Access in Action: How UCSF is Expanding Care to Support San Francisco’s Pediatric TB Response | Department of Pediatrics When a tuberculosis (TB) outbreak emerged at a San Francisco high school at the end of 2025, the scale was immediately clear. More than 1,200 students required evaluation, with high rates of infection...

With the ongoing #TB outbreak at an SF high school, we will leverage our expertise in child TB, with the @citc-tb.bsky.social and @ucsf-ctb.bsky.social. @ucsfchildrens.bsky.social is working closely with SF public health to support students and families.

pediatrics.ucsf.edu/news/access-...

30 Years of Progress in Pediatric Tuberculosis (and So Much More to Do) - Ann Loeffler, MD (4/17/25) YouTube video by UCSF Pediatrics

The current #tuberculosis #outbreak at a high school in SF is an important reminder of the advances and ongoing needs for child and adolescent TB; check out the recent @ucsfchildrens.bsky.social grand rounds on #childtb: youtu.be/RiOt70vekHI?...
#idsky #tbsky

#tbsky #idsky We modeled the use of child TB treatment decision algorithms - providing primary care facilities with diagnostics is lower cost than referring all to district facilities, but we need to still improve specificity and reduce treatment costs: journals.theunion.org/content/ijtl...

This Wed, @djaganath.bsky.social MD delivers the CPH seminar on TB biomarkers, and moving from discovery to practice. Join us! Oct 22 1-2 PT Via Zoom. @ucsfchildrens.bsky.social Register here: buff.ly/7OsMIyY

Adolescents may particularly be interested in digital adherence technologies (DATs) to support TB treatment. We performed the first analysis of DATs for adolescent TB, and found high uptake, higher treatment success and lower loss to follow up: www.ingentaconnect.com/content/iuat...

#tbsky

Computer-aided reading of chest radiographs for paediatric tuberculosis: current status and future directions Computer-aided detection (CAD) systems for automated reading of chest x-rays (CXRs) have been developed and approved for tuberculosis triage in adults but not in children. However, CXR is frequently t...

Although several AI algorithms can interpret chest x-rays for TB, we still do not have validated or approved CAD products for children. With @jaseddon.bsky.social and colleagues, we shared our thoughts on how to advance CAD for #pediatricTB:

www.thelancet.com/journals/lan...

#tbsky #idsky

Enjoyed working with the CA TB controllers association to develop a simple aid to guide #TBprevention in children, please check it out here and share: ctca.org/wp-content/u...

@citc-tb.bsky.social #tuberculosis #LTBI

Check out our new paper!

Plasma proteomics for biomarker discovery in childhood tuberculosis - Nature Communications In this work, through a comprehensive proteomics approach, the authors identified host plasma protein biosignatures that could distinguish tuberculosis (TB) disease in children.

In this work, the authors use #proteomics to identify plasma protein signatures as biomarkers of #tuberculosis disease in children

@afossati.bsky.social @djaganath.bsky.social @dlswaney.bsky.social

@ucsf-ctb.bsky.social @tb-innovation.bsky.social

Plasma proteomics for biomarker discovery in childhood tuberculosis - Nature Communications In this work, through a comprehensive proteomics approach, the authors identified host plasma protein biosignatures that could distinguish tuberculosis (TB) disease in children.

We need new biomarkers to improve TB diagnosis in children. In the COMBO study, we performed a comprehensive plasma proteomic analysis across 4 countries and found several protein signatures that met the WHO target accuracy for a TB screening test: www.nature.com/articles/s41...

#tbsky #idsky

Parallel use of low‐complexity automated nucleic acid amplification tests and lateral flow urine lipoarabinomannan assays to detect tuberculosis disease in adults and adolescents living with HIV - Bjerrum, S - 2025 | Cochrane Library Select your preferred language for Cochrane reviews and other content. Sections without translation will be in English.

