🔬 How do core facilities bridge biology, imaging, and AI? Read this interview with Przemek Krawczyk, a microscopy specialist & group leader at Amsterdam UMC, to learn how he and his team push boundaries between data, imaging & biology. ⤵️
www.eurobioimaging.eu/news/meet-pr...

Check out our new release on BioRxiv
co-lead by @pm-mueller.bsky.social

👉 rb.gy/lnrizk

special🙏 to
Severine Kunz #MDC
@leventallab.bsky.social
@andimicroscopy.bsky.social
@ewerslab.bsky.social and Kedar Narayan @NCI CCR VolumeEM

Are the days of discovering new cellular structures over?? /1

The latest #SPECIALISSUE of #CYTOSKELETON is now out! CYTOSKELETAL REGULATION OF MITOCHONDRIAL DYNAMICS. Check out the entire issue here: onlinelibrary.wiley.com/toc/19493592... . #openaccess #mitochondria #actin #septin

Attention #Arp2/3 Fans!!! Check out this #openaccess paper in #CYTOSKELETON. Engineering and Characterization of a Fluorescent Fission Yeast Arp2/3 Complex for Single Molecule Mechanistic Investigations. onlinelibrary.wiley.com/doi/10.1002/...

Want to learn #Python for #ImageAnalysis? 🐍 Supported by the #EVOLVEproject, four #EuroBioImaging Nodes are offering a distributed training course for beginners on Python - it's free! Join the course in 4 in person locations - 🇬🇧 🇵🇹 🇨🇿 🇸🇪
Apply before April 15⤵️
www.eurobioimaging.eu/events/evolv...

#CYTOSKELETON #SPECIALISSUE submission deadline is approaching! Assembly and Maintenance of Myofibrils. Deadline is April 1, 2026. Submit today. It's #Free to #publish in CYTOSKELETON.

Figure showing that pillar-induced confinement results in loss of Golgi ribbon integrity. hMSCs were cultured on polystyrene pillar-enhanced surfaces, as well as on unconfined control surfaces, for 24 h and stained for GM130, α-tubulin, F-actin and DNA to visualize the Golgi morphology, microtubule network, F-actin organization and nuclei, respectively. (A,B) Representative images of two biological replicates showing that confinement introduced by the presence of micro-pillar patterns results in reorganization of the Golgi architecture, characterized by a varying level of compaction of the Golgi complex. Scale bars: 20 μm. (C–H) Heterogenous distribution of Golgi structural integrity and positioning on pillar D. Representative images of two biological replicates. Scale bars: 20 μm.

Juul Verbakel and Jan de Boer interrogate the impact of microscale topography on Golgi morphology and function.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...

📣 Calling #cytoskeleton & #cellbiology #researchers!
CYTOSKELETON seeks Editorial Board members
Assoc Prof+ required
Apply by Apr 1, 2026
Submit:
forms.office.com/r/Yvr4RxBTHb

Save the date!
We have an exciting conference coming up next year for the UK Mechanobiology community!

Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant properties - Nature Materials Vocal fold cancer tumours lose some of their malignant traits when mechanically stimulated by physiological stretch or vibrations, mimicking the opening and closing of vocal folds and phonation.

What music should we play to our cells? This was the start of an amazing journey from @ivaskalab.bsky.social at @turkubioscience.bsky.social with Jasmin Kaivola and collaborators @sarawickstrom.bsky.social and others to explore larynx cancer mechanosensitivity!

www.nature.com/articles/s41...

CELL MIGRATION LAB We study cell migration in health and disease

🚨 We are hiring TWO postdocs to join the Cell Migration Lab (cellmig.org) 🇫🇮 as part of the new Centre of Excellence in Immune–Endothelial Interfaces (IMMENs).
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶

Really excited to share this work from @zech-lab.bsky.social - brilliant work by all, with the bulk of it by @milancollins.bsky.social ! Enjoy!

Great work led by @milancollins.bsky.social and guided by @drlornayoung.bsky.social

We’re excited to share our latest preprint! We identify SKT, a mechanosensitive adhesion protein that recruits mTORC2 to cell–matrix adhesions, linking metabolic demand to matrix stiffness. Disrupting this axis strongly inhibits PDAC tumor growth. shorturl.at/V0tpK

MRC funding update An update on MRC funding during UKRI’s transition, what’s changing, and the next steps for paused opportunities and reopening timelines.

What a waste of my (and many others) time applying last Sept!

"we unfortunately expect to make a reduced number of awards to applications currently being assessed by our four research boards and developmental pathway funding scheme."

www.ukri.org/blog/mrc-fun...

