Resource @cellcellpress.bsky.social @wehi-research.bsky.social @mediocre-jake.bsky.social
The E3-ome gene-centric compendium reveals the human E3 ligase landscape
www.cell.com/cell/fulltex...

The E3-ome gene-centric compendium reveals the human E3 ligase landscape The E3-ome defines the human repertoire of ubiquitin E3 ligases, creating a unified resource that maps their diversity across the ubiquitin and ubiquitin-like systems. By consolidating fragmented knowledge, this framework provides a foundation for studying ubiquitin signaling and accelerating discovery.

Now online! The E3-ome gene-centric compendium reveals the human E3 ligase landscape

STING signalling as a mediator between lipid metabolism and innate immunity Nature Reviews Molecular Cell Biology, Published online: 30 March 2026; doi:10.1038/s41580-026-00967-zThis Comment discusses the bidirectional interplay between STING signalling and lipid homeostasis, highlighting the emerging therapeutic relevance of this regulatory network.

New Online! STING signalling as a mediator between lipid metabolism and innate immunity

Vila, Messaoud-Nacer, Taffoni, @nadinelaguette.bsky.social et al show that DNA-PKcs, a major DNA damage response actor, interacts w/ cyclic dinucleotides through its kinase domain, ensuring CDN-associated signal termination, while CDNs inhibit DNA-PKcs catalytic activity rupress.org/jem/article/...

Ubiquitin ligase CHFR impairs Tie2 signaling via K48-linked ubiquitylation and degradation of Akt1 in endothelial cells www.biorxiv.org/content/10.64898/2026.03...

The E3-ome gene-centric compendium reveals the human E3 ligase landscape To define and systematically characterize the human E3 ubiquitin ligase (E3) landscape, we generated the E3-ome, a compendium of E3s encoded by the hu…

So delighted to have been part of this fantastic collaboration spearheaded by Ngee Kiat 'Jake' Chua (蔡毅杰) and Rebecca Feltham! Congratulations on bringing together so many experts in the field to make such an important resource 🎉 it has been a pleasure!

www.sciencedirect.com/science/arti...

Amazing to be able to work with the team in Otago

Many fundamental discoveries on what we know about RING E3s were made by Peter Mace at Catherine Day in New Zealand

Always a pleasure to go back to basics and apply it with a modern lens

@otagobiochemist.bsky.social

Out on the 2nd April 2026 issue of Cell

Should really build a Bluesky thread around the E3-ome development

Thanks for sharing!

It wasn't a straightforward path so many more cool E3s to be uncovered!

Congratulations Jake @mediocre-jake.bsky.social, Bekky Feltham and team on their phenomenal effort in putting together the E3-ome, published in Cell www.cell.com/cell/fulltex....

An extremely valuable resource for ubiquitin researchers.

A breakthrough in lipid imaging: spatial lipid distributions in organelles! Fantastic work from @nadlerlab.bsky.social 🤯

Glückwunsch, Bruderherz! Really outstanding work by @bartellab.bsky.social and Schulman Lab. This is how transatlantic research is done 🇺🇸🇩🇪.

Cofilin-1 is a redox-sensitive guard of the NLRP3 inflammasome @natimmunol.nature.com
www.nature.com/articles/s41...

Ever wonder how IDRs and folded domains work together to control function? Using ubiquilins, multidomain proteins involved in protein degradation, we show in our new preprint that IDRs aren’t just linkers, but regulate ensemble and function. Read it here: doi.org/10.64898/202...

UK Proteostasis Meeting 2026 – Reminder: Register Today


📅 20–21 July 2026 at The Francis Crick Institute, London

🗓 Abstract deadline: 1 May 2026


💷 Fees: £45 (Student/Postdoc) | £75 (Group Leader)

🔗 Register: forms.gle/dWz2qztKgftB...

🔗 Payment: www.eventbrite.co.uk/e/uk-proteos...

In this Perspective, North, @doroteaartscience.bsky.social, Shoemaker et al. highlight the rapidly expanding role of LC3-interacting regions in autophagy. rupress.org/jcb/article/...

📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti...
#GRC

Scientists: How long have you waited for journal editors to decide whether the journal sends your manuscript out for review?

I’m at 2+ months with a “prestigious” journal — not easy when working in a competitive field.

What’s the longest you’ve experienced?
#AcademicPublishing #PeerReview

Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis - Nature Structural & Molecular Biology Here, Deol et al. use genetic screens in gene-edited reporter cell lines to identify regulators of ferroptosis suppressor protein 1 (FSP1) expression and stability. They show that vitamin B2 metabolis...

