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Posts by Alec Downie

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Three open questions in polygenic score portability Nature Communications - Genetic predictors of health outcomes often drop in accuracy when applied to people dissimilar to participants of large genetic studies. Here, the authors investigate the...

Our work on the generalizability of polygenic scores (PGS) from the @arbelharpak.bsky.social Lab is now officially out!

We examine the accuracy of PGS predictions at the individual level. We make 3 observations that expose gaps in our understanding of PGS “portability.”

rdcu.be/e0LAr

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2 months ago 41 19 3 1
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What happens *after* enemy release? In a new paper, we present 7 years of infection & immune trait dynamics in 16 lake populations of stickleback.
www.journals.uchicago.edu/doi/10.1086/...
This is definitely the longest-scale study I've done in my career, I'm very excited to see it out.
1/6

1 week ago 40 14 2 2
description from Huntington library:

"A lithograph printed on heavy paper. Satirical "death certificate" issued for the Southern Confederacy. Mourning border, each line in different typeface, with: Died, Near the South-Side Rail Road, / on Sunday, April 9th, 1865, / The Southern Confederacy, / Aged Four Years, / Conceived in Sin, Born in iniquity, Nurtured by Tyranny, Died of / a Chronic Attack of Punch. / Abraham Lincoln, Attending Physician. / U.S. Grant, Undertaker. / Jeff Davis, Chief Mourner. Below in smaller print an epitaph that ends with: And this one line shall grace your grave-- / Your death gave freedom to the slave."

https://hdl.huntington.org/digital/collection/p16003coll6/id/5033

description from Huntington library: "A lithograph printed on heavy paper. Satirical "death certificate" issued for the Southern Confederacy. Mourning border, each line in different typeface, with: Died, Near the South-Side Rail Road, / on Sunday, April 9th, 1865, / The Southern Confederacy, / Aged Four Years, / Conceived in Sin, Born in iniquity, Nurtured by Tyranny, Died of / a Chronic Attack of Punch. / Abraham Lincoln, Attending Physician. / U.S. Grant, Undertaker. / Jeff Davis, Chief Mourner. Below in smaller print an epitaph that ends with: And this one line shall grace your grave-- / Your death gave freedom to the slave." https://hdl.huntington.org/digital/collection/p16003coll6/id/5033

to all who celebrate...

1 year ago 4349 1300 55 123

EEB Scholars - run by our wonderful Princeton EEB graduate students, now open for applications: eeb.princeton.edu/graduate/eeb...

2 weeks ago 7 13 0 0
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Wild mice show large, robust T‑cell receptor repertoires that stay broad across age and sex, while older mice develop more dominant clones, likely from lifelong pathogen exposure. A fascinating look at how immunity adapts in natural environments.

vist.ly/4wxid

2 weeks ago 6 3 0 0

New preprint from the fantastic @sarah-dobson.bsky.social !!

Worried about assuming causality when estimating selection? Confused about knowing whether selection is hard or soft? We have the solution for you!

3 weeks ago 20 7 1 0
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Environmentally driven immune imprinting protects against allergy - Nature In a mouse model, environmental immunostimulation in early life led to cross-reactive adaptive immune memory and reduced type II immune responses to allergens, indicating a mechanistic relationship be...

#WildImmunology #allegy
www.nature.com/articles/s41...

1 month ago 3 1 0 0
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Excited to share the latest preprint from the lab "Fluctuating environments are sufficient to drive substantial variability in species abundance across locations" now up on arXiv arxiv.org/abs/2603.02403 🎉

1 month ago 3 2 1 0
Professorship in population genetics in the field of evolutionary anthropology and medicine (W2) Faculties & Facilities

Leipzig U and the MPI for Evolutionary Anthropology (MPI-EVA) have an open faculty position (W2) in evolutionary population genetics! This position is tenured and comes with generous core funding. We are eager to welcome a new colleague! Deadline March 11.
www.uni-leipzig.de/en/newsdetai...

1 month ago 60 98 0 0

Waking up in the dark, routinely, day after day, is incredibly, *incredibly* bad for you (people who work night shifts for years on end have health outcomes similar to moderate smokers). Under permanent DST, sunrise in Seattle would be after 8am for 3.5 months a year.

1 month ago 12 2 3 2
Call for Applications - Max Planck Postdoc Program, apply now!

Call for Applications - Max Planck Postdoc Program, apply now!

The Max Planck #PostdocProgram offers top emerging talents a range of attractive measures and opportunities. The current call for applications is open from March 1st until April 13th, 2026. Please share or consider applying! 🙏
www.mpg.de/en/max-planc... #careerinscience #sciencecareer

1 month ago 44 38 0 1
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Have you ever wondered 🤔... Does phenotypic variance respond to environmental perturbation? Does it have a genetic basis? Are mean and variance regulating loci exposed to different selection pressures? These and more questions are explored in our new preprint 🔥

www.biorxiv.org/content/10.6...

1 month ago 88 49 2 4
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Hiring for 3 positions: Research Assistant, Field Research Coordinator, and Postdoc I am looking to hire 3 people into my lab this year. I am still doing the paperwork to get the jobs officially posted but I want to send the word out and screen potential applications right away. R…

I am hiring a research assistant (vampire bats), a Panama fieldwork coordinator (vampire bats), and also considering postdoc apps (social behavior, any species): socialbat.org/2026/02/19/h...

2 months ago 73 103 4 7

Just over a week left to apply for this PhD project (unfortunately UK students only). If you're interested then please get in touch!

