Congrats to Jobert, Anna-Leigh, and Kai on showing how #BDNF amplifies #transcription, coordinates #RNA dynamics, and spatially regulates the #phosphoproteome.
Beautiful cover art too!
@jamessleigh.bsky.social @frattalab.bsky.social @uclqsion.bsky.social
Recently published work lead by the very talented @dvillarroelc.bsky.social. Lots of work has gone in to this and I have enjoyed seeing this story develop over the years. Congrats to all! @jamessleigh.bsky.social @joburrito.bsky.social @frattalab.bsky.social @uclqsion.bsky.social #axonaltransport
Do all #NTFs regulate #MotorNeuron axonal transport in vivo?
Our new preprint shows they do not.
#BDNF enhances (shorturl.at/siwFi), #CNTF slows, and #HGF, #NRTN & #proBDNF show no effect.
#AxonalTransport regulation is selective, not universal.
@jamessleigh.bsky.social @uclqsion.bsky.social
A wonderful collaboration. Congratulations to @nicolbirsa.bsky.social & @beccasimkin.bsky.social and all the co-authors #axonaltransport #FUS #MND #ALS #NMJ
Our new paper in Neurobiology of Aging showing that processivity and BDNF-dependent modulation of #AxonalTransport are impaired in aged mice:
www.sciencedirect.com/science/arti...
@dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social @uclqsion.bsky.social #aging
🚨New
@biorxivpreprint.bsky.social
collab b/w Fisher, Cunningham, Gilthorpe &
Schiavo Labs. @mrcharwell.bsky.social @uclqsion.bsky.social @umeauniversitet.bsky.social
Metabolic alterations in the absence of a detectable neuromuscular phenotype in novel humanised SOD1A4V mice.
t.co/u01CG6ctTS
In our latest pre-print, we show that processivity and BDNF-dependent modulation of #AxonalTransport are impaired in aged mice:
www.biorxiv.org/content/10.1...
Well done team! @dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social et al.
@uclqsion.bsky.social #aging
Congratulations Sean!
A little about me! 🦋 With help from Scholar Goggler scholargoggler.com
I will try to take on the challenge to highlight some of the cool bioimage analysis tools we use all the time. #BioimageTooloftheDay
I will start with ijp-LaRoMe, a very nifty Fiji plugin that I use all the time to convert ROI to label images and vice versa
github.com/BIOP/ijp-LaR...
Can you please add me too! Many thanks
Looking forward to AXON2025 - mark your calendars
Thanks for sharing!