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Posts by Diana Khoromskaia

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All you ever wanted to know about how to analyse the nematic nature of cellular tissues is right here 👀👇🏼!

Bonus #1: we did it for many cell types and uncovered unexpected defect behavior 🐌

Bonus #2: for theoreticians looking for parameter values for your simulation🧑🏼‍💻

tinyurl.com/2s399yen

1 day ago 34 15 4 0

Just published in @science.org 🚀

By controlling how cells align, we show that living nematic tissues can be programmed to generate forces and fold into predictable 3D shapes.

A new platform for tissue engineering and the design of smart active materials! 🫆

www.science.org/doi/10.1126/...

6 days ago 80 32 8 2

Amazing! Congratulations, Pau!

6 days ago 1 0 0 0
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Mechanochemical coupling regulates defect dynamics in active nematics Active nematics offer a versatile continuum framework for nonequilibrium collective phenomena, such as collective cell migration and tissue morphogenesis. However, the dynamic evolution of active…

New study on topological defects develops a mechanochemical model integrating morphogen concentration and hydrodynamic flow, reproducing experimental collective motility and revealing viscosity, activity, and alignment strength as key factors governing defect-mediated transport.

2 weeks ago 4 3 0 0
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The CiM-IMPRS PhD program in #Münster is offering 16 #PhD positions in Life and Natural Sciences! Perform cutting-edge resesearch in a vibrant international setting and lively city! Apply by May 1st, 2026 - see www.uni-muenster.de/CiM-IMPRS/ap...
@uni-muenster.de
@mpi-muenster.bsky.social

1 month ago 12 12 0 1
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Deciphering mechanical determinants of morphological evolution A comparative analysis of cnidarian larval morphogenesis combined with active surface theory identifies a set of mesoscale mechanical modules that predict species-specific shapes. Manipulating these m...

Congratulations Guillaume #Salbreux and collaborator @aikmi.bsky.social groups for your latest publication in @cellcellpress.bsky.social: Deciphering #mechanical determinants of morphological #evolution @genevunige.bsky.social @sciencesunige.bsky.social #UNIGE
👉 www.cell.com/cell/fulltex...

4 weeks ago 7 4 0 0
Pictured are cross sections of larvae from Nematotstella (left) and Aiptasia (right), with the sliders underneath representing the mechanical modules which combine to give rise to an organism's mechanotype. Credit: Daniela Velasco/EMBL

Pictured are cross sections of larvae from Nematotstella (left) and Aiptasia (right), with the sliders underneath representing the mechanical modules which combine to give rise to an organism's mechanotype. Credit: Daniela Velasco/EMBL

A sea anemone looks very different from a coral, despite belonging to the same broad biological group.

A new study from EMBL researchers and their colleagues sheds new light on how diversity arises in body shapes in the animal world.

www.embl.org/news/science...

1 month ago 29 9 0 2

🔥Exciting new paper from the Ikmi group @embl.org! The authors identified a set of mesoscale mechanical modules that can be used to predict species-specific shapes by combining a comparative analysis of cnidarian larval morphogenesis with active surface theory #morphogenesis #cnidaria

1 month ago 7 3 0 0
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Amazing to see this study finally out! Proud to have contributed to the active surface modelling of cnidaria morphogenesis across species and huge congrats to Richard, Nicolas, and all authors! #morphogenesis #activematter #nematicorder #evolution

1 month ago 20 2 1 0
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Deciphering mechanical determinants of morphological evolution A comparative analysis of cnidarian larval morphogenesis combined with active surface theory identifies a set of mesoscale mechanical modules that predict species-specific shapes. Manipulating these modules reprograms morphology, revealing how variation in tissue-scale mechanics underlies morphological diversity.

Now online! Deciphering mechanical determinants of morphological evolution

1 month ago 12 4 0 0
•	Figure 1 of the article: Fig. 1. Phase diagram of tissue material phase transitions and examples. (A) Schematic diagram showing how continuous changes in microscopic dynamics (control parameter) lead to abrupt, drastic, and non-linear shifts in macroscopic properties that define the material response (order parameter). (Aa-Ab) Exemplary phase transitions as traditionally described in non-living matter, e.g. for water (Aa), as well as in living matter, e.g. for embryonic tissues (Ab). Yellow areas indicate fluid-like tissues and regimes. Blue areas indicate solid-like tissues and regimes. Magenta dashed line depicts the critical point. Orange line marks particle and cell trajectories.

• Figure 1 of the article: Fig. 1. Phase diagram of tissue material phase transitions and examples. (A) Schematic diagram showing how continuous changes in microscopic dynamics (control parameter) lead to abrupt, drastic, and non-linear shifts in macroscopic properties that define the material response (order parameter). (Aa-Ab) Exemplary phase transitions as traditionally described in non-living matter, e.g. for water (Aa), as well as in living matter, e.g. for embryonic tissues (Ab). Yellow areas indicate fluid-like tissues and regimes. Blue areas indicate solid-like tissues and regimes. Magenta dashed line depicts the critical point. Orange line marks particle and cell trajectories.

Tissue phase transitions in development: more than just mechanics

In this Review, @nicolettapetridou.bsky.social, @laura-rustarazo.bsky.social and @karengrace12.bsky.social discuss tissue phase transitions during development: doi.org/10.1242/dev....

