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Organ of Corti from a neonatal mouse stained for F-actin (green), a marker for HC, Myosin 7a (blue) and a marker for cilia, Arl13b (Magenta), combined with a schematic representing gradient-driven compartmentalisation of epithelia and interactions between the compartments (coupling) as the underlying mechanism of this organisation of OC.

How does the #cochlea achieve its spiral shape? @prakash-patterns.bsky.social @earlab.bsky.social &co show that the expression of adhesion & polarity proteins pattern the #OrganOfCorti and drive the compartment-specific organisation to achieve the cochlea spiral @plosbiology.org 🧪 plos.io/4nmD8IW

#LatestPublication
Varsha from Dr. Raj Ladher’s lab finds that early inner ear fusion needs a hybrid EMT, where Grhl2/Sp8 remodel junctions to balance new contacts & tissue integrity.

This stunning image of an otocyst, taken by Varsha, featured on the cover!
bit.ly/4omQgOL

@earlab.bsky.social

#BestPaperAward

🎉 Congratulations to Raman Kaushik on being awarded the Zeeshan Khan Memorial Award 2025 (Runner Up) for the best paper published using the BLiSC Central Imaging Facility (CIFF) at the Bangalore Microscopy Course 2025.

@earlab.bsky.social @ncbsbangalore.bsky.social

#DBfeature #Drosophila 🪰

Slit-independent guidance of longitudinal axons by Drosophila Robo3

"A non-Slit-binding function of Robo3 Ig1 contributes to its axon guidance activity."

by Abigail Carranza, Timothy Evans et al
@timevansphd.bsky.social

sciencedirect.com/science/arti...

Cochlea generates patterns by interacting with neighbours We wanted to understand how cells arrange into precise patterns as the cochlea develops its spiral shape. We found that the cochlea is divided into smaller domains, each organising independently whil...

link.growkudos.com/1efpeb7d8n4 A short article is now available at Kudos on our work @earlab.bsky.social at @ncbsbangalore.bsky.social about how the cochlea generates its pattern.

The ear's organ of Corti as a model system of how developmental instructions coordinate across spatial scales so that tissues are sculpted reproducibly

📷 @prakash-patterns.bsky.social et al @tifr.res.in in @plosbiology.org

➡️ bpod.org.uk/archive/2025...

@earlab.bsky.social

Organ of Corti from a neonatal mouse stained for F-actin (green), a marker for HC, Myosin 7a (blue) and a marker for cilia, Arl13b (Magenta), combined with a schematic representing gradient-driven compartmentalisation of epithelia and interactions between the compartments (coupling) as the underlying mechanism of this organisation of OC.

How does the #cochlea achieve its spiral shape? @prakash-patterns.bsky.social @earlab.bsky.social &co show that the expression of adhesion & polarity proteins pattern the #OrganOfCorti and drive the compartment-specific organisation to achieve the cochlea spiral @plosbiology.org 🧪 plos.io/4nmD8IW

Organ of Corti from a neonatal mouse stained for F-actin (green), a marker for HC, Myosin 7a (blue) and a marker for cilia, Arl13b (Magenta), combined with a schematic representing gradient-driven compartmentalisation of epithelia and interactions between the compartments (coupling) as the underlying mechanism of this organisation of OC.

How does the #cochlea achieve its spiral shape? @prakash-patterns.bsky.social @earlab.bsky.social &co show that the expression of adhesion & polarity proteins pattern the #OrganOfCorti and drive the compartment-specific organisation to achieve the cochlea spiral @plosbiology.org 🧪 plos.io/4nmD8IW

#ResearchExplained
During embryo development, if cells fail to arrange or align correctly, organs could fail to function properly. Yet, cells somehow manage to find their place & align with remarkable precision.
Read here: bit.ly/46gbk2j
✏️Christeen Paulson

Role of Pcdh15 in the development of intrinsic polarity of inner ear hair cells Author summary Hearing, like other sensory modalities, is essential for animals to perceive and interact with their environment. The cochlea, the auditory sensory organ, develops under tight genetic r...

#LatestPublication
In a latest study published in PLOS Genetics, Ramankaushik and team from Dr Raj Ladher's lab describe a new role for protocadherin-15 in patterning the hair cell.
🎉Congratulations to the team!

journals.plos.org/plosgenetics...

InSDB-ISD Joint Meeting 2025 - the Node The Indian Society of Developmental Biologists (InSDB) is hosting our 2025 meeting from December 14–17 at IISER Berhampur. This year will be a joint

InSDB-ISD Joint Meeting 2025 thenode.biologists.com/insdb-isd-jo...