I am very excited to share this preprint which has been my main postdoc project! We identified leupaxin as a negative regulator of durotaxis via paxillin-FAK inhibition in MDA-MB-231 brain and bone tropic metastatic variants. www.biorxiv.org/content/10.6...

@mathildemathieu.bsky.social @ivaskalab.bsky.social New discovery from us! Leupaxin, a paxillin family member typically expressed in immune cells, negatively regulates durotaxis and mechanoresponsiveness in metastatic breast cancer cell variants and in cells cultured on soft ECM lnkd.in/diEk8DSR

UK’s £8bn research fund faces “hard decisions” as it pauses new grants UKRI boss Ian Chapman said it had been told by the government to

Helpful update into UKRI and research council funding changes from Zoe Kleinman @zsk.bsky.social

But please more focus on 2 things...

1) Immediate effects (eg funding decisions expected in March)

2) Likely disproportionate effects on early career scientists

www.bbc.co.uk/news/article...

Cell-matrix mechanosensing and cellular metabolic demand are linked through SKT and mTORC2 www.biorxiv.org/content/10.64898/2026.02...

🔬UK researchers: Access cutting-edge bioimaging tech + expert support with our User Access Fund!

💷 £5k for imaging
💷 £2k for image analysis

Choose from 6 top UK facilities, contact them, then apply!

rms.org.uk/user-access-fund

⏰ Next deadline: 31 March
✅ Decision in 4 weeks

Pls share!

Laboratory Engineer (Senior), in Advanced Imaging, 1.5.2026-31.12.2028

🚨 Job Alert! 🚨

We have an opening at our Microscopy Core Facility in Turku 🇫🇮.
If you love imaging 🔬 and helping scientists succeed, we want you! 👇

abo.rekrytointi.com/paikat/index...

#Microscopy #ScienceJobs #CoreFacility #Imaging
@turkubioscience.bsky.social

Laminin N-terminus α31 regulates corneal epithelial cell adhesion and migration through modifying the organization and proteolytic processing of laminin 332 Laminin N-terminus α31 (LaNt α31) is a netrin-like protein generated by alternative splicing of the laminin α3 gene. While previously shown to regulate vascular permeability in vivo, its role in epith...

New publication from the Hamill Lab!

Laminin N-terminus α31 regulates corneal epithelial cell adhesion and migration through modifying the organization and proteolytic processing of laminin 332

journals.plos.org/plosone/arti...

If you are interested in basement membranes, this is for you...

I am very proud of this piece as it embodies what I really want my lab to do. Developing and using advanced (image) analysis methods to study complex biological phenomena.
This paper contains a lot of methodology, but even more biology. It is foundational for the work we are currently doing.

We are thrilled to share our new pre-print on the molecular anatomy of nuclear proteasome in human sperm cells! #In-cellcryo-ET + #SPA + #LM! @piotrkolata.bsky.social @a-dsantos.bsky.social, @tomdendooven.bsky.social!! doi.org/10.64898/202...

Mechanotransduction by nuclear envelope tension Mechanotransduction mediated by the tension in lipid membranes is a well-established paradigm. This has been studied largely in the context of the plasma membrane, but recent work shows that it app...

This review was a fun collaboration with
Pere Roca-Cusachs - just published in a journal! www.tandfonline.com/doi/full/10....

Come on, do it. You know you want to. ⬇️

And that’s a wrap for the @cbias.bsky.social napari workshop as well. Two days of learning, working collaboratively and finished off with a presentation from each of five project groups detailing the progress they made. Organised by Rocco D’Antuono, @giuliapaci.bsky.social and yours truly

The Actin regulator Mena promotes Wnt signalosome endocytosis and Wnt signalling Wnt signaling controls embryonic development and tissue maintenance. Endocytosis of Wnt-receptors is required for signalling, yet uptake mechanisms remain poorly understood. Here, we identify the acti...

Exciting new findings: Wnt-receptor endocytosis is required for canonical Wnt activation, yet uptake mechanisms has been controversial. We resolve this by showing that Wnt3a triggers rapid Clathrin- and Fast Endophilin-Mediated LRP6 endocytosis at low concentrations sufficient for Wnt activation.

Early bird registration: Save £100 - 21 January 2026! Dynamic Cell VI conference, Reading, UK, April 2026! Co-organised by
@bscb-official.bsky.social

and
@biochemsoc.bsky.social

with
@royalmicrosoc.bsky.social

and the Chinese Society for Cell Biology.
Register now:
bit.ly/Dynamic-Cell-VI

An exciting project to understand cellular ageing in health and disease.
Deadline for applications is 4th Dec.
www.findaphd.com/phds/project...

Pls see also our group websites:

TobiasZech: tzech6.wixsite.com/zechlab
• Chris Toseland: www.toseland-
lab.com