My lab has been studying human genes that control infection HIV infection of CD4+ T cells for over a decade. Today we report a major milestone in Cell: www.cell.com/cell/fulltex...

A herculean effort by many, but esp. the first three authors: Ujjwal Rathore, Eli Dugan, and Hunter Thornton working in the Krogan and Marson labs, with a veritable army of collaborators from HARC (harc.ucsf.edu) and beyond.

Press release: gladstone.org/news/scienti... (inc. paper link)

ABCC1 protects skin dendritic cells from FITC-induced toxicity by efflux and extracellular glutathione buffering www.biorxiv.org/content/10.64898/2026.01...

FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry
www.cell.com/immunity/ful...
@cp-immunity.bsky.social @gladstoneinst.bsky.social

Insights @jem.org: Bosteels, Stainier, and @reisesousalab.bsky.social highlight work by Tam et al. (rupress.org/jem/article/...) revealing that GPR34, a lysophosphatidylserine receptor, promotes apoptotic cell uptake and cross-presentation by type 1 #DendriticCells. rupress.org/jem/article/...

Tam, Cyster et al. identify GPR34 as a splenic cDC1 receptor that is required for efferocytosis and for the cross-presentation of apoptotic cell–associated antigen to CD8 T cells. rupress.org/jem/article/...

#InnateImmunity #inflammation
@hhmi.org

Brain fibroblasts are dynamic regulators of tissue repair and immunomodulation after injury, with implications for understanding scar formation, function and long-term outcomes of acute brain injuries @natimmunol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Niche-specific dermal macrophage loss promotes skin capillary ageing - Nature Capillary-associated macrophages are selectively lost over time, contributing to impaired vascular repair and reduced tissue perfusion in older mice.

When Macrophages Disappear, Skin Blood Vessels Age!
Check out our new study @nature.com that uncovers how the loss of capillary-associated macrophages with age blocks vessel repair and blood flow, revealing a new cellular trigger of tissue aging. #Aging #Immunology
👇👇
www.nature.com/articles/s41...

Dynamic fibroblast–immune interactions shape recovery after brain injury - Nature Spatial transcriptomic studies and lineage tracing reveal that, after brain injury, transient profibrotic fibroblasts develop from existing brain fibroblasts, infiltrate lesions, regulate the local im...

1/ Thrilled to share that my PhD thesis work is now out in its final form @nature.com! A huge thanks to the entire team (which has only grown since we first put this out), our peer reviewers, the Nature editorial team, and the incredible @arimolofskylab.bsky.social.

www.nature.com/articles/s41...

Congrats to the amazing Dr Arce!

Review @sciimmunology.bsky.social @arimolofskylab.bsky.social @annamolofskylab.bsky.social @nickmroz.bsky.social @phagocyticpai.bsky.social
The nervous and type 2 immune systems regulate each other via cytokines and neurotransmitters
www.science.org/doi/10.1126/...

Immunoglobulin A controls intestinal virus colonization to preserve immune homeostasis Germinal center-derived, T cell-dependent secretory IgA prevents chronic intestinal colonization by select enteroviruses. In its absence, antigen-driven CD8αβ⁺ intraepithelial lymphocytes partially co...

#WeekendRead! #ImmunoglobulinPower! Jabri &co show @cp-cellhostmicrobe.bsky.social that intestinal IgAs prevent chronic colonization of distinct enteric viruses, which are otherwise controlled by intraepithelial lymphocytes that, though, do not block colitis exacerbation due to altered virome.