Excited to share our joint efforts on the ratioCitron biosensor platform! 🔬✨
www.biorxiv.org/content/10.6...

Norito Tamura @mpiage.bsky.social from my lab enabled ratiometric citrate measurements in flow cytometry for population-scale, single-cell analysis.

Accelerating Leigh syndrome drug discovery through deep learning screening in brain organoids - Nature Communications Leigh syndrome is a severe, currently untreatable mitochondrial neurological disorder. Menacho, Okawa et al. developed a deep-learning drug screening pipeline in brain organoids, identifying azole com...

Super excited to share our latest work! In collaboration with Antonio del Sol, we show that brain organoids coupled with deep learning screening allow uncovering new repurposable drugs for the incurable mitochondrial disease Leigh syndrome.
www.nature.com/articles/s41...

Mitochondrial biology: Specialized powerhouses pack a punch A new study reveals that a specialized population of mitochondria in the Caenorhabditis elegans uterine anchor cell is remodeled and enriched in machinery needed for optimal local energy production to...

Check out our highlight of the most recent example of subcellular mitochondrial specialization in @currentbiology.bsky.social. Be sure to also check out the beautiful work from David Sherwood's lab

www.cell.com/current-biol...

📢Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️

biomed.news/bims-imicid/...

Lot's of exciting findings!

1) Purine salvage pathway protects CD8+ T cells from metabolic stress

2) Mitochondrial metabolism regulates the immunogenic responsiveness of dendritic cells

Synthetic microbial co-cultures for modular bioelectronic sensing in diverse environments - Nature Biotechnology Modular integration of bacterial strains expands the application range of whole-cell bioelectric sensors.

Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/...
via @biomednews.bsky.social | #livingmaterials #ELMs

includes research on: synthetic microbial co-cultures, programmable living surfaces, biohybrid robots, cell-in-shell metacells, protein-based bioinks, & more🧪

In Neurospora crassa.

ROMO1 and mitochondrial complex II/SDH are required for spare respiratory capacity and glucose homeostasis in mice - Diabetologia Aims/hypothesis Reactive oxygen species modulator 1 (ROMO1) is a highly conserved inner mitochondrial membrane protein that senses reactive oxygen species and regulates mitochondrial dynamics. ROMO1 i...

link.springer.com/article/10.1... New article from the group on the effects of aging and sex in beta cell glucose sensing - ROMO1 and complex II! Thanks to funders @diabetescanada.bsky.social and CIHR.

Cell-type-targeted mitochondrial transplantation rescues cell degeneration - Nature MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.

#WeekendRead! #SharingIsCaring! #CatchMeIfYouCan! Roska, Ayupov, Moreno-Juan &co show @nature.com that healthy #mitochondria can be efficiently delivered to distinct cell types via a selective #MitoCatch system that allows their intracellular transfer & protection of cells!

Guidance of cellular nematic elastomers into shape-programmable living surfaces Engineering living materials that autonomously morph into predetermined shapes holds potential for synthetic morphogenesis and soft robotics. Harnessing cellular tissues to self-organize and generate ...

www.science.org/doi/10.1126/...

Feels like this paper on protein-templated DNA synthesis by a natural enzyme warrants some comment.
So here's a 🧵. /1
www.science.org/doi/10.1126/...

How artificial intelligence is reengineering protein engineering Over the past decades, protein engineering has matured into a field of its own, driven by computational modeling and high-throughput wet lab experiments, with broad application in therapeutics, diagno...

www.science.org/doi/10.1126/...

Synthetic microbial co-cultures for modular bioelectronic sensing in diverse environments - Nature Biotechnology Modular integration of bacterial strains expands the application range of whole-cell bioelectric sensors.

doi.org/10.1038/s415...

"It made me wonder what I would design, for what purpose, with such technology" A book review of The future of species by Adrian Woolfson from the Royal Society of Biology website

Thanks to Professor Paul Freemont for his excellent review of my book #OnTheFutureOfSpecies in The Royal Society of Biology @rsb.org.uk journal The Biologist.

biologist.rsb.org.uk/future_of_sp...

Why do some cells produce more protein than others? Jasmine Tat (UCSD & Amgen) conducted a detailed study into the single-cell transcriptome, while measuring mAb production in single cells too with SEC-seq. Check out the preprint! doi.org/10.64898/202...

Early Career Faculty Program | Freeman Hrabowski Scholars | HHMI The Freeman Hrabowski Scholars Program offers comprehensive support to outstanding early career faculty committed to scientific excellence in their own research, and to fostering labs that expand the ...

This kind of stable, sustained support can transform a career: @hhmi-science.bsky.social's #FreemanHrabowski Scholars Program offers early career faculty up to $10M over 10 yrs, plus salary & benefits. Postdoc? This year's competition has a program for you too. Applications open 11/3! bit.ly/4vhC0LA

Development of PROTACs for targeted degradation of oncogenic TRK fusions Chromosomal translocations leading to the fusion of tropomyosin receptor kinases (TRKs) with diverse partner proteins have been identified as oncogenic drivers in many adult and pediatric cancers. Whi...

