A rare case of Trichosporon inkin bloodstream infection in an immunocompetent patient: Diagnostic challenges and antigenic cross-reactivity

A rare #Trichosporon inkin bloodstream infection in an #ImmunocompetentPatient highlights antigen #CrossReactivity and misidentification, stressing the need for improved #FungalDiagnostics and cautious test use.

#IDSky #ImmunoSky #MedSky #PublicHealth

Read: doi.org/10.1016/j.dc...

A rare case of Trichosporon inkin bloodstream infection in an immunocompetent patient: Diagnostic challenges and antigenic cross-reactivity

Rare #Trichosporon inkin infection in an #immunocompetent patient shows diagnostic challenges from misidentification and #CrossReactivity, with host conditions altering antigen expression, stressing caution in #FungalAntigen testing.

#OpenAccess: doi.org/10.1016/j.dc...

Good antibodies start with good data.

Our new anti-DCC, anti-Netrin-1, and anti-IGDCC3 (PUNC) #antibodies come with full validation datasets—including demonstrated lack of #crossreactivity.

Take a closer look: buff.ly/LLL78N2

This case report details a rare #Trichosporon inkin #bloodstream infection in an #immunocompetent patient, showing misidentification and antigen #crossreactivity and underscoring diagnostic challenges with #fungal #antigentests.
#IDSky #EpiSky
#OpenAccess: doi.org/10.1016/j.dc...

I am #obsessed with this concept of #TCR #crossreactivity and race against #pathogens in the context of #autoimmunity

A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides The T cell receptor (TCR) orchestrates immune responses by binding to foreign peptides presented at the cell surface in the context of major histocomp…

I have been silent on this issue in hand -well here it is #TCR and #crossreactivity A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides. www.sciencedirect.com/science/arti...

#posting this again if any #postdoc candidates are interested in digging deep into #TCR #Crossreactivity #Tcell functional studies in #autoimmunity and #cancer -please contact me!

T Cell Receptor Cross-reactivity Directed by Antigen-Dependent Tuning of Peptide-MHC Molecular Flexibility T cell-mediated immunity requires T cell receptor (TCR) cross-reactivity, the mechanisms behind which remain incompletely elucidated. The αβ TCR A6 re…

Continuing on #TCR #crossreactivity "how structural diversity can be presented to and accommodated by receptors of the immune system" @nd-bakerlab.bsky.social www.sciencedirect.com/science/arti...

a cartoon of an astronaut with the words we need you written below him ALT: a cartoon of an astronaut with the words we need you written below him

Anticipating #new #funding -our lab is seeking #postdocs with #expertise in #Tcells #TCRs #crossreactivity #molecularbiology #protein #production Please #email #RT -start date flexible, end of #2025 or beginning of #2026

The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function - Nature Immunology Thymocytes and mature T cells are exposed to a broad range of self-peptides of varying reactivity with TCRs. Hogquist and Jameson discuss how differences in self-reactivity and TCR signal strength dic...

continuing on #TCR #crossreactivity -look at this review by Hogquist and Stephen Jameson @CFI_UMN www.nature.com/articles/ni....

What links dust mites, shellfish, and insect food allergies? A study of 634 allergy patients in Tenerife found that 22% were sensitized to edible insects—often without ever consuming them, due to cross-reactivity with house dust mites. Tropomyosin and arginine ...

What links dust mites, shellfish, and insect food allergies? 🦗🌬️🧪 www.news-medical.net/news/2025042... #FoodAllergy #EdibleInsects #DustMites #CrossReactivity #Allergens #Immunology #Tenerife #MolecularDiagnostics #Tropomyosin #Nutrition

Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability | PNAS αβ T cell receptors (TCRs) are genetically restricted to corecognize peptide antigens bound to self-major histocompatibility complex (pMHC) molecul...

continuing on #crossreactivity #TCR "TCRs expressed by naive T cells are required to respond to all foreign antigens despite never having encountered them before and being unable to adapt to them at the protein sequence level" www.pnas.org/doi/10.1073/...

Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligands. | Journal of Experimental Medicine | Rocke...

Continuing on #crossreactivity Structural basis for #Tcell recognition of altered peptide ligands: a single #TCR can productively recognize a large continuum of related ligands. rupress.org/jem/article-...