2 months ago 24 4 0 0

We summarised the many roles of material phase transitions in development (and they are not just mechanical 🤔)

2 months ago 31 9 0 0
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Tissue phase transitions in development: more than just mechanics Summary: Tissue material phase transitions are classically thought to regulate tissue deformability. This Review emphasises their unexpected roles in directly influencing growth and patterning signall...

Excited to share our new review in @dev-journal.bsky.social on tissue phase transitions during development!

@karengrace12.bsky.social @nicolettapetridou.bsky.social

🔗 doi.org/10.1242/dev....

2 months ago 72 26 2 2
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New preprint @biorxiv-devbio.bsky.social by Harshath Amal and colleagues from our lab @uni-muenster.de shows how a BMP #morphogen gradient is translated into graded junctional permeability by tuning adhesion and actomyosin contractility in #Drosophila
See tinyurl.com/yhbwd9xh
@sfb1348.bsky.social

2 months ago 85 29 4 1
LinkedIn This link will take you to a page that’s not on LinkedIn

My lab @cri-utsw.bsky.social is looking for a highly motivated postdoct interested in mechanobiology!

We are building a highly collaborative and interdisciplinary team working on how mechanical forces shape immune and cancer cell behavior.

Come do cool science with me!

lnkd.in/gKEXWUGy

2 months ago 11 10 0 0
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Join us today 2-3pm online.

Sign up for the Zoom link here: forms.gle/Mt3y7HQXetrb...

2 months ago 2 1 0 0
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Isasti-Sanchez, J., Münz-Zeise, F., Lancino, M., & Luschnig, S. (2021). Transient opening of tricellular vertices controls paracellular transport through the follicle epithelium during Drosophila oogenesis. Developmental Cell, #EpithelialMechanics doi.org/10.1016/j.de...

3 months ago 7 1 0 0
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Cellular Interfaces reloaded: Join us for the @sfb1348.bsky.social International Meeting on „Mechanochemical signals at cellular interfaces" in Münster from May 27–29, 2026.
Registration opens in February! Limited spots – first come, first serve! More info: tinyurl.com/ypyzd23w
@uni-muenster.de

3 months ago 16 14 0 2
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How does signalling control cortical tension?

Using optogenetics and AFM, we show that myosin recruitment and cortical tension increase proportionally with RhoA signalling.

More here:
www.biorxiv.org/content/10.6...

Super work by Pierre Bohec with Guillaume Salbreux and @dianakhorom.bsky.social

4 months ago 56 11 0 1

New preprint out! We use optogenetics, AFM, and active surface modelling to link signalling ⚡ → mechanics ⚙️ → cell shape 🔵

3 months ago 8 1 0 0

Congratulations, Wolfram!

3 months ago 0 0 1 0
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Looking forward to an exciting @sfb1348.bsky.social seminar with Lucia Baldauf @ucl.ac.uk on January 8, 2026. She will speak about "Illuminating Forces in Living Tissues". More info: www.uni-muenster.de/SFB1348/en/i... Everyone's welcome!

3 months ago 8 4 0 1
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Control of cellular cortical tension and shape by RhoGTPase signalling Shape changes are ubiquitous in biology, from cytokinesis at the single cell scale to tissue-scale morphogenesis involving coordinated changes in hundreds of cells. In all cases, morphogenesis is powe...

www.biorxiv.org/content/10.6...

4 months ago 8 2 0 0

My lab is hiring a postdoc (ERC funded)! If you're interested, get in touch!

4 months ago 59 66 3 2
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🚨 PhD Position Available 🚨
I’m recruiting a PhD student to join my lab at the Multiscale Imaging Centre (MIC), Münster, Germany.

www.bischofflab.com/jobs

Fully funded ✅
#Cellbio #Morphogenesis #Microscopy
#Drosophila #PhD
(Details Below)

Original Posting:
stellen.uni-muenster.de/jobposting/d...

4 months ago 44 35 2 4

Congratulations, Adrien! Exciting news! 👏

4 months ago 1 0 1 0
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#LivingArchitectures
We put cells and cytoskeleton filaments on the architecture of the musée d'Orsay.
www.musee-orsay.fr/fr/agenda/ev...
Scientists of the #CytoMorphoLab adapted their protocols to illustrate the questions that keep them awake at night.
-> Two shows on the 24th and 25th of January.

4 months ago 308 103 19 9
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📢Internships on cellular nematics!

🔬Come for the pretty images, stay for the cool physics: each project combines in vitro experiments with advanced microscopy and image analysis.

📧Feel free to DM or email me with any questions.

4 months ago 14 15 1 0
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4 months ago 17 5 0 0
The historc city center of Münster, famous for the Peace of Westphalia!

The historc city center of Münster, famous for the Peace of Westphalia!

2/2 If you’re into #cellbio, cellular interfaces, #mechanobiology, #membranes, anything related, come to Münster, Germany, May 27–29!

www.uni-muenster.de/SFB1348/en/i...

Please spread the word. It’s a fantastic (and FREE!) meeting. And while you’re here, explore Münster… it’s worth it.

#Science

4 months ago 17 11 0 0