Intracellular GPCR modulators enable precision pharmacology - npj Drug Discovery npj Drug Discovery - Intracellular GPCR modulators enable precision pharmacology

Must read!
Intracellular GPCR modulators enable precision pharmacology
www.nature.com/articles/s44...

#TobRegSky #PedSky #MedSky #addictionsci #neuroskyence #neurosci #policysky #polisky #painresearch 🧪🛟

Amazing indeed! This method tracks single molecules escaping nanoscale traps to reveal size, shape, and conformational states in solution. Hats off to the authors for an outstanding advancement.

Insights on psychedelics: A systematic review of therapeutic effects Insight – a sudden change in understanding or perspective that feels true or reliable – is a common occurrence during psychedelic experiences, and oft…

The first paper from my PhD has been published!

Insights on Psychedelics: A Systematic Review of Therapeutic Effects
www.sciencedirect.com/science/arti...

Exciting news from our team here at Vilya! RFpeptides is an RFdiffusion-based DL pipeline for designing macrocyclic peptides. Exclusively licensed to Vilya🔥

It’s an exciting time to at the forefront of the macrocyclic peptide drug discovery space.

Preprint:

www.biorxiv.org/content/10.1...

Congratulations!

Congrats @tastelabhuji.bsky.social and team!

PGxDB: an interactive web-platform for pharmacogenomics research Abstract. Pharmacogenomics, the study of how an individual's genetic makeup influences their response to medications, is a rapidly evolving field with sign

Another day, another excellent database.

I’ve been an avid and grateful user of GPCRdb, GPCRmd, and other databases, all of which keep getting better. I’m excited to try this one!

academic.oup.com/nar/advance-...

This is amazing! @shervinnia.bsky.social resurrected our cryoEM-papers bot. At it's peak we had over 12k followers on Twitter, but the bot became defunct by a silly Musk policy (and it all went downhill from there).
If you want to keep up with #cryoEM papers, follow:
cryoempapers.bsky.social

Discovery of Potent Kappa Opioid Receptor Agonists Derived from Akuammicine Akuammicine (1), an alkaloid isolated from Picralima nitida, is an agonist of the kappa opioid receptor (κOR). To establish structure–activity relationships (SARs) for this structurally unique κOR lig...

Another paper from the Van Rijn and Riley labs on natural product-derived agonists for the kappa opioid receptors.

pubs.acs.org/doi/10.1021/...

I’m leaning toward the former interpretation as well.

Otherwise I’ll be out of a job soon 😂

The experimental IC50 I obtain in the morning are sometimes different from those I obtain in the afternoon.. deriving those from docking scores is beyond me.

It’s giving ChatGPT vibes

Hi Dr. Gati :) catch up soon?

I still find myself lost whenever references to star wars are made during presentations. But you make a good point. It’s definitely more challenging in papers.

Amazing idea. Would love to see it extended to presentations too!

Please add me too!

A first attempt to assemble GPCR aficionados here on 🦋 Let me know who I missed by replying below!

go.bsky.app/75ukb81

It feels so good to be back! #sci-twitter was good but I hope #sci-sky will be better!

#science #gpcr #drugdiscovery