The 𝗔𝗟𝗙𝗔-𝘁𝗮𝗴 𝗶𝘀 𝗮 𝗿𝗮𝘁𝗶𝗼𝗻𝗮𝗹𝗹𝘆 𝗱𝗲𝘀𝗶𝗴𝗻𝗲𝗱 𝗽𝗿𝗼𝘁𝗲𝗶𝗻 𝘁𝗮𝗴 (rdcu.be/eFy86 ).

anti-ALFA and anti-GFP single-domain antibodies licensed from @nanotag.bsky.social where they're available unmodified and fluorophore-coupled.

#DNAPAINT #MassivePhotonics #RESI #SMLM

Technology - Massive Photonics TECHNOLOGY WHAT IS DNA-PAINT? DNA-PAINT (DNA-Point Accumulation for Imaging in Nanoscale Topography) is a localization based super-resolution microscopy method that uses short, dye-labeled single stra...

🔬 Our RESI kits achieve:
✔️ Single-protein resolution in dense formations like dimers and clusters
✔️ Full field-of-view imaging for robust statistics
✔️ Compatibility with widefield-TIRF and commercial SMLM microscopes

👉Quick RESI Explainer: www.massive-photonics.com/technology/

𝗡𝗲𝗲𝗱 𝘀𝗶𝗻𝗴𝗹𝗲-𝗽𝗿𝗼𝘁𝗲𝗶𝗻 𝗿𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻? Our RESI imaging kits for GFP and ALFA tagged proteins deliver.

𝗥𝗘𝗦𝗜 𝗶𝘀 𝗮 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗯𝗮𝘀𝗲𝗱 𝗺𝗲𝘁𝗵𝗼𝗱 that achieves sub-nanometer spatial-resolution in cells,for precise imaging of individual proteins (rdcu.be/eFy7c).

👉 Explore kits: massive-photonics.com/product-cate...

Beginner's Guide to DNA-PAINT

COMING SOON...

#DNAPAINT

Exchange-PAINT is powerful. 𝗢𝗽𝘁𝗶𝗺𝗶𝘇𝗲 𝗳𝗼𝗿 𝘀𝗽𝗲𝗲𝗱, 𝗿𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻, 𝗼𝗿 𝗺𝘂𝗹𝘁𝗶𝗽𝗹𝗲𝘅𝗶𝗻𝗴 𝗱𝗲𝗽𝘁𝗵, depending on your experiment.

Combine our kits image to multiple targets via Exchange-PAINT!

𝗤𝘂𝗶𝗰𝗸 𝘁𝗶𝗽:
Not sure if your previous imager is fully washed out?
➡️ Turn on the microscope and check for residual blinking before starting the next round.

𝗪𝗮𝗻𝘁 𝗳𝗮𝘀𝘁𝗲𝗿 𝗶𝗺𝗮𝗴𝗶𝗻𝗴?
Use imagers labeled with spectrally distinct dyes (e.g. Cy3B and ATTO 655).
➡️ Instead of washing between rounds, you can simply switch lasers.

𝗛𝗲𝗿𝗲’𝘀 𝗵𝗼𝘄 𝗶𝘁 𝘄𝗼𝗿𝗸𝘀:
1️⃣ Add Imaging Buffer 1 (with Imager 1) → acquire Image 1
2️⃣ Wash out Imager 1 (pipetting or microfluidics)
3️⃣ Add Imaging Buffer 2 (with Imager 2) → acquire Image 2
4️⃣ Repeat for n targets
No complicated microscope setup needed.

𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗺𝗮𝗸𝗲𝘀 𝗺𝘂𝗹𝘁𝗶-𝘁𝗮𝗿𝗴𝗲𝘁 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 𝘀𝗶𝗺𝗽𝗹𝗲𝗿 𝘁𝗵𝗮𝗻 𝘆𝗼𝘂 𝘁𝗵𝗶𝗻𝗸🔬
In #DNAPAINT, target identity is encoded into the DNA sequence, not in the dye.
That means multi-target imaging doesn’t require more optics, just buffer exchange, called Exchange-PAINT. Key advantage: huge multiplexing potential.

