De novo design of potent CRISPR–Cas13 inhibitors - Nature Chemical Biology Taveneau et al. leverage artificial-intelligence-driven protein design to create inhibitors that control RNA-targeting enzymes in cells, revealing a strategy to rapidly design off-switches for RNA-edi...

Finally out 🎉
New paper in Nature Chemical Biology!

Using RF-diffusion, we designed protein inhibitors that bind the CRISPR Cas13a active site, something very hard to find in nature.

Thanks to everyone involved for the hard work! 👏

www.nature.com/articles/s41...

Big news! 🎉 The CRISPR Down Under 2026 speaker line-up is out.

Join us in Melbourne (24–25 Mar) for two days of exciting CRISPR science, great talks & great people !

Early-bird & abstracts close 30 Jan !

🔗 crispr.org.au

CRISPR Down Under Melbourne Connect, 700 Swanston St, Carlton VIC 3053 Tuesday 24th - Wednesday 25th March, 2026

CRISPR Down Under 2026 is here!

📍 Melbourne | 📅 Mar 24–25 2026

Early-bird ends Jan 30!
Register & Abstracts : crispr.org.au

Join us for cutting-edge CRISPR research!
#CRISPR #MelbourneEvents

And of course, big shout-out to the AIPDP team, especially @danielrfox.bsky.social and @pansapiens.bsky.social !

Huge thanks to @twistbioscience.com and @monashuniversity.bsky.social for their support!

Big milestone for the AI Protein Design Program last November: our first AI binder design workshop! Proud of the team and grateful to @kmichie.bsky.social for her amazing talk. This is just the beginning… excited for what’s next!

#AI #ProteinDesign #AIPDP

Really happy to have been part of this journey and to co-author this piece with @danielrfox.bsky.social , Janik Clement, @rhyswg.bsky.social and @knottrna.bsky.social !

Code to complex: AI-driven de novo binder design In this review, Fox et al. discuss how artificial intelligence has transformed our ability to design new-to-nature proteins that bind target proteins with high affinity and specificity. The authors de...

Excited to share our new review on AI-driven protein design - from its origins to today’s breakthroughs, methods, potential, and challenges ahead !

www.cell.com/structure/fu...

Thrilled to be part of this great @ausbiocommons.bsky.social initiative : a webinar serie on AI-based binder design :)

I’ll be sharing a case study on using deep learning to design programmable CRISPR inhibitors

12 August 12pm AEST, love to see you there ! www.biocommons.org.au/events/prote...

🦠🧍‍♀️From bacterial to human immunity.

We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social

www.science.org/doi/10.1126/...

Big news! 📢CCeMMP is holding the 2nd 'Bench to Art' Exhibition to showcase the artistic flair of structural biology. Share your creations to be displayed in a virtual gallery during National Science Week & for a chance to win cash prizes 💰! More info: ccemmp.org/events/arc-c...

#CryoEM
#Membranes

WEBINAR SERIES: Leveraging deep learning to design custom protein-binding proteins — Australian BioCommons Be inspired by case studies that show you how deep learning methods are speeding up the process of designing proteins with desirable biophysical properties. More information Register

ASBC and Biocommons are building opportunities for researchers to discuss and explore protein design tech. First up is @rhyswg.bsky.social. Excited for this!

Proud to share some of the work from my PhD is now out in Nature Communications! Very grateful to all coauthors who helped make this happen, especially my supervisors @rhyswg.bsky.social and @knottrna.bsky.social for their support. 🩸 🦠 🔬

Folddisco finds similar (dis)continuous 3D motifs in large protein structure databases. Its efficient index enables fast uncharacterized active site annotation, protein conformational state analysis and PPI interface comparison. 1/9🧶🧬
📄 www.biorxiv.org/content/10.1...
🌐 search.foldseek.com/folddisco

See the Milky Way dazzle during a lunar eclipse — May’s best science images The month’s sharpest science shots, selected by Nature’s photo team.

An epic sky, singing cicadas, and a solar explosion. See this and more in this month's best science shots

https://go.nature.com/3ZaM0rD

We're on the cover of @science.org this week. Awesome work by @florentwaltz.bsky.social. #CryoET is reaching crazy resolutions inside cells, and this is just the beginning. Fantastic interpretation of the proton motive force by @verenaresch.bsky.social. Always a pleasure making #SciArt with you!🧪🧶🧬🌾

"Nous devons attaquer honnêtement et agressivement les universités de ce pays." Ces mots sont ceux du vice-président américain J.D. Vance en 2025. Claire Mathieu, mathématicienne à l’ENS et membre de l’Académie des sciences, alerte : la science et la quête de vérité sont menacées aux États-Unis.

