Diabetes crisis in kids Dr. Brandy Wicklow discusses a major study tackling Type 2 diabetes in First Nations children and improving care in Manitoba.

DREAM researcher Dr. Brandy Wicklow was recently featured on @ctvnewswinnipeg.bsky.social, where she shared insight on the growing type 2 diabetes crisis among youth in Manitoba—especially in First Nations communities. Watch here: www.ctvnews.ca/winnipeg/vid... @chrimanitoba.bsky.social #diabetes

TOMORROW don't miss hearing from Suresh Mishra about his research

GPR146 in #fat tissue drives adipose-liver crosstalk by increasing adipogenesis and lipolysis. Reducing GPR146 protects against hepatic steatosis in mice #obesity @natcomms.nature.com www.nature.com/articles/s41...

Pancreatic-targeted lipid nanoparticles based on organ capsule filtration - Nature Elucidation of fundamental pancreatic-targeted mechanisms enables the development of lipid nanoparticles for the precise delivery of nucleic acid therapeutics to the pancreas, highlighting their promi...

Pancreatic islet targeted lipid nanoparticles based on organ capsule filtration @nature.com www.nature.com/articles/s41...

Messenger RNA delivery to islet β cells using conjugated lipid nanoparticles Enriquez et al. describe a lipid nanoparticle platform for β cell-enriched mRNA delivery. The system delivers functional mRNA to mouse β cells and to human β cells in a xenotransplant model. In a mous...

Messenger RNA delivery to islet β cells using conjugated lipid nanoparticles www.cell.com/cell-reports...

Long-term risk of offspring type 1 and type 2 diabetes following maternal gestational diabetes mellitus: a nationwide birth cohort study with 10-year follow-up - BMC Medicine Background Evidence on the individual risks of type 1 and type 2 diabetes following gestational diabetes mellitus (GDM) exposure, particularly in large Asian populations, remains limited. We examined ...

Korean birth cohort study with follow-up to 14yrs(n=424K): gestational #diabetes increases risk of offspring T2D and #insulin treatment of gestational diabetes increases type1 and type2 diabetes risk in offspring @dream-diabetes.bsky.social @dohadcanada.bsky.social link.springer.com/article/10.1...

This week Suresh Mishra speaking in the @um-pharmacology.bsky.social seminar series about "Discovery of multifaceted #metabolic and #endocrine functions of the #mitochondrial prohibitin-1" FRIDAY April 10 Join us in A207 Chown at NOON CST or via ZOOM:689 7854 4741 PW:782086 @um-radyfhs.bsky.social

β-Cell adaptation to #metabolic stresses requires prolactin receptor signaling @apspublications.bsky.social @dream-diabetes.bsky.social journals.physiology.org/doi/full/10....

#obesity Associated Gestational #diabetes Promotes Cellular Heterogeneity and Dysfunction in Neonatal Offspring Islets @chrisadoucette.bsky.social @dream-diabetes.bsky.social @dohadcanada.bsky.social #DOHaD www.mdpi.com/3706196

From Michel Aliani @DREAM_diabetes A lipidomics approach identifies the #lipid classes modulated in response to fatty liver in #obesity fa/fa rats relative to lean Zucker rats changes in cardiolipin and PE suggesting altered mitochondrial structure www.plefa.com/article/S095...

Pregnancy-associated #metabolic adaptations in circulating monocytes. Important role of fatty acids. n=40 #pregnant women
www.frontiersin.org/journals/imm...

Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease | NEJM Despite guideline recommendations, evidence from randomized trials evaluating the appropriate low-density lipoprotein (LDL) cholesterol target for secondary prevention in patients with atherosclero...

I’m a lipid biochemist by training and for 20 years I have been saying:

The lower the LDL-C the better for you.

www.nejm.org/doi/full/10....

Epigenetically regulated pancreatic GABA-somatostatin signaling underlies gestational diabetes–induced glucose intolerance in offspring TET-controlled GABA-somatostatin signaling in pancreatic islets underlies intrauterine hyperglycemia-induced glucose intolerance in offspring.

Epigenetically regulated pancreatic GABA-somatostatin signaling underlies gestational #diabetes induced glucose intolerance in offspring #DOHaD @dohadcanada.bsky.social @dream-diabetes.bsky.social www.science.org/doi/10.1126/...

Associations between maternal prepregnancy body mass index and maternal and cord blood metabolome AbstractContext. Prepregnancy body mass index (pBMI) is associated with the maternal metabolome during pregnancy. However, evidence remains inconclusive wh

Associations between maternal pre #pregnancy body mass index and maternal and cord blood #metabolome academic.oup.com/jes/article/...

CIHR Project Grant Cycle Restructuring Dear colleagues, Below you will find a draft letter regarding the proposed transition to a single annual CIHR Project Grant competition, and to invite you to sign on if you are in agreement with its c...

