Organ of Corti from a neonatal mouse stained for F-actin (green), a marker for HC, Myosin 7a (blue) and a marker for cilia, Arl13b (Magenta), combined with a schematic representing gradient-driven compartmentalisation of epithelia and interactions between the compartments (coupling) as the underlying mechanism of this organisation of OC.

How does the #cochlea achieve its spiral shape? @prakash-patterns.bsky.social @earlab.bsky.social &co show that the expression of adhesion & polarity proteins pattern the #OrganOfCorti and drive the compartment-specific organisation to achieve the cochlea spiral @plosbiology.org 🧪 plos.io/4nmD8IW

Organ of Corti from a neonatal mouse stained for F-actin (green), a marker for HC, Myosin 7a (blue) and a marker for cilia, Arl13b (Magenta), combined with a schematic representing gradient-driven compartmentalisation of epithelia and interactions between the compartments (coupling) as the underlying mechanism of this organisation of OC.

How does the #cochlea achieve its spiral shape? @prakash-patterns.bsky.social @earlab.bsky.social &co show that the expression of adhesion & polarity proteins pattern the #OrganOfCorti and drive the compartment-specific organisation to achieve the cochlea spiral @plosbiology.org 🧪 plos.io/4nmD8IW

Organ of Corti from a neonatal mouse stained for F-actin (green), a marker for HC, Myosin 7a (blue) and a marker for cilia, Arl13b (Magenta), combined with a schematic representing gradient-driven compartmentalisation of epithelia and interactions between the compartments (coupling) as the underlying mechanism of this organisation of OC.

How does the #cochlea achieve its spiral shape? @prakash-patterns.bsky.social @earlab.bsky.social &co show that the expression of adhesion & polarity proteins pattern the #OrganOfCorti and drive the compartment-specific organisation to achieve the cochlea spiral @plosbiology.org 🧪 plos.io/4nmD8IW