We’re recruiting a PhD student! 🎓Join our team as part of the 𝗠𝗮𝗿𝗶𝗲 𝗦𝗸ł𝗼𝗱𝗼𝘄𝘀𝗸𝗮-𝗖𝘂𝗿𝗶𝗲 𝗗𝗼𝗰𝘁𝗼𝗿𝗮𝗹 𝗡𝗲𝘁𝘄𝗼𝗿𝗸 𝗚𝗟𝗬𝗖𝗢𝗖𝗔𝗟𝗬𝗫!

Your project will focus on developing 𝗹𝗲𝗰𝘁𝗶𝗻-𝗯𝗮𝘀𝗲𝗱 𝗹𝗮𝗯𝗲𝗹𝘀 𝘁𝗼 𝘃𝗶𝘀𝘂𝗮𝗹𝗶𝘇𝗲 𝗴𝗹𝘆𝗰𝗮𝗻𝘀 𝘂𝘀𝗶𝗻𝗴 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝘀𝘂𝗽𝗲𝗿-𝗿𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻 𝗺𝗶𝗰𝗿𝗼𝘀𝗰𝗼𝗽𝘆.

➡️ 𝗟𝗲𝗮𝗿𝗻 𝗺𝗼𝗿𝗲 & 𝗔𝗽𝗽𝗹𝘆: www.linkedin.com/jobs/view/43...

Molecular mapping in DNA-PAINT via modified Gaussian Mixture Modeling - Nature Communications Standard algorithms fail to fully exploit the spatial information in DNA-PAINT. Here, the authors present G5M, an algorithm providing molecular maps by accurately inferring biomolecule positions at di...

New paper alert! Authors introduce 𝗚𝟱𝗠, 𝗮 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧-𝗼𝗽𝘁𝗶𝗺𝗶𝘇𝗲𝗱 𝗚𝗮𝘂𝘀𝘀𝗶𝗮𝗻 𝗠𝗶𝘅𝘁𝘂𝗿𝗲 𝗠𝗼𝗱𝗲𝗹𝗶𝗻𝗴 𝗮𝗹𝗴𝗼𝗿𝗶𝘁𝗵𝗺 that accurately determines true molecular position, even at the 𝗥𝗮𝘆𝗹𝗲𝗶𝗴𝗵 𝗹𝗶𝗺𝗶𝘁, and 𝗶𝗺𝗽𝗿𝗼𝘃𝗲𝘀 𝗲𝗳𝗳𝗲𝗰𝘁𝗶𝘃𝗲 𝗿𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻 𝗯𝘆 ~𝟳𝟬%.

Huge congratulations to all authors!

www.nature.com/articles/s41...

📸 𝗕𝘂𝗶𝗹𝘁 𝘁𝗼 𝗹𝗮𝘀𝘁: The image below was acquired from a Stable Cell Slide after 𝟰 𝗺𝗼𝗻𝘁𝗵𝘀 of storage.

Want to visualize different targets? Ask about a custom Cell slide.

Perfect for demos, training, or getting started with #DNAPAINT!

🔬𝗖𝘂𝗿𝗶𝗼𝘂𝘀 𝗮𝗯𝗼𝘂𝘁 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗯𝘂𝘁 𝗱𝗼𝗻’𝘁 𝘄𝗮𝗻𝘁 𝘁𝗼 𝗽𝗿𝗲𝗽 𝗮 𝘀𝗮𝗺𝗽𝗹𝗲? Need a 𝗿𝗲𝗹𝗶𝗮𝗯𝗹𝗲 #𝗦𝗠𝗟𝗠 𝗱𝗲𝗺𝗼 𝘀𝗹𝗶𝗱𝗲 for your next workshop?

Meet our 𝗦𝘁𝗮𝗯𝗹𝗲 𝗖𝗲𝗹𝗹 𝗦𝗹𝗶𝗱𝗲!A ready-to-image sample with 𝗱𝘂𝗮𝗹-𝘁𝗮𝗿𝗴𝗲𝘁 𝗹𝗮𝗯𝗲𝗹𝗶𝗻𝗴 𝗼𝗳 𝗺𝗶𝘁𝗼𝗰𝗵𝗼𝗻𝗱𝗿𝗶𝗮 𝗮𝗻𝗱 𝘃𝗶𝗺𝗲𝗻𝘁𝗶𝗻.Load and image - no prep required.

www.massive-photonics.com/product-cate...

