Which transcription factors control transposable element expression during zygotic genome activation?
Gain-of-function screen by @metorrespadilla.bsky.social and coworkers identifies TBP as direct regulator of mouse endogenous retrovirus-like elements
link.springer.com/article/10.1...
Just out! 👀 for TFs that regulate TEs.Clara's work with @tamas-schauer.bsky.social @marliesoomen.bsky.social @palmrinmoy.bsky.social and bluesky-less lab members 🌎 identifies TBP as a regulator of specific ERVL class: MaLRs in 🐭embryos -as always -feedback welcome👍
link.springer.com/article/10.1...
Very grateful to everyone who made this work possible. I feel incredibly lucky to have worked with such an amazing team.
Special thanks to: Jakob El Kholtei, KJ Jenie, @mcolomerr.bsky.social, and of course our wonderful collaborator Bogdan Bintu and my mentor @schierlab.bsky.social
Incredibly proud to share our new preprint, lead by the Incomparable Rithika Sankar.
Here we temporally dissect the role of FACT in mES cells, finding that FACT loss drives progressive deterioration of chromatin architecture, leading to transcriptional collapse.
www.biorxiv.org/content/10.6...
Our internal organs are evolutionary marvels. New technologies are transforming our understanding of the evolution of vertebrate organs. You can find more by reading here:
rdcu.be/e5EgU
#EvoBio #EvoDevo 🐟🦎🐢🦇🐊🦜
I had a lot of fun putting this together with @suminkim.bsky.social and @andersshansen.bsky.social! Glad to have had the chance to work on it!
I am also (i) very stressed, (ii) very thrilled and (iii) on the job market
PEOPLES OF EARTH: BE PREPARED 🧪
New preprint!! 🚨 Did you know that many vertebrate species determine sex based on environmental conditions rather than chromosomes? Some turtles, like Trachemys scripta, rely on temperature. We learned more about how this happen molecularly.👇
www.biorxiv.org/content/10.6...
The final (and my favorite) chapter of my PhD is now officially published!
Extremely grateful to all our collaborators, especially to @marisepp.bsky.social and @tyamadat.bsky.social for their hard work, and to @steinaerts.bsky.social and @kaessmannlab.bsky.social for their guidance and advice!
It is finally out! If you are interested in TE-derived CREs, and newly described, but evolutionary old KZFP-TE mechanistic modalities, read it at www.cell.com/cell-reports....
Thankful to everyone who took part in this work, namely @orpsf.bsky.social and other @trono-lab.bsky.social members. 🫀🧬✨
Very excited to receive this award and truly grateful to the @bscb-official.bsky.social who have been supporting me throughout my postdoc since I moved to the UK!
Cow Tools!
We have lived alongside cows for nearly 10,000 years.
We breed them and exploit them
It is now, only now, that we have discovered THEY CAN USE TOOLS
Here I describe our study
(paper) www.sciencedirect.com/science/arti... in @currentbiology.bsky.social
with @auersperga.bsky.social
Work by the 4D Nucleome Consortium, led by Job Dekker, PhD, reveals a systematic map of the structure and function of the human: direc.to/ooab
#genome @jobdekker.bsky.social @hhmi-science.bsky.social @nature.com @marionicodemi.bsky.social @creminslab.bsky.social @gladstoneinst.bsky.social
I’ve been so lucky to be part of the PI Programme by @biologists.bsky.social this past year and met so many incredible people! Come hear us talk about what keeps us up at night this Wednesday!
"It is crucial for us, young scientists, to come together from different countries and build a network," says Marlies Oomen, EMBO Postdoctoral Fellow at Helmholtz Munich. 🧪
www.embo.org/people/global-mobility-s...
