✨ Happy to share that our paper, “BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants,” is now online in Cell.
Congratulations to everyone involved, a moment to celebrate! 🎉 🥂
#ErasmusMC, #Cell, #FunctionalGenomics #AI ##NonCodingDNA #Rotterdam
Onderzoekers van Erasmus MC gebruiken kunstmatige intelligentie om verborgen schakelaars te zoeken in het DNA. Die aanpak kan mensen met een zeldzame genetische aandoening alsnog een diagnose bezorgen. amazingerasmusmc.nl/genetica/ai-...
I miss when the biggest controversy about mRNA was whether it correlated with protein or not.
In 2024 NIH grant awards supported 407,782 jobs and $94.58 billion in new economic activity nationwide, the largest figure in the history of the report. www.forbes.com/sites/michae...
Roche SBX deep dive into the real specs. What is hidden behind the numbers presented by Roche?
open.substack.com/pub/albertvi...
Thank you for sharing! Very interesting development
A Direct Hit, by @holdenthorp.bsky.social @science.org
www.science.org/doi/full/10....
"This is a moment to unite."
Gene editing technology began by people studying salt marshes. Ozempic began by folks studying the venom of Gila Monsters. Support for basic science has empowered us to understand our world. Tethering it to applications health has transformed and saved countless lives.
The craziness is back …😢…
Gulf of America 😂
January 20, Independence Day 😂
State of emergency, but this time Mexico will not pay for it 😂
I will it was just a stand up comedian performing
The Institut Pasteur has decided to leave X (formerly Twitter) to join BlueSky! 🦋
The Institut Pasteur made this decision due to several serious issues observed on the X platform since its acquisition. Join us here to continue advocating for science. www.pasteur.fr/en/home/pres...
It’s official 🎉 I am excited to share that I will start my lab this spring at the Max Planck Institute for Immunobiology and Epigenetics @mpi-ie.bsky.social in beautiful Freiburg 🤩🗻☀️ I am looking forward to new collaborations and working with the fantastic community in Freiburg & its surroundings!
Congratulations Juliane!👏
I am very happy to see this 😍😍
Good to see how people are helpful
The international Curie « Noncoding Genome » course has been revamped! 👉 Dark genome in cell plasticity and heterogeneity. A session on TEs #TEsky with M.E. Torres Padilla, D.Trono and @aktast.bsky.social. Master, PhD and postdoc fellows, a week in Paris during the Spring?
Apply before Feb 15th
📌
Thank you Max!
Yes, I am doing well! I hope all is well on your side!
This work would not have been possible without the dedication my team and collaborators. A heartfelt Thank you and congratulations to everyone involved!
#hematopoiesis #AML #science #CRISPR #epigenomics
5) Clinical Relevance: XACT expression in a subset of AML patients, combined with its exclusive expression in myeloid progenitors, points to its potential as a marker for AML subtypes.
4)Functional Insights: CRISPR-based XACT perturbation, along with epigenomic and transcriptomic studies, reveals XACT’s crucial role in regulating erythroid progenitor self-renewal and differentiation by modulating transcription
3.1) Interestingly, this new XACT transcript that we discovered in the erythroleukemic K562 cell line and is also expressed in a subset of acute myeloid leukemia (AML) patients.
3) Expression during differentiation and cancer: During hematopoiesis, XACT exhibits a distinct expression pattern specific to myeloid progenitors.
2) This new XACT transcript is present on both the inactive (Xi) and active (Xa) X-chromosomes, coexisting with XIST on the Xi. However, it does not affect XIST expression or (re)activate X-linked genes silenced by the X-chromosome inactivation mechanism.
Key Highlights:
1) A novel discovery: We discovered a new XACT lncRNA transcript expressed in normal and cancerous somatic cells of both sexes.
Starting the new year with exciting research output from my group!
I'm excited to share our latest research on a novel XACT lncRNA transcript discovered by my group, which provides new insights into its role in both normal and cancerous somatic cells.
#ErasmusMC #lncRNA #XACT