Check out the Insights piece from A Blumenthal & L Dominguez Cadena on our discovery of CCDC134’s role in Gp96 stability and TLR biogenesis.
Many thanks to the authors for discussing our work broadly, integrating recent studies by Rohatgi and Locher/Kaelin labs, and highlighting key open questions.

Thrilled to see our recent paper on CCDC134 highlighted in @jem.org !
Grateful for the opportunity to contribute to this field and engage in meaningful discussions!

We are excited to announce the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors, Oct 1-2 2025, Lausanne, Switzerland.

Registrations open March 1 - Attendance limited to 150 participants.

More info: wp.unil.ch/immunobiolog...

#ImmunoSky

Sterile- or pathogen-induced endolysosomal damage activate the NLRP6 inflammasome in human intestinal epithelial cells NLRP6 controls host defense against bacteria and viruses in the gastrointestinal tract by a poorly understood mechanism. Here, we report that NLRP6 forms an inflammasome upon endolysosomal damage caus...

Check out our latest pre print! Alexandra and colleagues show that the enigmatic inflammasome receptor, NLRP6 is activated by sterile and pathogen induced endolysosomal damage. Hot off the press!

www.biorxiv.org/content/10.1...

I’m thrilled to share our latest work from the @rebsamenlab.bsky.social, now published in @naturecomms.bsky.social!

For the first time, we reveal the importance of the SLC15A4-TASL-IRF5 pathway in vivo.

It was a great pleasure to contribute to this project!

📢We're recruiting📢

Our lab at the University of Lausanne is looking for a postdoctoral associate to study #nucleotide metabolism in physiology and cancer in vivo!

Please share

#uridine #cancermetabolism #immunometabolism

@unil.bsky.social

🔗(PDF): www.jourdainlab.org/wp-content/u...

Special thanks to the @rebsamenlab.bsky.social, @brozlab.bsky.social, the Majer group at @mpiib.bsky.social and the support of all our colleagues at @dib-unil.bsky.social!
#TLR
#screen
#CRISPR
#ImmunoSky

I’m proud to share the latest work of my PhD thesis, just published in @jexpmed.bsky.social! You’ll find how CCDC134 controls TLR biogenesis through the ER-chaperone Gp96, a very exciting discovery!

rupress.org/jem/article-...

More info here: bsky.app/profile/rebs...