#networking #LifeSciences #research #funding
Development presents… Wednesday 14 January 15:00 GMT/UTC Chair: Priti Agarwal Chee Kiang (Ethan) Ewe Tel Aviv University ‘Neuronal oversight of germline small RNAs prevents heat-induced sterility in Caenorhabditis elegans’ Max Farnworth University of Bristol ‘How the evolution of spatial foraging shaped centres of cognition in Heliconiini butterflies’ Sonya Widen IMBA, Vienna BioCenter ‘“Unpacking” eukaryotic horizontal gene transfer: Mavericks transfer novel “cargo” genes across the globe’ #DevPres | @dev-journal.bsky.social thenode.biologists.com/devpres
Join us next week for #DevPres to hear 3 of our PI fellows talk about the environment & evolution
14 January 15:00 GMT/UTC
With talks from @ethanewe.bsky.social, @maxfarnworth.bsky.social & @sonyawiden.bsky.social, chaired by @pritiagarwal.bsky.social.
us02web.zoom.us/webinar/regi...
#DevPres
Happy to share that my postdoc work with @jobdekker.bsky.social is out!
rdcu.be/eWHD2
We characterize interphase chromatin folding programs with distinct modes of mitotic inheritance and identify the chromosome-intrinsic capacity to form a microcompartment of active CREs during mitotic exit.
After a long journey, I'm happy to share that my PhD work is finally published in Nature Communications. Grateful to all my co-authors!
🚨Our story is published! Same bones but + dissection of MERVL’s role integrating signals from #ZGA factors, & + about pathological DUX4 activation of NOXA #TEsky. Thanks to all revs for their helpful comments improving the ms. Even #rev3 - until they ghosted us 😜
www.science.org/doi/epdf/10....
Exciting new paper out! @allanaschooley.bsky.social and Sergey Venev led this project that let to the discovery of two chromosome folding programs: one inherited via mitotic chromosomes and one mitotic inherited through the cytoplasm!
www.nature.com/articles/s41...
Apply for Development's Pathway to Independence programme
The programme aims to support a small number of researchers in the fields of developmental biology, stem cells and regeneration as they transition from postdoc to group leader. Read more ⬇️
thenode.biologists.com/apply-for-de...
I recommend any Developmental biologists planning to start the road to becoming a PI next year to apply! The help and guidance you will receive are valuable but being a part of a cohort of people living through the same experiences is worth its weight in Gold!
Join us at SMBE26! We are in a golden period for understanding the evolution of gene regulation.
A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists!
www.nature.com/articles/s41...
Just got back to Munich after a wonderful Pathway to Independence retreat to the @biologists.bsky.social @dev-journal.bsky.social headquarters. Highly recommend applying to the program; you will find an amazing group of peers and get training + support throughout your transition to independence!
Anzy Miller, Martina Cerise, Giulia Paci, Max Farnworth, Sonya Widen, Marlies Oomen, Ethan Ewe, Joaquín Navajas Acedo and Toshimichi Yamada.
We were delighted to welcome our most recent Pathway to Independence (PI) fellows to our offices at @biologists.bsky.social for leadership training.
Find out more about our PI fellows and how to apply here:
journals.biologists.com/dev/pages/pi...
Application deadline: 2 February 2026.
We are sitting around a busy, long dinner table, all wearing color paper crowns and smiling
Great day with these certified knuckleheads that are absolutely the best (and future) of their fields 🧪 @ethanewe.bsky.social @marliesoomen.bsky.social @giuliapaci.bsky.social @amjeve.bsky.social @maxfarnworth.bsky.social @anzymiller.bsky.social Martina and Toshi
Applications are open for @dev-journal.bsky.social 2026 Pathway to Independence (PI) programme, supporting postdocs applying for group leader positions:
Mentoring
Profile raising
Leadership training
Network building
Spread the word...
www.biologists.com/grants/devel...
Pathway to Independence Support postdocs on the job market Line drawing of a person at a bench transitioning to working at a desk Development
Apply for our Pathway to Independence (PI) programme, supporting postdocs in #devbio and #stemcell research during the transition to their first group leader position: www.biologists.com/grants/devel...
Application deadline: 2 February 2026.