Happy to be involved in these two TB diagnostic reviews
www.cochranelibrary.com/cdsr/doi/10....
www.cochranelibrary.com/cdsr/doi/10....
Great team lead by Stephanie Bjerrum, Laura Olbrich, Maunank Shah and @djaganath.bsky.social, with methodologists @yangbd.bsky.social and @tweis.bsky.social

@cdenki.bsky.social @ucsf-ctb.bsky.social @tb-innovation.bsky.social

Stool processing methods for Xpert Ultra testing in childhood tuberculosis: A prospective, multi-country accuracy study AbstractBackground. Centrifuge-free processing methods support stool Xpert Ultra testing for childhood tuberculosis (TB), but there are limited data on the

New Publication: We conducted a multi-country prospective comparison of 3 methods for stool processing for Xpert Ultra testing for childhood TB, and found they performed similarly and were usable and acceptable by lab workers: academic.oup.com/cid/advance-.... @cidjournal.bsky.social #tbsky #idsky

The recording is now available for the University of California, San Francisco Grand Rounds: Advances and Local Strategies in Pediatric TB presented by Dr. Ann Loeffler

youtu.be/RiOt70vekHI?...

#Tuberculosis #PediatricTB #GrandRounds #IDSky #TBSky

A prospective evaluation of a three-gene host response signature to classify tuberculosis severity in children AbstractBackground. Children with non-severe TB may benefit from short-course treatment, but point-of-care tools are needed to stratify disease severity. W

We need new ways to classify TB severity in children. Our new paper in @jpidsociety.bsky.social shows a 3 gene signature that only requires a finger prick could be helpful for children with confirmed TB: doi.org/10.1093/jpid...

#tuberculosis @ucsf-ctb.bsky.social @tb-innovation.bsky.social

Upcoming UCSF Grand Rounds: Advances and Local Strategies in Pediatric TB

Presented by Dr. Ann Loeffler

📅 April 17th
⌚ 12:00 pm Pacific Time

Watch on Zoom: ucsf.zoom.us/j/9748140490...

#PediatricTB #Tuberculosis #TBSky

The Accuracy of the Uganda National Tuberculosis and Leprosy Program diagnostic algorithm and the World Health Organisation treatment decision algorithms for childhood tuberculosis: A retrospective an... Author summary In this study, we assessed and compared the accuracy of the 2017 Uganda National TB and Leprosy Program (NTLP) algorithm with the 2022 World Health Organization (WHO) Treatment Decision...

Check out our new publication on the accuracy of TB treatment decision algorithms for childhood TB in Uganda: journals.plos.org/globalpublic...

#tbsky #tuberculosis #idsky

Tuberculosis Research at the National Institutes of Health - Saving Lives, Shrinking Costs, Fueling American Jobs and Innovation – Treatment Action Group This policy brief describes the crucial role NIH plays in supporting research on new products to prevent, diagnose, and cure TB. This research is especially important at a time when new forms of drug ...

#Tuberculosis Research at the National Institutes of Health – Saving Lives, Shrinking Costs, Fueling American Jobs and Innovation www.treatmentactiongroup.org/publication/... #NIH #TB #HIV

@treatmentactiongroup.org

Opinion | Musk Said No One Has Died Since Aid Was Cut. That Isn’t True. (Gift Article) A journey through the front lines of global poverty shows that when the world’s richest men slash aid for the world’s poorest children, the result is sickness, starvation and death.

Why should we help? I’ve heard many complex reasons, but ultimately because we can and should. #idsky #tuberculosis #hiv

Dozens of Clinical Trials Have Been Frozen in Response to Trump’s USAID Order The stop-work order on U.S.A.I.D.-funded research has left thousands of people with experimental drugs and devices in their bodies, with no access to monitoring or care.

Abandoned in the Middle of Clinical Trials, Because of a Trump Order

www.nytimes.com/2025/02/06/h...

We cannot let the amazing progress we have made be lost; #idsky #pedsky #tuberculosis

Here’s the link to the new HHS campaign to combat misinformation about vaccines, which are the greatest miracle of modern medicine (and vaccines are one of the few cost-saving health interventions we have). #IDSky www.hhs.gov/letsgetreal

Congrats to the TB-CHAMP and VQUIN teams on their landmark work to guide treatment of MDR-TB exposure. This also shows we can conduct parallel and coordinated child and adult studies to advance care for all.
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
#idsky #pedsidsky #tuberculosis