🚨Haven't registered for #FGF26? Now's the time!
⌛9 days to go until registration deadline closes.
‼️We still have a few remaining grants available!
Secure your spot today, click here to register ➡️https://bit.ly/4qINe8v
#FusionCellBio
New lab preprint! We know that FGF signaling drives ER+ breast cancer after treatment. Here, we asked how. ETV4, induced by Fgf1, does a lot in vitro but is only necessary (not sufficient) in vivo. Could it reflect high Fgf1 and indicate pending ER+ tumor therapy resistance in obesity?
I'm looking forward to this meeting, connecting with new colleagues, and learning more about FGF signaling! We'll be sharing work on Fgf1 and breast cancer progression. The destination couldn't be better 😉 @fusionconf.bsky.social
The Ets transcription factor ETV4 regulates FGF1-dependent proliferation and glycolysis in ER-positive breast cancer www.biorxiv.org/content/10.64898/2026.01...
Our new preprint is out! We previously reported fewer subcutaneous adipocyte progenitors in obese female mice after sustained tamoxifen treatment. Here we show that tamoxifen suppresses Wnt family member Wisp2/Ccn5 to block estrogen's protection of these cells. Happy Holidays 😊
This year's holiday gifts to the lab...mugs with their favorite (or not?!) proteins for each of their projects 😊
Cell populations in human breast cancers are molecularly and biologically distinct with age
"how age affects cells in the breast tumor microenvironment or how they contribute to age-related pathology."
www.nature.com/articles/s43...
Elizabeth Wellberg @lwellberg.bsky.social & colleagues present a Review in the JCI series on Clinical innovation and Scientific Progress in GLP-1 Medicine:
GLP1 receptor agonists & cancer: current clinical evidence & translational opportunities for preclinical research: www.jci.org/articles/vie...
Many clinical studies have shown reduced cancer risk in people with diabetes of obesity taking GLP-1 family of drugs. A new JCI piece makes the case these drugs should be studied to reduce cancer in people without metabolic disease jci.org/articles/vie...
Will GLP-1 medicines modify the rates and/or outcomes of one or more #cancers A review on the biology, limitations of the data and the road ahead from @lwellberg.bsky.social and colleagues in JCI www.jci.org/articles/vie...
💰ECR grants for #FGF26 now available to help defray the meeting costs for those in junior faculty.
Details on how to apply - click here ➡️https://bit.ly/47ivjOf
⌛️Don't forget talk submission closes soon, submit your abstract now and join us in sunny Malta next May. 🌞
#FusionCellBio
📢🗓️SAVE THE DATE
We are very excited to announce that registration for #FGF26 is now open!!
Join our fantastic chairs and their incredible speaker line up in sunny Malta next May 🌞
🗓️ 07-10 May 26
📍 St Julian's, Malta
✍️ Sign up for updates: bit.ly/3IXaYFB
⌛️ Next deadline: 05 Nov 25
#FusionDevBio
Does anyone want to collaborate on a #breastcancer #obesity #immune project who has a PhenoCycler or can analyze more than 7 protein markers per slide at once? I ran into a road block. #Science
Thank you for submitting your Letter of Intent (LOI) to CZI. We appreciate your interest in our work. CZI has decided not to continue with the second round of its Science Diversity Leadership Awards. We are committed to supporting groundbreaking research that advances the frontiers of scientific knowledge in pursuit of our mission to cure, prevent, or manage all diseases by the end of the century. We will provide information on future funding opportunities. We look forward to staying in touch. Bil Clemons, Program Officer, CZI
Pretty sad. Just got the email that CZI is canceling the second round of Diversity Leadership Awards. Private industry will definitely not fill the hole that NIH and NSF are leaving. 😢💔
A few days ago my neighbor said she was furious but wasn't sure yet what to do. I told her there have to be lines or waves of resistance and when the group ahead of her needed a break, she can take over and will have learned more by then. A relay is the perfect analogy.
I'm in a red state (I'm not a republican) and it is terrifying here now. We feel helpless but some are speaking out as best we can. I wake up crying at night worried about my family's future but also about our country. It's gutting to see these men destroy our global relationships, all for power 😔
Despite the current uncertainty of being a scientist, I am excited to share our manuscript demonstrating an interesting mechanism of how swirling motion of breast cancer cells align collagen fibers radially at the tumor-stroma interface to enable their invasion (1/11) @thechaudhurilab.bsky.social
Centering myself in the kitchen today. I'll give sauerkraut another shot after something went very wrong last time. Science at home!
🔔🧪 Super interesting paper from the Sanz-Moreno group showing that the #ECMatrix influences #tumour #dissemination, with distinct #structure in different tumour regions that then affect #invasion patterns.
#cancer #metastasis #mechanosensing
#mechanoregulation
www.nature.com/articles/s41...
Thanks friend 🩷
Science question... does anyone know what fraction (in general) of cholesterol is converted to steroid hormones in humans, vs other downstream cholesterol products? My husband says it's negligible... 😐 Does cholesterol go up after menopause in women?
Are you a senior PhD student or postdoc? Do you have a cool science story to tell? Do you want to visit Buffalo when the weather is perfect? Then apply for the Emerging Leaders Seminar Series at Roswell Park! DM or email me with questions. (RT please!)
www.roswellpark.org/education/pr...
I made a starter pack for mammary developmental and cancer biologists.
Tell me if you want to be added or suggest colleagues.
go.bsky.app/8ZbyV6c
Very proud of our 2 summer researchers, who worked in the lab between 1st and 2nd yr of med school. Great job at the symposium today, Michaela and Tom, and thank you for your hard work! Also thanks to Nisha and Jumana for volunteering to judge presentations 😎 #ProudPI
An estrogen receptor signaling transcriptional program linked to immune evasion in human hormone receptor-positive breast cancer www.biorxiv.org/content/10.1101/2024.11....
Comprehensive single-cell aging atlas of healthy mammary tissues reveals shared epigenomic and transcriptomic signatures of aging and Cancer. #NatureAging #Aging #scisky #Medsky #News #Cancer
Open Access
www.nature.com/articles/s43...
Cancers adapt to their mutational load by buffering protein misfolding stress 🧪
doi.org/10.7554/eLif...
With holidays approaching I found this amazing person who makes #Pathology related art and gifts and wanted to share. Some of you make incredible images for your research. I'm always impressed with the art+science combo 🩷
lamellipodiumart.com
This is Ayla, named after my favorite book character (The Clan of the Cave Bear). She swims every day, no matter what. It's 57 degrees now, and the pool is frigid, but she just swam. Fitting, because Ayla in the book was famous for her daily swims, even breaking ice to get in #samandayla
In addition to science and gardening, I post about #samandayla and Ginger (no final # yet!) Front yard Paw Patrol reporting for duty, ready to alert about squirrels and falling leaves 🩷