Meet our new #STEDYCON2 at #FOM2026 in Stockholm. Bring your own samples and see how STEDYCON2 combines confocal, STED, and lifetime imaging in one flexible system.

Don’t miss the opening talk on the latest advances in #MINFLUX and MINSTED by Stefan W. Hell.

See you at booth 28!

#MINFLUX highlight 2025:
www.nature.com/articles/s41...

Reina et. al.

MINFLUX was used to reveal the concurrent diffusion of nicotinic acetylcholine receptors and fluorescent cholesterol using two-color, sub-millisecond single-molecule tracking.

MIRAVA POLYSCOPE is the world’s only all-in-one solution for confocal, MATRIX, STED and MINFLUX microscopy with resolutions from millimeters down to 3 nm.
Learn how MIRAVA can transform your research: abberior.rocks/mirava-polys...

#miravapolyscope #superresolution #minflux #stedmicroscopy

The molecular basis of force selectivity by PIEZO2 - Nature PIEZO2 is intrinsically more rigid than PIEZO1, and disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in each channel.

New #MINFLUX paper investigating protein #structuraldynamics:
@ericmulhall.bsky.social @rose-hill.bsky.social @ardemp.bskyverified.social et al used abberior MINFLUX + #DNAPAINT +electrophysiology to investigate ion channel PIEZO2's mechanosensory selectivity.
link.abberior.rocks/piezo2
@scripps.edu

#MINFLUX highlight 2025:
www.nature.com/articles/s41...
@abhishek-sau.bsky.social @musser-lab.bsky.social @thebioguy.bsky.social
MINFLUX 3D imaging and 3D tracking visualize bidirectional traffic through nuclear pores, achieving a fivefold increase in track length compared to previous techniques.

The impact of #MINFLUX :
Publications using MINFLUX have reached an average #impactfactor of 17.5, reflecting the technique's contribution to high-level scientific discoveries.

Happy to share the final chapter in the story of PaX Dyes, and my time at @stefanhelllabs.bsky.social at @mpi-mr.bsky.social! Now in @cp-chem.bsky.social, we access the red and far-red regions on the spectrum with our caging-group-free strategy for multicolor #SMLM, #STED, and #MINFLUX #microscopy!

🎉 Now also published in @pubs.acs.org #Photonics ⏩ pubs.acs.org/doi/10.1021/... #MINFLUX #microscopy #Bayes

Parameter optimization for MINFLUX microscopy enabled single particle tracking - Communications Biology A Single Particle Tracking parameter optimization pipeline for MINFLUX microscopy.

New Communications Biology article outlines parameter optimisation for #MINFLUX #microscopy to improve single particle tracking accuracy and extend measurable diffusion ranges in membranes. 🔬#Biophysics
📄 https://doi.org/10.1038/s42003-025-09060-1 
👤 EVBC member: Christian Eggeling

✨ Blinking #nanobodies that work for single-molecule localization 🔬
Our new preprint shows that the self-blinking dye JF635b restores robust, buffer-free blinking in #nanobodies, enabling reliable #dSTORM, #MINFLUX, and more, without chemical-switching buffers. Opening new possibilities for #ExM!

Out now: paper in @natcomms.nature.com applying #DNAPAINT 3D #MINFLUX to study activcation and modulation of the mechano-sensitive ion channel #PIEZO1.

www.nature.com/articles/s41...

Happy Fluorescence Friday!

Effortless protein labeling with our labeling kits for #confocal, #STED & #MINFLUX. Works for proteins >4 kDa: IgG, Fab, nanobodies & more.

Workflow: Prep → React → Clean → Stain

Exceptional signal, stability & performance!

#proteinlabeling #fluorescencefriday

👉 Steffen's preprint addressing "Bayesian #MINFLUX localization microscopy" is out @arxiv-soc-ph.bsky.social A rigorous #Bayesian approach should reduce the number of #photons required for 1 nm resolution by a factor of about 4️⃣! 🔗 doi.org/10.48550/arX... @mpi-nat.bsky.social @steschuu.bsky.social

3D MINFLUX combined with DNA-PAINT resolves the arrangement of Bassoon at active zones Neurotransmitter release and membrane retrieval at active zones require precise spatial and temporal coordination relying on an intricate molecular machinery. However, the exact nano-structural organi...

New pre-print alert! “𝟯𝗗 𝗠𝗜𝗡𝗙𝗟𝗨𝗫 𝗰𝗼𝗺𝗯𝗶𝗻𝗲𝗱 𝘄𝗶𝘁𝗵 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗿𝗲𝘀𝗼𝗹𝘃𝗲𝘀 𝘁𝗵𝗲 𝗮𝗿𝗿𝗮𝗻𝗴𝗲𝗺𝗲𝗻𝘁 𝗼𝗳 𝗕𝗮𝘀𝘀𝗼𝗼𝗻 𝗮𝘁 𝗮𝗰𝘁𝗶𝘃𝗲 𝘇𝗼𝗻𝗲𝘀” Congrats to all authors!!

www.biorxiv.org/content/10.1...