Kits include ready binders, imager strands, and buffers for imaging and sample prep.

Start revealing cellular structures with nanoscale precision today!

Single-domain antibodies licensed from @nanotag.bsky.social where they’re available unmodified and fluorophore-coupled.

🚀 𝗔𝗹𝗿𝗲𝗮𝗱𝘆 𝘄𝗼𝗿𝗸𝗶𝗻𝗴 𝘄𝗶𝘁𝗵 (𝗳𝗹𝘂𝗼𝗿𝗲𝘀𝗰𝗲𝗻𝘁) 𝗽𝗿𝗼𝘁𝗲𝗶𝗻-𝘁𝗮𝗴𝘀? Take your imaging to the nanoscale with our 𝗽𝗹𝘂𝗴-𝗮𝗻𝗱-𝗽𝗹𝗮𝘆 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗸𝗶𝘁𝘀.

🔬 Available for:
· GFP
· Halo
· RFP
· ALFA
· TagFP
· mEOS

𝗘𝘅𝗽𝗹𝗼𝗿𝗲 𝗸𝗶𝘁𝘀: www.massive-photonics.com/product-cate...

#DNAPAINT #SMLM

Dynamic Binder Exchange Improves Protein Labeling Efficiency in DNA‐PAINT up to 15‐Fold Dynamic Binder Exchange (DyBE) leverages transient binder–target interactions to enhance labeling efficiency by up to 15-fold in super-resolution microscopy. DyBE maps nanoscale receptor tyrosine kin...

🚨New publication alert🚨
Authors introduce Dynamic Binder Exchange (DyBE), an approach that improves labeling efficiency in DNA-PAINT up to 15-fold.
onlinelibrary.wiley.com/doi/10.1002/...
Congratulations to all authors!!

DNA-PAINT resolves E-cadherin-independent cross-junctional F-actin organization in Drosophila embryonic tissue Cell junction remodeling is central to epithelial morphogenesis and tissue rheology, and depends on the interplay between adhesion molecules and the actomyosin cortex. E-cadherin constitutes the molec...

🎉 𝗡𝗲𝘄 𝗽𝘂𝗯𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻 𝗮𝗹𝗲𝗿𝘁 🎉
Authors used 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 & 𝗣𝗲𝗽𝘁𝗶𝗱𝗲-𝗣𝗔𝗜𝗡𝗧 to investigate the 𝗻𝗮𝗻𝗼𝘀𝗰𝗮𝗹𝗲 𝗼𝗿𝗴𝗮𝗻𝗶𝘇𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝗘-𝗰𝗮𝗱𝗵𝗲𝗿𝗶𝗻 𝗮𝗻𝗱 𝗙-𝗮𝗰𝘁𝗶𝗻 at adherens junctions in 𝗗𝗿𝗼𝘀𝗼𝗽𝗵𝗶𝗹𝗮 𝗲𝗺𝗯𝗿𝘆𝗼𝗻𝗶𝗰 𝘁𝗶𝘀𝘀𝘂𝗲. Congrats to all authors!

Our anti-GFP kit was used for E-cadherin imaging.

🔗 www.cell.com/biophysj/ful...

The coolest Christmas party ever? 🏎️🎄We think so.
We swapped lab coats for helmets and raced around the track...turns out our need for speed doesn't stop with experiments.

🥇Jürgen, CEO
🥈Lucia, Scientist
🥉Jonas, Scientist

Quantitative STED microscopy with DNA-fluorophore labels Stimulated emission depletion (STED) microscopy enables super-resolution imaging of complex biological samples in 3D, in large volumes, and live. However, molecular quantification with STED has remain...

New preprint alert!
www.biorxiv.org/content/10.6...
Authors developed DNA-fluorophore labels inspired by DNA-PAINT & enhanced with LNA, enabling robust signal amplification for quantitative STED imaging with single-protein resolution. Congrats to all authors!
Our reagents were used for EGFR imaging.

