*postdoc job alert* Are you interested in theory and experiment for time-resolved cryo-EM? If so see below 👇 a collaboration between the Crick and the Flatiron Institutes 💻🔬

Introducing ROCKET: An Upgrade to AlphaFold That Learns From Raw Experimental Data Introducing ROCKET: An Upgrade to AlphaFold That Learns From Raw Experimental Data on Simons Foundation

#FlatironCCM researchers have developed a new tool called ROCKET that extends the capabilities of AlphaFold by directly learning from raw experimental data: https://bit.ly/4dUTZkG #science #math

Episode 32 - Robert Best, Sonya Hanson, Xuhui Huang: Driving the Future of Biophysics. What’s Next in Theory and Computation? - Phase Space Invaders (ψ) With the convergence of data, computing power, and new methods, computational biology is at its most exciting moment. At PSI, we're asking the leading researchers in the field to discover where we're ...

Celebrating #BiophysicsWeek T&C partnered with Phase Space Invaders podcast: Robert Best @sonyahanson.bsky.social @xuhuihuangchem.bsky.social and host @milosz-wieczor.bsky.social Episode 32: Driving the Future of Biophysics: What’s Next in Theory and Computation?
www.buzzsprout.com/2313153/epis...

Check out our Flatiron team @BPS2026!

How can we extract unbiased transition rates from ligand-unbinding Random Acceleration MD (RAMD) simulations? Our new paper lays out the theoretical framework behind RAMD. Take a look! doi.org/10.1063/5.03... @benoitroux.bsky.social @yiweiding.bsky.social & Alessia Ghidini #MD #drugdiscovery

#BPS2026 The T&C subgroup is hosting a fun event on Saturday evening, Feb 21st 🎉 Open bar for 2 hours + food! Tickets are selling fast, so sign up soon: www.biophysics.org/2026meeting/...

Go use cryojax ! It's awesome! I can't wait to see what people do with it.

I finally made my webpage, check it out: pilarcossio.org

Happy new year!!🎆 & checkout our new preprint exploring optimal transport for cryoEM parameter optimization:

…and it works on real cryo-EM data!

To avoid unphysical structures, we incorporate a physics-based prior:

We can escape local minima and robustly explore the conformational landscape encoded in cryo-EM images.

Cryo-electron microscopy ensemble optimization using individual particles and physical constraints Biomolecules are inherently dynamic, and understanding their conformational ensemble distributions is essential for understanding their dynamics and biological roles. Cryo-electron microscopy (cryo-EM...

Happy to share our cryoEM Ensemble Optimization method! 🎉It infers optimal structures and their weights directly from individual cryoEM images - no maps just physics! with David Sliva-Sánchez, @erikhthiede.bsky.social & Roy Lederman www.biorxiv.org/content/10.6...

Checkout our cryo-EM simulator in JAX: paving the way for cryo-EM probabilistic modelling & statistical structural biology #cryoEM with @m0bri3n.bsky.social @miroastore.bsky.social + Harvard, Flatiron & Cornell!

**Job Alert** Exciting postdoc position available: theoretical and experimental cryo-EM studies of flexible biomolecules. Competitive salary, collaborative environment at NYSBC and Flatiron Institute. Please share!! and contact: pcossio@flatironinstitute.org

Submit your BPS T&C subgroup nominations::!!

*Job Alert*: postdoc positions available @flatironinstitute.org in Computational Mathematics: apply.interfolio.com/173401

Check out our latest preprint for the first community #cryoEM heterogeneity challenge 🎆🎇 @sonyahanson.bsky.social @miroastore.bsky.social + method developers and participants! @flatironinstitute.org

#BPS2026 submit your nomination for the Theory and computation awards!!!

Check out our recent preprint 👇on counting particles to estimate populations in #cryoem: noise can bias the estimates; with Luke Evans & a great team.

If you care about how to use cryoEM to estimate conformational ensembles and populations of different states you should read this from @pilarcossio.bsky.social and team ❄️ 🔬

#APSSummit25 come to our session in generative modeling and machine learning in chem phys! Chaired with @GrantRotskoff and an amazing set of speakers 🎉 starting Thursday 11:30am room 204A

#BPS2025 waiting for the national lecture 🥳 @giuliapalermo.bsky.social @labvanni.bsky.social @sriraksha.bsky.social @sesamedusa.bsky.social

Thanks to all who attended the #BPS2025 #cryoem symposium yesterday, and the happy hour last night!

We heard some superb science at the symposium and had some great discussions which were continued in the evening.

And congratulations to Dr. Elizabeth Wright, our inaugural Almeida Award winner!

Nice time catching up with folks from @foldingathome.org at #bps2025

We are hiring a Flatiron Research Fellow in the Structural Molecular Biophysics team! Experience with cryoEM and/or membrane protein simulations are a plus! Happy to chat in person with anyone at #bps2025 ! apply.interfolio.com/160227

Checkout the Flatiron Institute Structural and Molecular Biophysics at #BPS2025 @sonyahanson.bsky.social @miroastore.bsky.social @samsl.io

For those at #BPS2025 come to the #cryoem subgroup symposium Saturday 8:30-12:30am Room 515B. 🔬❄️There are also tickets available for the happy hour!

So happy that you are visiting! See you soon!

Looking forward to great science and cool scientists at #BPS25 next week

And before that a stopover in NYC 🍎 to give a talk at the Flatiron Institute and meet @pilarcossio.bsky.social and colleagues