#MINFLUX #DNAPAINT #MassivePhotonics #Microscopy #Bassoon

Missed last week's webinar on MINFLUX sample preparation? No problem! Watch the recording and see how you can optimize your workflow to get the best out of your MINFLUX experiment: link.abberior.rocks/sampleprep2

#MINFLUX #SMLM #superresolution #SamplePrep

We’re really happy to read your view on ISM-FLUX—no better person could comment on this technology! Great to see we share the same vision on the key role of #SPADarray detectors for #MINFLUX -like approaches.
@iitalk.bsky.social @erc.europa.eu @ec.europa.eu
#BrightEyes_ERC #SM-SPAD

📢Last call!
Join our webinar on MINFLUX sample preparation TOMORROW at 15:30 CEST.
Register for free: link.abberior.rocks/sampleprep

#MINFLUX #SMLM #superresolution #SamplePrep

Don’t miss the chance to learn about MINFLUX sample preparation!
Register now for our webinar on Wednesday, October 1, 15:30 CEST: link.abberior.rocks/sampleprep
#MINFLUX #SMLM #superresolution #SamplePrep

Curious about MINFLUX but unsure how to handle sample prep? Already using MINFLUX and want better results?

Join our webinar on MINFLUX sample preparation:
link.abberior.rocks/sampleprep

📅 Wed, Oct 1, 15:30 CEST
✅ Easy-to-follow tips
✅ Common mistakes to avoid
✅ Live Q&A

#MINFLUX #SamplePrep

MIRAVA POLYSCOPE installed and ready for true science beyond barriers at Institute of Science and Technology Austria!
Certainly we will soon see many new publications exploring what's going on at life's nanoscale.
Enjoy your new system!

#MINFLUX #STED #superresolution #MIRAVAPOLYSCOPE

In July, the first two MIRAVA POLYSCOPEs were installed in North America: #NorthwesternU and #Yale are now home to our newest micrscopy platform, facilitating imaging across scales from millimeters to 3 nm resolution.
(Video of installation at Northwestern)

#MIRAVAPOLYSCOPE #MINFLUX #STEDmicroscopy

Super-resolution microscopy of mitochondrial mRNAs - Nature Communications Stoldt, Maass, and colleagues present a study where smFISH is combined with STED and MINFLUX microscopy to map mitochondrial mRNA at nanometre resolution, enabling the exploration of the structural fo...

#Mitochondria researchers listen up:
Stoldt et al. established protocols for #superresolution microscopy of mitochondria, combining #smFISH with #STED and #MINFLUX. They investigate spatial relationships between specific mRNAs and proteins and distinct mRNA shapes.
www.nature.com/articles/s41...

#ISMFLUX shows #SPADarray is the future of #MINFLUX, improving localisation robustness and enabling the transformation of a #confocal #microscope into a #MINFLUX system.
www.nature.com/articles/s41...
#photonresolvedmicroscopy #BrightEyes_ERC
@iitalk.bsky.social @erc.europa.eu @ec.europa.eu

Similar to #MINFLUX, our localization uncertainty scales with L/sqrt(N), with L the TCP diameter and N the number of photons. However, while MINFLUX requires the emitter to be within the scanned area, ISM-FLUX has a much larger localization range, making it more robust. 3/6

Our MIRAVA POLYSCOPE is packed with 30 years of experience in developing and applying fluorescence and #superresolution microscopy. abberior.rocks/mirava-polys...
We are delighted to once again provide ground-breaking technology for research.
#minflux #stedmicroscopy #miravapolyscope

Overlapping nuclear import and export paths unveiled by two-colour MINFLUX - Nature High spatiotemporal precision tracking using 3D MINFLUX shows that nuclear import and export occur in overlapping regions of the central pore, providing insight into transport across the nuclear pore ...

#MINFLUX highlight:
Overlapping nuclear import and export paths unveiled by 2-colour MINFLUX
Nature 2025
@abhishek-sau.bsky.social @musser-lab.bsky.social @thebioguy.bsky.social
3D MINFLUX imaging & tracking with sub-ms time resolution and single-digit nm localization.
www.nature.com/articles/s41...

The seminar provides the perfect starting point for researchers that start with #STED, #MINFLUX applications with various staining strategies #blinking #DNApaint 🧫+l🧬🎨 -> 🔬

Looking forward to the demo of the @abberior.rocks #MINFLUX in few weeks in Bordeaux (organised by @iins-bordeaux.bsky.social and hosted by @iecb.bsky.social)

𝗥𝗲𝗮𝗱𝘆 𝗳𝗼𝗿 𝟯-𝘁𝗮𝗿𝗴𝗲𝘁 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗶𝗺𝗮𝗴𝗶𝗻𝗴?
Meet Massive-AB 3-PLEX, a comprehensive kit for 3-target multiplexing.

#DNAPAINT #SMLM #MINFLUX #microscopy #superresolution

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Amazing talks and workshops at #ELMI2025. One of them was S. Musser, showing his recent results using #MINFLUX microsocpy for the nuclear pore trafficking!!..