Who knew Christmas could be so pink? 💗🎄
Team outing to Munich's famous Pink Christmas Market = pink lights, fun vibes, and great company.

Morphological and Hyperphosphorylation Transitions of Nanoscale Tau Aggregates in Alzheimer's Disease Super-resolution microscopy identifies nano-sized tau aggregates (nano-aggregates) and reveals distinct transitions in their morphology and phosphorylation profiles across control, Primary Age-Relate...

𝗧𝗮𝘂 𝗻𝗮𝗻𝗼-𝗮𝗴𝗴𝗿𝗲𝗴𝗮𝘁𝗲 𝘁𝗿𝗮𝗻𝘀𝗶𝘁𝗶𝗼𝗻𝘀 𝗶𝗻 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿'𝘀 𝗗𝗶𝘀𝗲𝗮𝘀𝗲 𝗿𝗲𝘃𝗲𝗮𝗹𝗲𝗱 𝗯𝘆 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧

Full study: doi.org/10.1002/advs...

Authors used our anti-mouse and anti-rabbit DNA-PAINT kits for tau visualization in brain tissue sections.

Congratulations to all authors!!

#DNAPAINT #SMLM #MassivePhotonics

𝗨𝘀𝗶𝗻𝗴 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗳𝗼𝗿 𝗥𝗡𝗔 𝗶𝗺𝗮𝗴𝗶𝗻𝗴, 𝘆𝗼𝘂 𝗰𝗮𝗻:
▪️ 𝗦𝘁𝘂𝗱𝘆 𝗥𝗡𝗔 𝗢𝗿𝗴𝗮𝗻𝗶𝘇𝗮𝘁𝗶𝗼𝗻 - reveal nanoscale org. of individual species in dense environ.
▪️𝗘𝘅𝗽𝗹𝗼𝗿𝗲 𝘁𝗵𝗲 𝘁𝗿𝗮𝗻𝘀𝗰𝗿𝗶𝗽𝘁𝗼𝗺𝗲 - study how RNA expression & organization changes
▪️ 𝗜𝗻𝘃𝗲𝘀𝘁𝗶𝗴𝗮𝘁𝗲 𝘃𝗶𝗿uses - map genome organization & biogenesis with molecular precision

𝗪𝗵𝘆 𝘃𝗶𝘀𝘂𝗮𝗹𝗶𝘇𝗲 𝗥𝗡𝗔 𝗼𝗿𝗴𝗮𝗻𝗶𝘇𝗮𝘁𝗶𝗼𝗻 𝗮𝘁 𝘁𝗵𝗲 𝗻𝗮𝗻𝗼𝘀𝗰𝗮𝗹𝗲?
RNA molecules can form complex networks inside cells vital to gene regulation & disease mechanisms (lncRNAs, P-bodies, viruses).Visualizing organization helps reveal how these (mal)function.Traditional RNA profiling is limited by RNA species density.

𝗢𝘂𝗿 𝗥𝗡𝗔 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻𝘀:
▪️𝗖𝘂𝘀𝘁𝗼𝗺 𝗥𝗡𝗔 𝗙𝗜𝗦𝗛 𝗽𝗿𝗼𝗯𝗲𝘀 - for nanoscale imaging of user-defined RNAs
▪️𝗥𝗡𝗔-𝗙𝗜𝗦𝗛 𝗕𝘂𝗳𝗳𝗲𝗿 𝗞𝗶𝘁 - for no guesswork, high-quality sample prep
▪️𝗣𝗿𝗲-𝗱𝗲𝘀𝗶𝗴𝗻𝗲𝗱 𝗥𝗡𝗔-𝗙𝗜𝗦𝗛 𝗽𝗿𝗼𝗯𝗲𝘀 - for perfect positive controls

🔗 𝗨𝗻𝗹𝗼𝗰𝗸 𝗻𝗮𝗻𝗼𝘀𝗰𝗮𝗹𝗲 𝗶𝗻𝘀𝗶𝗴𝗵𝘁𝘀: www.massive-photonics.com/product-cate...

