Our study about splicing modulating compounds is out!
Molecules like Branaplam tweak exon inclusion. We describe how RNA structure and sequence dependencies shape exon selectivity. We're even able to reprogram the specificity by co-treatment with modified U1 snRNAs.
www.biorxiv.org/content/10.1...
I sometimes overhear conversations about tool choice in bioinformatics, where implementation language is stated as the primary criterion. Such thinking stands in the way of scientific quality and productivity. It is a form of self-harm.
What should one really care about?
(1/5)
This paper is a great example of the use of multiomic/multimodal data from patient cohorts for target identification. All evidence pointing towards ZNF469 as a regulator of collagen in liver fibrosis. Lots of potential here! insight.jci.org/articles/vie...
Plot produced with exactplot
xp_compose_plots( xp_text("Welcome to \\texttt{exactplot} with \\LaTeX{} support", x = 1, y = 2, fontsize = xp$fontsize_large, fontface = "bold"), xp_text("A) Flipper length vs.\\ beak size", x = 1, y = 8), xp_plot(scatter_plot, x = 0, y = 12, width = 80, height = 40), xp_text("B) Beak sizes", x = 84, y = 8), xp_plot(beak_lengths, x = 82, y = 12, width = 58, height = 40), xp_text(density_formula, x = 99, y = 12, fontsize = xp$fontsize_small), width = 140, height = 52, keep_tex_file = FALSE, filename = "example.pdf" )
I just uploaded the first version of {{exactplot}} to github.com/const-ae/exa... 🎉
It produces figures with consistent font size, Latex labels, and millimeter-perfect layouting. It's an alternative to patchwork with less elegant syntax but much more flexibility.
#rstats
CSAMA 2025 flyer
Do you want to learn more about the statistical analysis of proteomics, metabolomics, single-cell and spatial transcriptomics? Do you want to up your game with R and Bioconductor? All of this while enjoying summer in the beautiful Italian Alps? Join us for the 21st edition of CSAMA July 6-11!
All the videos from the #cdsb2024 workshop are available now on our @cdsbmexico.bsky.social YouTube channel. If you’re interested in learning about creating R packages go take a look! All the materials are available in Spanish youtube.com/@cdsb
New method for identifying spatially variable genes in spatial transcriptomics.
We use spectral graph theory to extract 1D curves related to tissue morphology, creating a more relevant coordinate system. Improves sensitivity.
with @PhillipNicol et al.
www.biorxiv.org/content/10.1...
Bioconductor 3.20 is released! 🎉🌟
Thanks to all developers and community members for contributing to the project! 🙌
👉 See the full release announcement: bioconductor.org/news/bioc_3_...
#Bioconductor #DataScience #Bioinformatics #OpenSource
Hello bluesky!