1/3 Thrilled to see our paper led by Kirandeep Deol is out in Nature Structural & Molecular Biology! CRISPR screens to uncover a role for vitamin B2 metabolism in stabilizing FSP1 via FAD, revealing a new way vitamins regulate ferroptosis.
www.nature.com/articles/s41...

Lipids Meet Immunity: Metabolic Control of cGAS-STING

Having worked in lipid metabolism and cGAS-STING, I have an appreciation for the regulation of cGAS-STING by lipids, which I co-wrote.

www.mdpi.com/2813-7086/3/...

@wehi-research.bsky.social @sahmri.bsky.social

Lipids Meet Immunity: Metabolic Control of cGAS-STING

This @mdpiopenaccess.bsky.social review we wrote was definitely quite fun as we discuss emerging findings on how 8 classes of lipids regulate cGAS-STING based on notable research over the last 5 years

www.mdpi.com/2813-7086/3/...

Regulation of STING activation by phosphoinositide and cholesterol - Nature Phosphatidylinositol phosphates together with cholesterol bind at the interface between STING dimers, directly promoting high-order oligomerization.

As our review was being written, the timely and amazing back-to-back recent @nature.com papers discussing cholesterol and PI(3,5)P2 regulating STING also came out so we just had to cite it while we were doing the revision!

www.nature.com/articles/s41...
www.nature.com/articles/s41...

STING trafficking as a new dimension of immune signaling STING signaling is at the center of multiple autoinflammatory and neurodegenerative diseases. The authors review how STING trafficking influences signaling

The spatial regulation of STING has gained interest in recent years as discussed here by Nan Yan

rupress.org/jem/article/...

and if you think about it as STING moves in a cell, it encounters the all kinds of lipids as it moves from ER to Golgi to endosomes #science

Lipids Meet Immunity: Metabolic Control of cGAS-STING

Having worked in lipid metabolism and cGAS-STING, I have an appreciation for the regulation of cGAS-STING by lipids, which I co-wrote.

www.mdpi.com/2813-7086/3/...

@wehi-research.bsky.social @sahmri.bsky.social

STING trafficking as a new dimension of immune signaling STING signaling is at the center of multiple autoinflammatory and neurodegenerative diseases. The authors review how STING trafficking influences signaling

The spatial regulation of STING has gained interest in recent years as discussed here by Nan Yan rupress.org/jem/article/...

and if you think about it as STING moves in a cell, it encounters the all kinds of lipids as it moves from ER to Golgi to endosomes

#science

This is a video summarizing our recent paper (www.nature.com/articles/s41...)

youtu.be/eNY2CRlYTRo

New VCP/p97 review article. Report on the excellent VCP meeting at CalTech last year and great overview on VCP and VCP disease.
doi.org/10.1016/j.nb...

Thrilled to be hosting Brenda Schulman, @aakritijain.bsky.social, @crismayorruiz.bsky.social @davidbalchin.bsky.social, @hemmo-lab.bsky.social, Ian Ganley, @kirsteinlab.bsky.social, Juliette Fedry, @elliottlab.bsky.social & @plantophagy.bsky.social - BIG THANKS for accepting the invitation 🙏

The accessory adapters FAF1, FAF2, and UBXN7 accelerate proteasomal degradation by increasing prior p97-mediated substrate unfolding A group of accessory adapters positions the p97 adapter Ufd1 to boost substrate unfolding and subsequent proteasomal degradation.

VCP/p97’s accessory adapters (FAF1, FAF2, UBXN7) boost unfolding and subsequent proteasomal degradation. #ubiquitin. Our paper is out now:
Science Advances www.science.org/doi/10.1126/...

I am incredibly excited to share that I will start my independent lab at the @unidue-zmb.bsky.social at the @unidue.bsky.social as Junior Professor of Cellular Biochemistry. Research in my lab has the goal to decipher the ubiquitin code!
There are multiple open positions!
(1/3)

Allosteric PROTACs: Expanding the Horizon of Targeted Protein Degradation Proteolysis-targeting chimeras (PROTACs) have transformed the concept of chemical intervention in biological systems by co-opting the ubiquitin–proteasome system to selectively degrade proteins. A key...

Allosteric PROTACs: Expanding the Horizon of Targeted Protein Degradation | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/...

The date on the poster says February 5…should be March 5, right?