Cellular RNA interacts with MAVS to promote antiviral signaling Antiviral signaling downstream of RIG-I–like receptors (RLRs) proceeds through a multi-protein complex organized around the adaptor protein mitochondrial antiviral signaling protein (MAVS). Protein co...

Nandan’s @nandangokhale.bsky.social work from our lab highlights the importance of cellular RNA in enhancing MAVS signalosome function, crucial for antiviral signaling initiated by RLRs.

buff.ly/4grnf18

This work is summarized by Sonja Best and Adam Hage.

buff.ly/4fxVMcx

#Science #immunology

I would like to join! Great group!

RNA splicing junction landscape reveals abundant tumor-specific transcripts in human cancer Li et al. thoroughly analyzed RNA splicing junctions in 34,775 samples and identified 29,051 tumor-specific transcripts that may serve as cancer driver genes, neoantigens, and circulating biomarkers.

Very interesting paper!

www.cell.com/cell-reports...

Cancer-associated fibroblast subtypes modulate the tumor-immune microenvironment and are associated with skin cancer malignancy - Nature Communications Fibroblast heterogeneity in the tumor microenvironment can explain their multifaceted role in cancer. Here by single-cell transcriptomic analysis of basal cell carcinoma, squamous cell carcinoma and m...

Cancer-associated fibroblast subtypes modulate the tumor-immune microenvironment and are associated with skin cancer malignancy – Lichtenberger & Kasper labs
www.nature.com/articles/s41...

Thank you very much! It’s really a great environment!

Metabolic targeting of cancer associated fibroblasts overcomes T-cell exclusion and chemoresistance in soft-tissue sarcomas - Nature Communications Cancer associated fibroblasts can shape the tumor microenvironment (TME) and modulate immune infiltration. Here the authors characterize the TME in preclinical models of softtissue sarcomas, identifyi...

Hi all! I recently moved my lab to the MD Anderson cancer center and I’m looking for a motivated postdoc to take over projects on TME and CAFs. See our latest publication below as a reference.
Please spread the message and get in touch if interested in!

www.nature.com/articles/s41...

💡 Inspired by others, as we grow our #AcademicSky #MedSky#ImmunoSky community here @bsky.app 🦋, thought it might be cool to have a #StarterPack for #CancerImmunology.

Please join in or recommend a colleague!

Hope this is useful 👇
go.bsky.app/PRdmHCP

Spatially exploring RNA biology in archival formalin-fixed paraffin-embedded tissues Patho-DBiT enables spatial profiling of a range of RNA species (i.e., mRNA, microRNA, tRNA, splicing isoform, etc.) all at once in clinical formalin-fixed paraffin-embedded tissue with high sensitivit...

www.cell.com/cell/fulltex...

go.bsky.app/7xTwrrn

Starting a list of oncology related peopl. Please tell me more to add. Or any similar listd go.bsky.app/GKXp9Fy @n8pennell.bsky.social

Rhythmic IL-17 production by γδ T cells maintains adipose de novo lipogenesis - Nature Innate IL-17-producing T cells—in particular, adipose γδ17 T cells—are enriched in molecular-clock genes, and the circadian expression of IL-17A and RORγt by these cells has a role in maintaining loca...

www.nature.com/articles/s41...

In vivo dendritic cell reprogramming for cancer immunotherapy Immunotherapy can lead to long-term survival for some cancer patients, yet generalized success has been hampered by insufficient antigen presentation and exclusion of immunogenic cells from the tumor ...

www.science.org/doi/10.1126/...

I would like to joint the group! Thank you so much for making this!

I would like to join the group! Thanks!

Could you add me to the group? Thank you very much!

Can I join the group? Thanks for making this!

Can I join the team? Thanks for making this!

Can I join the team? Thanks for making this!

go.bsky.app/PRdmHCP