🚀 𝗜𝗻𝘁𝗿𝗼𝗱𝘂𝗰𝗶𝗻𝗴 𝗠𝗔𝗦𝗦𝗜𝗩𝗘-𝗥𝗡𝗔-𝗙𝗜𝗦𝗛 𝗣𝗿𝗼𝗯𝗲𝘀 𝗮𝗻𝗱 𝗕𝘂𝗳𝗳𝗲𝗿 𝗞𝗶𝘁𝘀 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 of RNA targets 𝘂𝘀𝗶𝗻𝗴 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗺𝗶𝗰𝗿𝗼𝘀𝗰𝗼𝗽𝘆.
🔗: www.massive-photonics.com/product-cate...

#SMLM #DNAPAINT #RNAImaging #RNAFISH #Microscopy #MassivePhotonics

Authors 𝗺𝗮𝗽𝗽𝗲𝗱 𝘁𝗵𝗲 𝗻𝗮𝗻𝗼𝘀𝗰𝗮𝗹𝗲 𝟯𝗗 𝗼𝗿𝗴𝗮𝗻𝗶𝘇𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝘁𝗵𝗲 𝗽𝗿𝗲𝘀𝘆𝗻𝗮𝗽𝘁𝗶𝗰 𝗮𝗰𝘁𝗶𝘃𝗲 𝘇𝗼𝗻𝗲 and revealed that the C-terminus of the scaffolding protein bassoon is oriented toward the synaptic cleft, while its N-terminus extends toward synaptic vesicles.

Fantastic work by Florelle Domart, Evelyn Garlick, Isabelle Jansen, Maria Augusta Lima, & Thomas Dresbach!

We’re thrilled to report 𝗮𝘂𝘁𝗵𝗼𝗿𝘀 𝘂𝘀𝗲𝗱 𝗼𝘂𝗿 𝗮𝗻𝘁𝗶-𝗿𝗮𝗯𝗯𝗶𝘁, 𝗮𝗻𝘁𝗶-𝗺𝗼𝘂𝘀𝗲, 𝗮𝗻𝘁𝗶-𝗚𝗙𝗣, 𝗮𝗻𝗱 𝗮𝗻𝘁𝗶-𝗔𝗟𝗙𝗔 𝘁𝗮𝗴 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗸𝗶𝘁𝘀 𝗳𝗼𝗿 𝗶𝗺𝗮𝗴𝗶𝗻𝗴!

3D MINFLUX combined with DNA-PAINT resolves the arrangement of Bassoon at active zones Neurotransmitter release and membrane retrieval at active zones require precise spatial and temporal coordination relying on an intricate molecular machinery. However, the exact nano-structural organi...

New pre-print alert! “𝟯𝗗 𝗠𝗜𝗡𝗙𝗟𝗨𝗫 𝗰𝗼𝗺𝗯𝗶𝗻𝗲𝗱 𝘄𝗶𝘁𝗵 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗿𝗲𝘀𝗼𝗹𝘃𝗲𝘀 𝘁𝗵𝗲 𝗮𝗿𝗿𝗮𝗻𝗴𝗲𝗺𝗲𝗻𝘁 𝗼𝗳 𝗕𝗮𝘀𝘀𝗼𝗼𝗻 𝗮𝘁 𝗮𝗰𝘁𝗶𝘃𝗲 𝘇𝗼𝗻𝗲𝘀” Congrats to all authors!!

www.biorxiv.org/content/10.1...

#MINFLUX #DNAPAINT #MassivePhotonics #Microscopy #Bassoon

Join us & Massive Photonics on 23 Oct 2025 (4–5 PM CET) for a webinar with Prof. Ralf Jungmann, KOL on DNA-PAINT!

Discover how single-molecule #SpatialOmics is reshaping #BioImaging.

🎁 Win a Smart DNA-PAINT Kit!

Register now: us06web.zoom.us/webinar/regi...

#DNAPAINT #Microscopy #SMLM

Don’t forget to come by our booth at #SeeingIsBelieving2025!! We can't wait to chat 🧬 🔬

📍Booth No. 6

#DNAPAINT #SMLM #Superresolution #Microscopy