Cutaneous adverse drug reactions induced by anticonvulsants: Proposal for allergological work-up and contraindications Cutaneous adverse drug reactions induced by anticonvulsants: Proposal for allergological work-up and contraindications

Letter to editor
Cutaneous adverse drug reactions induced by anticonvulsants: Proposal for allergological work-up and contraindications
#Anticonvulsants #Lamotrigine #Carbamazepine #DrugReaction #AllergologicalWorkUp #CrossReactivity
www.em-consulte.com/article/1732...

11/ The anchor antigen Tregs recognize may not be a self-antigen. It could be microbiota-derived, mimicking self — cross-reactive. 🌿🔄 Loss of specific microbiota providing these antigens could lead to antigen-specific autoimmunity.

#Microbiota
#CrossReactivity

• T cell responses identify asymptomatically infected individuals lacking NCAP antibodies

Kudos to our amazing team and collaboration partners that made this work possible.

#berlininstituteofhealth
#charite
#SarsCoV2
#Crossreactivity

Positive and Negative Selection of T Cells | Annual Reviews A functional immune system requires the selection of T lymphocytes expressing receptors that are major histocompatibility complex restricted but tolerant to self-antigens. This selection occurs predom...

#TCR and #crossreactivity -this time some history and review on positive and negative selection -what to exclude, include and how to diversity. Pertinent given the political climate www.annualreviews.org/content/jour...

Clonal deletion and the fate of autoreactive thymocytes that survive negative selection - Nature Immunology The role of costimulation in negative selection is controversial. Singer and colleagues demonstrate that it is critical for clonal deletion and its absence results in the diversion of thymocytes to an...

Continuing on #TCR and #crossreactivity -an amazing paper from Singer "developmental diversion" In between, I am trying to keep my cool! Be kind to all www.nature.com/articles/ni....

The Evolving T Cell Receptor Recognition Code: The Rules Are More Like Guidelines αβ T cell receptor (TCR) recognition of peptide–MHC complexes lies at the core of adaptive immunity, balancing specificity and cross-reactivity to facilitate effective antigen discrimination. Early s...

Continuing with #TCR and #crossreactivity -here is a great review from @nd-bakerlab.bsky.social onlinelibrary.wiley.com/doi/full/10....

Starting the year with a brand #NOA from #NIAID #NIH and funding from Cure All Fund -if anyone would like to join as a #postdoc in our lab, please let me know -#TCR #structure #function and #crossreactivity

No one is naive: the significance of heterologous T-cell immunity - Nature Reviews Immunology Nature Reviews Immunology - No one is naive: the significance of heterologous T-cell immunity

#Tcell and #crossreactivity #No #one is #naive: the significance of #heterologous #Tcell #immunity www.nature.com/articles/nri...

CD8 T cell tolerance results from eviction of immature autoreactive cells from the thymus Thymic eviction explains CD8 T cell tolerance and why autoreactive CD8 T cells appear in the periphery but not the thymus.

#TCR #crossreactivity "Premature #thymic #eviction is the basis for #CD8Tcell tolerance and is the mechanism responsible for the appearance in the periphery of mature CD8 T cells bearing #autoreactive #TCRs that are absent from the thymus" www.science.org/doi/10.1126/...

Structure of an Autoimmune T Cell Receptor Complexed with Class II Peptide-MHC: Insights into MHC Bias and Antigen Specificity T cell receptor crossreactivity with different peptide ligands and biased recognition of MHC are coupled features of antigen recognition that are nece…

continuing on #TCR #Crossreactivity "recognition of structurally distinct agonist peptides is not indicative of #TCR #promiscuity, but rather #highly #specific alternative solutions to TCR engagement" www.sciencedirect.com/science/arti...

T Cell Cross-Reactivity and Conformational Changes during TCR Engagement | Journal of Experimental Medicine | Rockefeller University Press

here in bluesky continuing on #TCR and #Crossreactivity -another great paper by Andrew McMichael -"Extent of T cell cross-reactivity presents a paradox; there is evidence that T cells are broadly cross-reactive, but other data show narrow specificities" rupress.org/jem/article-...

Hidden threats in plant-based diets: Rising allergies to lesser-known legumes Researchers have identified emerging legume allergens like peas, lentils, and lupines, calling for more extensive studies and better diagnostics to manage increasing allergic reactions. The popularity...

Hidden threats in plant-based diets: Rising allergies to lesser-known legumes 🌿📊🚨 www.news-medical.net/news/2024071... #LegumeAllergy #PlantBased #Diet #FoodAllergies #Vegan #HealthResearch #Allergen #Peas #Lentils #Lupines #FoodSafety #CrossReactivity #Health