Aging and Viral Evolution Impair Immunity Against Dominant Pan‐Coronavirus‐Reactive T Cell Epitope The immunodominant pan-coronavirus epitope iCope spans amino acids 816–830 within the fusion domain of the SARS-CoV-2 spike glycoprotein. This region exhibits a comparatively low mutation rate, espec....

📣 Happy to announce the publication of another fine piece of work of the Andreas Thiel laboratory in the @eurjimmunol.bsky.social, reporting on the impact of aging on cross-reactive anti-SARS-CoV-2 immune responses: onlinelibrary.wiley.com/doi/10.1002/...

• T cell responses identify asymptomatically infected individuals lacking NCAP antibodies

Kudos to our amazing team and collaboration partners that made this work possible.

#berlininstituteofhealth
#charite
#SarsCoV2
#Crossreactivity

• Low mutation rate in epitopes shared between SARS-CoV-2 and endemic coronaviruses
• Hybrid immunity most effectively boosts pan-endemic-coronavirus-specific immunity
• Targeting 30 epitopes provides effective pan-endemic-coronavirus immunity also in the elderly

Hybrid immunity-based induction of durable pan-endemic-coronavirus immunity in the elderly Loyal et al. show that 30 pan-endemic-coronavirus spike-specific and 31 non-spike epitopes with low mutation rates in SARS-CoV-2 generate strong T cell immunity even in the elderly. Hybrid immunity fr...

It feels good to 📢 the first publication announcement on Bluesky - in these times when science is under threat from some unspeakable individuals. Our first paper @cellpress.bsky.social is out:

Speaker line up for #EMBOTissueImmunity to take place in Basel 🇨🇭 26-29 August 2025. Come join @maurogaya.bsky.social and I for some fantastic #immunology along the Rhine! Please share this invitation - we hope you will join us. Registrations will be open soon.

Id love to be added. Thanks for this valuable community work, Rod.

Thats really helpful, thank you. Could you add me as well please?

Look who's here
@pnas.org ✔️
@science.org ✔️
@naturecellbiology.bsky.social ✔️
@natrevgenet.bsky.social ✔️
@naturebiotech.bsky.social ✔️
@naturemicrobiol.bsky.social ✔️
@naturechemistry.bsky.social ✔️
@genesdev.bsky.social ✔️
@cellchembiol.bsky.social ✔️
@genomeresearch.bsky.social ✔️
@jcellbiol.bsky.social ✔️

Starter pack immunologists.

bsky.app/starter-pack...