We are looking for a new @thembauk.bsky.social Anne Warner Research Fellow (5 year post) to develop an independent research group in the area of cell and molecular biology of marine organisms here in #Plymouth 🔬🦠🧫🧬 mymba.mba.ac.uk/job-listing....

Mona’s work is now online - check it and we’re Lokku g forward to any comments you have.

Prof. Raj Ladher, president-InSDB and faculty @NCBS_Bangalore, will talk about cochlear morphogenesis at InSDB-ISD 2025! Raj's lab works on understanding the mechanisms that control inner ear development

#InSDB25 #InSDBISD25
@earlab.bsky.social @ncbsbangalore.bsky.social

Excited to welcome Prof Sally Dunwoodie as an invited speaker for InSDB-ISD 2025!

Sally's work focuses on identifying the genetic and environmental causes of congenital defects. She is also the president of @intlsocdiff.bsky.social.

Register now: insdb.in/events/insdb...

#InSDB25 #InSDBISD25

Our spotlight in this lovely study from Nita et al., on Fgfr2 localisation to the cilia.

Pushing and pulling cells from chaos to order  - BioPatrika Researcher Spotlight - Pulling cells: Using a combination of experiments and mathematical modelling, we show that the tuned differences in the mechanical properties of junctions can organise cells int...

#authorinterview Anubhav Prakash @prakash-patterns.bsky.social from Prof Raj Ladher lab @earlab.bsky.social, NCBS @ncbsbangalore.bsky.social talks about his work on "Pushing and pulling cells from chaos to order" biopatrika.com/academia/res... @natcomms.nature.com

📢Good news, students and postdocs!

Early bird student/postdoc registrants for InSDB-ISD25, who are members of InSDB, will be eligible for a reimbursement of the registration fee. This is supported by @intlsocdiff.bsky.social !

Don’t miss out - register early here: insdb.in/insdb-isd-re...

📢Registrations are now open for InSDB-ISD 25!

This year, the meeting will take place at IISER BERHAMPUR from 15-17 December.

Join us this December!
Register here: insdb.in/insdb-isd-re...

@anups11.bsky.social
@earlab.bsky.social
@soniaqsen.bsky.social

#PhDone! 🎓 Congratulations Dr Surjit! 🎉
Surjit Singh Saini from Dr Raj Ladher's lab successfully defended his thesis!
🧵Scroll to learn about his work on understanding the development of inner-ear neurons 👂
(1/7)

@earlab.bsky.social

Junctional force patterning drives both positional order and planar polarity in the auditory epithelia - Nature Communications Sound is sensed in the cochlea through a precisely organised epithelium. Prakash and colleagues show cellular organisation results from differences in junction contractility, finding mechanics is suff...

#LatestPublication in @natcomms.nature.com by
Dr Raj Ladher & team show that fine-tuned junctional mechanics are vital for aligning polarity in chicken cochlea.

🎉Congratulations to the team!
@prakash-patterns.bsky.social @earlab.bsky.social

Read here: www.nature.com/articles/s41...

Epithelial fusion is mediated by a partial epithelial-mesenchymal transition www.biorxiv.org/content/10.1101/2025.04....

🌸This week RIKEN BDR is hosting researchers from the Bangalore Life Science Research Cluster (BLiSC), which includes @ncbsbangalore.bsky.social, inStem,
& TIGS, India. We are holding a joint meeting to further strengthen ties between BDR and BLiSC.
To the BLiSC delegation, welcome to Kobe!

#NewComicAlert!

Sharing the latest comic of our collaboration with @TinkleMagazine, featuring ecologist Dr Meghna Krishnadas!
Dr Meghna's lab studies plants & their interactions with other species & the environment!🌱

Free Download: bit.ly/ncbsxtinklec...

Happy Reading!

#scicomm #sciencecomics

Congrats to Varsha on a fantastic study investigating the fusion of the inner ear primordium.

www.biorxiv.org/cgi/content/...

The image is the official poster for InSDB25 featuring the speaker lineup and details of the program, along with an artwork that shows a busy cellular world. The logos of all organizers are also present.

InSDB25 is here!
This year’s meeting will be held in Dec at IISER Berhampur as a joint meeting with the International Society of Differentiation. We’ve got an incredible lineup and we can’t wait to share more details. Keep an eye out for more updates insdb.in/events/insdb...
@intlsocdiff.bsky.social

#Congratulations🎉
Abhinav Tyagi from Prof Uma Ramakrishnan's lab at NCBS is awarded the 2025 Smith Fellowship for pursuing post-doctoral research in applied conservation science at Purdue University, Indiana, USA.

Fellowship details: www.smithfellows.org/updates/anno...