Proud to share our latest paper in @rscchembio.rsc.org, where we tackle oncogenic TRK fusions. Together, @sauravk05.bsky.social and Jiewei Jiang develop potent and selective degraders of the TPM3-TRKA fusion, a key cancer driver. pubs.rsc.org/en/content/a...

I am so excited to share our new findings with you! We provide the structural evidence for a direct protein-to-DNA information pathway, showing how a bacterial enzyme 'reads' its own structure to 'write' DNA. www.science.org/doi/10.1126/...

What good is modeling? Introducing biology students to theory Theory and empirical science should be in constant dialogue, but often find it hard to understand one another. Here we describe a graduate-level university course we developed to improve matters. The ...

Preprint: What good is modeling? Introducing biology students to theory - arxiv.org/abs/2604.13344 - how to teach and think about what modeling contributes to science. How does it fit into the scientific method? This is often misunderstood.

Britain Talks Trust in Science Commissioned by The Wellcome Trust Trust in science has long been one of the UK’s quiet strengths: a stable foundation beneath political cycles, economic shifts, and moments of national crisis. At fir...

Perhaps the most resonant point from Wellcome's new trust in science report:

'38% say there’s too much information available to know what’s true about science'

Some experts I speak to say the issue is that scientists have lost influence/voice, not trust
www.moreincommon.org.uk/our-work/res...

Why funders shouldn’t withdraw money from open access publishing Cancer Research UK’s decision to stop funding article processing charges marks a significant shift in how they approach open access. In its April 1st announcement (not an April Fool), the org…

"Much of OA policy is grounded in an ideology that treats everything as a market problem to be fixed through market instruments....neoliberal logic that gave rise to APCs"

Whether or not you agree with the main thrust of this article, the above is accurate. 1/2 www.samuelmoore.org/2026/04/14/w...

I do not agree with this reasoning, this is not the way!

Glucose Restriction Extends Chronological Lifespan of Budding Yeast by Avoiding Commonly Used Auxotrophic Marker Nutrient Starvation The survival period of yeast is determined by the type of nutrients they starved of. GR extends lifespan by avoiding auxotrophic starvation. Auxotrophic starvation causes degenerative cellular charac...

In the latest #Yeast research article, Yukinori Ozaki, Taku Ozaki and Qiu-Mei Zhang-Akiyama show that glucose restriction extends chronological #lifespan in budding yeast, while auxotrophic markers can induce abnormal cellular states under starvation.

👇
onlinelibrary.wiley.com/doi/10.1002/...

I’m looking for an automated way to read others’s scientific data without giving credit or acknowledgement, and also claim full credit for insights from it. And I want it to have a fitting name

OAI: say no more

I actually think there're going to be transformative uses of AI and science. But i'm not convinced that souped up dataset and literature searches are, in and of themselves, going to revolutionise the science and business of making and testing new pharmaceuticals.

A mechanism for adaptive genome regulation in cancer - Nature In this Perspective article, a theoretical framework for how the AP-1 family of transcription factors mediates cellular adaptation in cancer drug resistance is proposed.

a wonderful Perspective article www.nature.com/articles/s41...

Early Career Faculty Program | Freeman Hrabowski Scholars | HHMI The Freeman Hrabowski Scholars Program offers comprehensive support to outstanding early career faculty committed to scientific excellence in their own research, and to fostering labs that expand the ...

@hhmi-science.bsky.social's
#FreemanHrabowski Scholars Program offers early career faculty up to $10M over 10 yrs, plus salary & benefits

Stable, sustained support can transform your career:

Senior Postdoc? This year's competition has a program for you too. Applications open 11/3! bit.ly/4vhC0LA

Genome editing of blood stem cells to make therapeutic antibodies on demand!
+ applications for programming a factory of other proteins
New @science.org
science.org/doi/10.1126/...
science.org/doi/10.1126/...

Here are the computational biology parts of the Claude Opus 4.7 update today. Certainly impressive benchmark numbers, and likely to be an exciting model to work with in the real world if they hold up.

www.anthropic.com/news/claude-...
cdn.sanity.io/files/4zrzov...

Diversity-generating retroelements for programmable targeted hypermutagenesis - Nature Biotechnology Diversity-generating retroelements are engineered for directed evolution in E.coli.

🔈Paper out! We turned the most fascinating phage host-switch mechanism, diversity-generating retroelements, into a programmable mutagenesis tool, DGRec. You can perform targeted hypermutation of any 50-200bp sequence directly in vivo in E. coli www.nature.com/articles/s41...

Looks like a nice paper - "In addition, the growth of taxonomies containing many uncultured microorganisms, such as Verrucomicrobia, Planctomycetia, Acidobacteria, and Vicinimibacteria, was observed"

(minor note - 'Vicinimibacteria' is a typo, should be Vicinamibacteria)