With the rumblings around CIHR wanting to move to one cycle per year not going away, in consultation with a diverse stakeholder group, we have put together a letter for CIHR leadership. Please consider signing this letter and share/RT: docs.google.com/forms/d/e/1F... @cannabrain.bsky.social

A brief guide to statistical analysis of grouped data in preclinical research - Nature Metabolism Clustering and nesting (C&N) arise in many preclinical studies, such as when animals are group-housed or share litters, or in cell culture. Ignoring C&N undermines the validity of analyses. Here, we explain how C&N arise, as well as valid designs and analyses.

#Throwback 🧪

COMMENT | A brief guide to statistical analysis of grouped data in preclinical research

@colbyvorland.bsky.social
L Golzarri-Arroyo
DB Allison

Today is #FutureGenerationsDay. @dohadcanada.bsky.social is marking the day alongside LA-DOHaD and @usdohad.bsky.social shared reflection on early life, long-term health, and the decisions that shape generations

Don't miss Ben Lindsey speaking today in the @um-pharmacology.bsky.social seminar series @um-radyfhs.bsky.social Join us in A207 Chown or via ZOOM at NOON CST

Interesting mechanistic study: Branched chain keto acids inhibit glucose stimulated #insulin secretion by redirecting glucose metabolism to the lactate dehydrogenase-lactate axis @dream-diabetes.bsky.social @chrisadoucette.bsky.social @natcomms.nature.com rdcu.be/e8RK5

Incretin hormones GLP-1 and GIP connect #metabolism and cardiovascular #health. Our new REVIEW highlights the latest about how endogenous incretins shape cardiometabolic disease @dream-diabetes.bsky.social @um-pharmacology.bsky.social @um-radyfhs.bsky.social cdnsciencepub.com/doi/10.1139/...

Gestational Weight Gain and Pregnancy Outcomes After GLP-1 Receptor Agonist Discontinuation This cohort study examines gestational weight gain and pregnancy outcomes after glucagon-like peptide-1 (GLP-1) receptor agonist discontinuation.

Gestational Weight Gain and #Pregnancy Outcomes After GLP-1 Receptor Agonist Discontinuation @jamanetworkopen.com study of 10-year n=448 exposed singleton pregnancies jamanetwork.com/journals/jam...

REVIEW by @ozannelab.bsky.social Incretin receptor agonism during #pregnancy: implications for mother and baby @dohadcanada.bsky.social portlandpress.com/clinsci/arti...

This week welcoming Ben Lindsey to the @um-pharmacology.bsky.social seminar series to speak about using Zebrafish to "Uncover neural stem cell capacity in health and repair" A207 Chown at NOON CST or via ZOOM:689 7854 4741 PW:782086 @um-radyfhs.bsky.social www.lindseylab.ca

TODAY! @um-radyfhs.bsky.social @umbmg.bsky.social @chrimanitoba.bsky.social @um-pharmacology.bsky.social

Check out this great feature of DREAM investigator Dr. Lucy Marzban and her incredible research on amyloid formation in diabetes 👏🔬 @chrimanitoba.bsky.social @uofmpharmacy.bsky.social #diabetes #research #islets

Excited to have @meaghanjones.bsky.social speak in the
@um-pharmacology.bsky.social seminar series about "Epigenetic mechanisms linking early life exposures to long term health outcomes" @chrimanitoba.bsky.social @dohadcanada.bsky.social Join us A207Chown NOON CST or ZOOM:689 7854 4741 PW:782086

Uncovering the cause of gestational diabetes Rady researchers studying frequent pregnancy complication

New research at @chrimanitoba.bsky.social is shedding light on what may trigger gestational diabetes. @verndolinsky.bsky.social found that low levels of the protein SIRT3 may disrupt insulin-producing cells, offering new clues for prevention and treatment during pregnancy. umtoday.ca/stories/unco...

a poster that says more women in stem more role models for girls more girls choose studies in science tech engineering math ALT: a poster that says more women in stem more role models for girls more girls choose studies in science tech engineering math

So many abstracts being written for research days and conferences in the lab! 😅

It’s awesome to see the hard work 💪🏻💪🏽 and progress of our team,

and the diverse work we do in translational women’s and perinatal health science!!

Happy #InternationalWomensDay
#IWD2026

International Women's Day 2026 Nature highlights developments in women’s health research and career guidance for women in science.

International Women’s Day celebrates the Earth’s 4 billion female inhabitants. Nature brings you a collection of the latest on advancements in women’s health and career guidance, advice and inspiration for women in science. 🧪 #IWD2026

Infographic highlighting the contributions of twelve women in chemistry history. Full alt-text available at the link in the post.

On #InternationalWomensDay, here's another edition of Women in Chemistry History. This edition features women whose achievements in chemistry include the creation of synthetic emeralds, the impact of diet on intelligence and health, and more: www.compoundchem.com/2026/03/08/i...

#ChemSky 🧪