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Posts by Freddy E Escorcia, MD/PhD

🙏 Grateful to all the co-authors for a fun and productive collaboration and to @nih for support!

Stay tuned as the final few papers from the lab make it throught he publication process.

Link: jnm.snmjournals.org/...
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Importantly, the kidney retention was MUCH more favorable than our prior nanobody immunoPET efforts, suggesting a possible approach for antibody-fragment based #radiopharmaceuticals therapy.


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After screening several clones, we locked in on one and engineered an immunoPET agent with good tumor:background in subq and orthotopic models of #HCC.
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Link to paper: jnm.snmjournals.org/...
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🚨New pub just dropped🚨

This effort was led by former postbac Divya Nambiar, and scientist Thomas Esparza, and brought to the finishline by Orit Jacobson at the NIH!

We identified an #HCC-selective target CD147/BSG, and engineered a novel nanobody-based immunoPET agent.
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National Academies Eric and Wendy Schmidt Awards for Excellence in Science Communications The National Academies are accepting submissions to an annual award program that aims to recognize and develop excellence in science communication by research scientists, science journalists, and scie...

The @nationalacademies.org Awards for Excellence in #scicomm have honored some of the best thinkers & creatives I know, like @chanda.blacksky.app @neillewisjr.bsky.social @cbo.bsky.social

Top award: $40,000.
Deadline: April 3.
Explore & apply
www.nationalacademies.org/programs/NAE...

1 month ago 78 44 0 2

Beautifully written essay…

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Year 2, Week 12 Mar 14-20, 2026 - equinox

Each Friday night, I write a briefing on what happened in US science & higher ed. 🧪 

Mar 20 (Year 2, Week 12)
- major ruling! ACIP & vaccine schedule illegitimate
- NIH funds finally(?) “flowing” & what that actually means - NSF still hostage to OMB

& so much more

buttondown.com/liminalcreat...

1 month ago 29 17 1 0
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Call for Letters of Inquiry: Exemplary Pathways to STEM Graduate Education | Alfred P. Sloan Foundation Our mission is to make the world a better place through the advancement of scientific knowledge.

New @sloanfoundation.bsky.social grants: Exemplary Pathways to STEM Graduate Education.

Up to $500,000 for orgs focused on helping remove obstacles for undergraduates who want to pursue advanced STEM degrees.

Deadline is June 1. Please share & apply if this is you! sloan.org/programs/hig...

1 month ago 62 55 0 1

This is soooo cool!

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Whoa!🤯

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This is kinda bonkers.

In addition, 20 amino acids were found on Ryugu, along with uracil and vitamin B3. These have been found in other instances, but since the samples from Ryugu were collected directly from the asteroid and delivered in sealed capsules, contamination on Earth could be ruled out.

1 month ago 208 98 8 7

I don't think most people would say "it was fine before." Getting a sub 10%ile grant is really hard. But having 5th %iles go unfunded just feels bewildering. It's not that they are objectively better than the 10%iles, but getting 5 requires enormous luck and even that is now not good enough.

1 month ago 10 3 2 0
A line graph showing NSF grant awards made through 2/27/26 for fiscal year 2026 compared with grant awards for fiscal years 2021-2025.

A line graph showing NSF grant awards made through 2/27/26 for fiscal year 2026 compared with grant awards for fiscal years 2021-2025.

NSF Update (Awards through 2/27/26)

Directorates to follow

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Now this is a goddamn paper

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Screening, sorting, and the feedback cycles that imperil peer review The process of peer review is vital to contemporary science, but is also under enormous strain. This study uses mathematical models to dissect the threats to the long-term viability of peer review, su...

1. Kevin Gross and I have a new paper out today PLOS Biology.

We used economic models based around screening games and the market for unpaid labor to highlight a meltdown cycle threatening peer review.

1 month ago 324 132 8 17

My quote of the day

Science is fun. Science is curiosity. We all have natural curiosity. Science is a process of investigating. It's posing questions and coming up with a method. It's delving in.

Sally Ride

2 months ago 64 10 3 2

At this point, I'll pay people to stop writing Alzheimer's grants.

2 months ago 2 1 0 0

My quote of the day

Ignorance more frequently begets confidence than does knowledge: it is those who know little, and not those who know much, who so positively assert that this or that problem will never be solved by science.

Charles Darwin

2 months ago 83 34 3 1

💔

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My quote of the day

All of us might wish at times that we lived in a more tranquil world, but we don't. And if our times are difficult and perplexing, so are they challenging and filled with opportunity.

Robert F. Kennedy

2 months ago 39 7 4 1
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🔔HIRI has opened a new call to recruit Group Leaders. If you are interested in opening an RNA Biology and Infection lab, join us! Deadline: February 15. More info here 👇

2 months ago 11 11 0 1
Video

AOC: "Early reports are that he was an ICU nurse at the Mpls VA. So we are talking about Donald Trump accusing a VA ICU as being a terrorist against the United States. A man who was treating service members to our country ... his final act on early was helping a woman pushed to the ground."

2 months ago 5431 1498 76 57

He wasn't a domestic terrorist. A domestic terrorist was the Oklahoma City bomber. This was a VA nurse looking out for his neighbors.

2 months ago 2309 491 62 15
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“.. He cared about people deeply ..,” said Michael Pretti, Alex’s father. “He thought it was terrible, you know, kidnapping children, just grabbing people off the street. He cared about those people, and he knew it was wrong ..”

@washingtonpost.com
www.washingtonpost.com/national/202...

2 months ago 7108 2431 127 104
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US science after a year of Trump: what has been lost and what remains A series of graphics reveals how the Trump administration has sought historic cuts to science and the research workforce.

Trump has been in office for one year. We at @nature.com did a deep dive looking at the administration's disruption of science in numbers.

Take a look—the numbers are staggering. By me, @dangaristo.bsky.social, Jeff Tollefson, @kimay.bsky.social, & help from @noamross.net @scott-delaney.bsky.social

3 months ago 504 317 10 30

This is how we first teach chirality to our undergrads !

3 months ago 117 30 4 2

I worked 16 years in the Office of the Secretary at the Department of Homeland Security, including as the Intel & Ops briefer to the Secretary, the Department's Congressional Reports Officer, & as the Exec Sec for OGC. If I can be useful to your law firm, NGO, or Cong. office, please let me know.

3 months ago 18 9 1 0

The data show that when you let more women and racial/ethnic minorities into your academic society they tend to be overrepresented doing the service work of your society. Isn’t that interesting? #ACNP2026

3 months ago 42 8 2 0

It’s a fun read. Did you read The Martian? Sooo good!

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