerative disorders.
Learn more in this #ScienceSignaling Review: https://scim.ag/3Yi2sFS
Janssen, V., & Huveneers, S. (2024). Cell–cell junctions in focus–imaging junctional architectures and dynamics at high resolution. Journal of Cell Science, #EpithelialMechanicsReview doi.org/10.1242/jcs....
20-plex volumetric super-resolution imaging of cellular ultrastructure. Preprint, led by @seweryn-galecki.bsky.social, dropping soon.
#HappyNewYear !
Let's start 2026 with a @cellcommlab.bsky.social paper
How many branches is OK during #CellMigration?
It depends on the #cell: for ex. immune cells are just fine.
In collab. w. #NirGov @hfspo.bsky.social
Full www.science.org/doi/10.1126/...
@focalplane.bsky.social @science.org 🧪🔬
