So very depressing

Incredible, Kait!!!

Very fun collaborating with the Russell lab on this one. Tireless efforts of Dr. Truc (Cloe) Losier to bring this across the finish line.

Excited to share our new autophagy resource here, a dataset directly contrasting kinase regulators of bulk or organelle-specific autophagy. Look at the results for your gene/organelle of interest or get ideas for your own parallel screen. #autophagy #CRISPR #functionalgenomics

rupress.org/jcb/article/...

Losier, Russell et al. @uottawa.ca identify distinct kinase signaling pathways that differentially regulate bulk and selective #autophagy. Using kinome-wide #CRISPR screening, they reveal both shared and pathway-specific regulators rupress.org/jcb/article/...

Go get it!

Campus polls open at universities and colleges across Canada Elections Canada spokesperson Serge Fleyfel said the on-campus polling stations are part of the agency’s efforts to make casting a ballot easier for younger voters

Good morning #university students in Canada!

📢 Spread the word; you can #VoteOnCampus April 13-16.

#VoteScience🇨🇦 #VoterRecherche #VotonsRecherche #ResearchersVote

#Elxn45

🎁
www.theglobeandmail.com/gift/c231c7b...

Thrilled to see our work published in its final form @Mol. Neurodegeneration. Outstanding work by @terryrsuk.bsky.social and colleagues. Please check-out the "skytorial" below. As always, happy to share reagents (plasmids are being put on @addgene.bsky.social ), mice and other data; just reach out!

Looking for alternative non-US suppliers of lab reagents too. Would be great if someone had a list to share.

To me, the worrying part about the push for more research on vaccines and autism isn’t that it’s a waste of money, it’s that those pushing for more research are also interested in seeing a specific result. And if they start messing w the process of science, that would send us down a really dark path

It’s pretty easy to “apply” for a PhD in Canada, and a little different from most US places, just send a cover letter, CV and undergrad transcript to a PI you’d like to work with. Put some effort into it, make sure you convey what you’re applying for and why.

With the craziness going on in the south, I am opening up a few postdoc positions in my lab. Contact me if interested. Those with experience in ethnic-racial marginalized families, peer relationships, EEG, and ILD are especially welcome! Please circulate, thx!!

A topographical atlas of α-synuclein dosage and cell type-specific expression in adult mouse brain and peripheral organs - npj Parkinson's Disease npj Parkinson's Disease - A topographical atlas of α-synuclein dosage and cell type-specific expression in adult mouse brain and peripheral organs

Ab185966 has worked nicely for us.

www.nature.com/articles/s41...

Did you ever think about how much time you spend *judging* as a scientist? Judging papers, research proposals, other scientists...
This onslaught of judging duties hit me hard as a new professor & I've written about the need to explicitly decide one's judging criteria here 👇

🎄PinkyCaMP- our christmas gift to you! 🎁: We are excited to present PinkyCaMP, the first mScarlet based calcium sensor with:
✨exceptional, brightness
✨phototability
✨and optogenetic compatability.
Check out our new preprint:
www.biorxiv.org/content/10.1...

In case any of my fellow creatives also needed this reminder:

The preprint battle in neuroscience has gradually been won. I think the next step will be more dramatic -- a collapse in peer review resources to service each paper.

Alpha-synuclein knockout impairs melanoma development and alters DNA damage repair in the TG3 mouse model in a sex-dependent manner www.biorxiv.org/content/10.1101/2024.12....

I will have space in my lab to supervise a new Ph.D. student and/or a postdoc to work on projects focussing on the role of the immune system in Parkinson's disease. Please share with potentially interested candidates.

👆🏻was really helpful for us! cFos was a great positive control (thanks to @weihsiah.bsky.social’s advice)

The image shows monthly traffic to protocols.io from Twitter since March, 2024. The trend is a rapid decrease (and March 2024 was already just a fraction of the traffic from Twitter years ago).

Twitter used to be the second-highest source of traffic to protocols.io as researchers shared their public methods (highest was Google). Today, 0.1% of our monthly traffic is from Twitter.

I'm hopeful for the growth of the research community on Bluesky & sad about the senseless demise of Twitter.

We are starting a search for senior and mid career researchers candidates for the Canada Excellence Research Chair Program. We have amazing infrastructure for research including state of the art microscopy (STED, lightsheet etc), 🐁 behavior and MRI facilities (new 15.2T for 🐁 ) mouse-trap.org

Download our database of 492 (!) funding opportunities for EARLY-CAREER FACULTY AND RESEARCHERS.

For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).

Download freely here: research.jhu.edu/rdt/funding-...

You look like you are just getting warmed up, Dennis. Keep it up! When in doubt, hookup with a fellow runner and walk them through Colts preseason chit chat, the miles will fly by.

Lookin' strong! Show D Proctor who's boss!

Way to go Eve! My wonderful colleague, friend and mentor Eve Marder just won the National Medal of Science!
www.c-span.org/video/?53134...