2 months ago 10 9 0 0
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When someone believes in you How the ARTEMIS mentoring programme connects African students and doctoral researchers with scientists of the Max Planck Society — and why mentoring means more than just offering professional advice

So happy to have been part of the ARTEMIS Programme last year! Check out this piece to see Imma Mungai and me, plus a brief overview of the programme.

The new call is open, if you’re a scientist at an MPI, it’s a lovely opportunity! 👇
tinyurl.com/2wcpvk7f

@maxplanck.de
tinyurl.com/4ampx26u

2 months ago 16 3 0 0
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🧪Before the day begins, meerkats share a unique ritual. After emerging from their burrows, they spend up to an hour "sunning" to warm up for the day. During this quiet time, they produce soft, tonal "sunning calls". Just standing, sunbathing, and calling. But why❓ #bioacoustics #meerkats #kalahari

2 months ago 102 25 6 3
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Postdoktor i parasiters populationsgenetik Zoologiska institutionen är en av de äldsta institutionerna vid Stockholms universitet och har en lång historia av grundläggande och tillämpad djurforskning, från leddjur till stora däggdjur. I

Looking for a postdoc to work with existing SNP data from parasites of guppies across Trinidad. How do river structure, host specialisation, and host behaviour structure parasite population genetic structure and evolutionary potential? Join me in Stockholm! Email me :D

su.varbi.com/what:job/job...

2 months ago 10 15 0 0
Systematic Literature Review figure of how genetic relatedness estimates are done in the wild.

Systematic Literature Review figure of how genetic relatedness estimates are done in the wild.

(1/2) The preprint of our perspective on genetic estimates of relatedness in animal populations is out! Big Congratulations to Annika!
doi.org/10.32942/X28...

A systematic review of 2,861 articles shows that, even in 2025, 75% of such studies use microsatellites. And most use only a few!

#PopGen

2 months ago 14 5 1 0

This guy had no illusions of what America had been but believed in what it could be.

2 months ago 16 7 0 0
GBE | Genome Shows no Recent Inbreeding in Near-Extinction Woolly Rhinoceros Sample Found in Ancient Wolf's Stomach

Autopsy of Tumat
The autopsy of the Tumat-1 wolf puppy, when a fragment of a woolly rhinoceros tissue was found in the stomach. Coauthors Sergey Fedorov and Mikkel Sinding are shown. Location: Vienna, Austria. Date: 2018. Photo credit: Mietje Germonpré.

GBE | Genome Shows no Recent Inbreeding in Near-Extinction Woolly Rhinoceros Sample Found in Ancient Wolf's Stomach Autopsy of Tumat The autopsy of the Tumat-1 wolf puppy, when a fragment of a woolly rhinoceros tissue was found in the stomach. Coauthors Sergey Fedorov and Mikkel Sinding are shown. Location: Vienna, Austria. Date: 2018. Photo credit: Mietje Germonpré.

Guðjónsdóttir, @jcchacond.bsky.social et al. sequenced the genome of a >14kya old woolly rhino from muscle found inside a permafrost-preserved wolf's stomach. Demographic inference suggests a rapid extinction for the woolly rhino.

🔗 doi.org/10.1093/gbe/evaf239

#genome #evolution #aDNA

3 months ago 19 7 1 1

🚨🧪Listening to animals at scale is hard. animal2vec does the listening for you, automatically finding and classifying animal calls in huge datasets. Plus: MeerKAT, a massive new meerkat vocalization dataset, now public. #bioacoustics
besjournals.onlinelibrary.wiley.com/share/99RWYS...

3 months ago 15 4 1 0
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Embryo selection company Herasight goes all in on eugenics ...

I wrote about the bizarre case of Herasight, the embryo selection company going all in on eugenics.

4 months ago 124 82 6 15
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Thank you so much @profjudiallen.bsky.social 🤩 Thanks also to #BSI2025 & session organizers including @kathelse.bsky.social 🤩 for a fabulous week of talks & lively discussions!! It was my first BSI but I’ll be back 🤓

4 months ago 5 2 0 0
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Architecture of the neutrophil compartment - Nature Mapping of the neutrophil compartment using single-cell transcriptional data from multiple physiological and patological states reveals its organizational architecture and how cell state dynamics and trajectories vary during health, inflammation and cancer.

Nature research paper: Architecture of the neutrophil compartment

go.nature.com/3KzY1CV

4 months ago 37 7 0 2

***Super cool-project alert***⚠️ Come work with @dirkmetzler.bsky.social and me in trying to understand how transcriptional noise evolves in a phylogenetic context 🧬 Deadline 15th Dec 2025 (Project funded by @dfg.de @gevol.bsky.social)

4 months ago 16 19 0 0
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Excited to introduce the Latent Layers Framework – now out in @behavecol.bsky.social – to help think through when and why network differences confound inference in (comparative) social network analysis! 🧵

tinyurl.com/3k3yahwy

4 months ago 41 19 1 2
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Interested in how life history may shape the gut microbiome of a wild mammal? Keen on getting to work with an iconic long-term study system in Scotland?

Check out this PhD opportunity with me, Josephine Pemberton and @gfalbery.bsky.social

Reach out to chat more!

www.findaphd.com/phds/project...

4 months ago 31 32 1 0
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The missing heritability question is now (mostly) answered Not with a bang but with a whimper

I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵

4 months ago 352 168 14 21

When different kinds of mobile genetic elements get together, they become even more powerful catalysts for microbial evolution! In this work we discovered a mechanism by which Insertion Sequences drive their spread across Plasmids, which helps explain this evolutionary potential!

4 months ago 3 2 1 0