Eukaryotes' closest relatives are internally simple syntrophic archaea Eukaryotes are theorized to have originated from an archaeal phylum Promethearchaeota (formerly 'Asgard' archaea)1,2. The first cultured representatives revealed valuable insight3,4 but are distantly ...

New isolates from eukaryote's closest archaeal relative: ‘Hodarchaeales’!! Syntrophic microaerotolerant peptide-degrading anaerobic archaea w/ simple cell structure & protrusions. Features conserved across the phylum provide new insight into our ancestor’s biology!
www.biorxiv.org/content/10.1...

It was a fantastic talk, thank you !

In love with this movie !

Cas activity assay. 3 strongest inhibitors characterised. Mimic RNAs. Xtallised one. Two others wouldn't xtallise, CD agrees with prediction; also checked folding/stability. Nice candidates for regulation of Cas. Functional in bacteria. Rescue phage infection as designed. As a crispr off switch - 8 weeks from AI design to targeted inhibitor.

Session 9 Cyntia Taveneau: De novo design of crispr-cas inhibitors. CRISPR system degrades DNA from phage; phage escape with antiCRISPR. Can we design them?? AIcrs designed to block active site of Cas13. #RFdiffusion Scoring top 96. Expr and purify. Biolayer interferometry. #LorneProteins2025

"On est entré dans un nouveau monde" : comment l'IA révolutionne la microbiologie En permettant de prédire la structure d'une protéine à partir d'une séquence d'ADN, Alphafold, le système mis au point par Google DeepMind, a ouvert en grand le champ des possibles pour les chercheurs...

Petit reportage de France Inter sur notre utilisation de l'IA au labo:
- Combiner prédictions informatiques et validations expérimentales
- Un nouveau monde à explorer
- Des utilisateur.rice.s divers doivent s'approprier l'IA pour inventer des usages divers.
www.radiofrance.fr/franceinter/...

Scaling data analyses in cellular cryoET using comprehensive segmentation

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Scaling data analyses in cellular cryoET using comprehensive segmentation [new]
Comprehensive segmentation of cryoET data enables ontology-based voxel ID, used for context-aware particle picking and faster template matching.

Dynamic PRC1–CBX8 stabilizes a porous structure of chromatin condensates - Nature Structural & Molecular Biology Here the authors show that a gene-inactivating protein complex packs inactive genes into a dynamic and accessible structure. The study challenges the traditional views that restricted accessibility an...

We used cryoET and biophysical approaches in vitro together with molecular biology in differentiated cells to show that chromatin compacted by PRC1-CBX8 is porous and accessible while PRC1 is dynamic in it. 🧪🧬 #cryoET #Epigenetics #Polycomb www.nature.com/articles/s41...

After a decade in the oven🧑‍🍳, we’re happy to finally share our preprint on the in situ architecture of the ciliary base.

📜 https://dir.lat/41qAY4

We used #CryoET to resolve transition zone structures and reveal the stepwise assembly of IFT...

Towards community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii In situ cryo-electron tomography (cryo-ET) has emerged as the method of choice to investigate structures of biomolecules in their native context. However, challenges remain in the efficient production...

More than 1'800 tomograms available for the community. Towards visual proteomics using our favorite organism Chlamy!

Check out the preprint: www.biorxiv.org/content/10.1...

Find it on EMPIAR (11830) and fully annotated on the CZI data portal: cryoetdataportal.czscience.com

#TeamTomo

Do you want to work at the interface of molecular simulations, structural biology experiments and #AI? Come to Paris for a PhD at @pasteur.fr 1 PhD position is available in our lab funded by ERC_Research. Please repost!! #compchem #compbio Info 👇 research.pasteur.fr/b/15Hr

Lorne Protein Meeting poster

Interactive Program now live for the Lorne Protein Conference 2025! Merry Christmas and Happy New Year!
www.lorneproteins.org

A postdoctoral position is available in our team to study the type VI secretion system.
Biochemistry, X-ray cryst and some cryoEM with @fronzeslab.bsky.social team
Reposts appreciated 😊