Open licenses power discovery!
Melissa Harrison shares a @pfamdb.bsky.social use case:
Pfam uses AI to extract information about known protein domains
This helps predict protein function & identify potential drug targets! 💊
#ChooseOpenWebinar for live updates 💡
#MedLib #PhDsky #OpenAccess
Poster A-098: Pfam database in 2025 – towards expanding protein families coverage Nicole Morveli Flores Session A: 21/07/2025 10:00 – 11:20 and 16:00 – 16:40 BST Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI
InterProScan 6: a modern large-scale protein function annotation pipeline Matthias Blum 21/07/2025 14:20 Room 03A Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI
Poster A-205: Carbohydrate active enzymes in Pectobacteriaceae: coevolving enzyme sets and host adaptation Emma Hobbs Session A: 21/07/2025 10:00 – 11:20 and 16:00 – 16:40 BST Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI
Accelerating protein family classification in InterPro with AI innovations Matthias Blum 22/07/2025 16:40 Room 12 Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI
🧬 The InterPro/Pfam team will be presenting at #ISMB2025 next week in Liverpool!
🎤 Multiple talks & 📊 posters on protein analysis & classification
💻🧪
The InterPro/Pfam team members attending ISMB/ECCB 2025: Alex Bateman, Emma Hobbs, Matthias Blum, Nicole Morvelli, Antonina Andreeva Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI
🧬 The InterPro/Pfam team will be presenting at #ISMB2025 next week in Liverpool!
Join us July 20-24 at the world's largest #bioinformatics conference!
#ISMBECCB2025 #ProteinAnalysis #ComputationalBiology
💻🧪
Come chat to us at @jobim2025.bsky.social!
Promotional slide for a webinar titled "What happens when you choose closed? What Creative Commons licenses mean for research and AI." The slide features photos and names of five speakers: Melissa Harrison (Europe PMC / EMBL-EBI), Katherine Hughes (EMBL), Taylor Campbell (Creative Commons), Monica Granados (Creative Commons), and Kat Walsh (Creative Commons). Logos for Europe PMC, Creative Commons, and EMBL are shown at the bottom. The background is green with white text.
Can AI train on my openly licensed research? Do I retain copyright if I choose a CC BY license? Why can’t I reuse a figure from my own paper?
Get the answers in a webinar with Creative Commons, #EuropePMC & EMBL
🗓️ 9 Jul
⏰ 15:00 UTC
🔗 embl-org.zoom.us/webinar/regi...
#OpenScience #AcademicSky 🧪
Pfam 37.4 318 new families 4 new clans
Content Over 24,736 entries describing protein families, domains and repeats.
🚀 HUGE NEWS: Pfam 37.4 is LIVE!
318 brand-new protein families + 4 new clans! 🧬
Total collection now: 24,736 entries! 📈
Get exploring via InterPro website, API & Pfam FTP!
💻🧪
InterPro 106.0 19th June 2025
Databases updates: Pfam 37.4
New entries: 683 new entries with: 613 Pfam 78 NCBIfam 30 CDD 4 PANTHER ...
🚀 InterPro 106.0 is now live!
✨ Updated to Pfam 37.4
✨ 683 new entries added
✨ Enhanced protein classification coverage
Explore the latest annotations and discover new protein insights.
Explore it now: interpro.ebi.ac.uk 💻🧪🧬
#Bioinformatics #ProteinScience #Pfam #EMBLEBI
What’s new in the redesigned PDBe entry pages?
🧪 Cleaner layout
🧪 Interactive 3D viewers
🧪 Contextual annotations
🧪 Easier navigation
See for yourself:
wwwdev.ebi.ac.uk/pdbe/entry/p...
#PDBeBeta #Bioinformatics #Biochemistry #Science
🧬 MAJOR UPDATE: InterPro-N matches now available in InterPro!
1.8 billion AI-driven protein annotations developed with Google DeepMind are now live.
✨ Look for the sparkles icon to identify them
📊 Options menu lets you view: InterPro only | InterPro-N-only | Stacked
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TED domains alongside InterPro annotations for UniProt P05067
🔍 NEW: TED domains in InterPro 105.0!
For the first time, see AlphaFold-derived structural domains directly alongside InterPro annotations in one powerful visualisation. Bridging the sequence-structure divide in protein analysis. 💻🧪
Explore now: www.ebi.ac.uk/interpro/pro...
InterPro 105.0: AI for protein classification InterPro 105.0 is now live. This AI-driven update makes it easier than ever to explore the protein universe
📝 Check out our new blog post highlighting the groundbreaking features in InterPro 105.0!
Learn how InterPro-N, TED domains and viral protein structures are transforming protein classification: ebi.ac.uk/about/news/u...
🔥 Pfam 37.3 just dropped! 🚀
353 incredible new protein families + 7 new clans! 🧬✨
Revolutionise your research NOW via @interprodb.bsky.social website, API & Pfam FTP!
InterPro 105.0 24th April 2025
Databases updates Pfam 37.3 PROSITE patterns 2025_01 PROSITE profiles 2025_01 HAMAP 2025_01
New entries 342 new entries with: 318 Pfam 40 NCBIfam 12 Prosite profiles 6 PANTHER 5 CDD
New features InterPro-N annotations BFVD structure predictions Simplified structure pages
📢InterPro release 105.0 is live!
✨Update to Pfam 37.3, PROSITE patterns 2025_01
PROSITE profiles 2025_01 and HAMAP 2025_01
✨342 new entries
✨Addition of InterPro-N annotations
✨Addition of BFVD structure predictions from @martinsteinegger.bsky.social's lab
Have a look: ebi.ac.uk/interpro/htt...
💻🧪🆕
Want to use the InterPro API but not sure how to start? Join this upcoming workshop, where @typhainepl.bsky.social will guide you through the fundamentals and practical applications. Discover how to integrate this powerful tool into your workflow! Register now to secure your spot. 💻🧪
InterPro 104.0 6th February 2025
Databases udpates: Pfam 37.2, NCBIfam 17.0, CDD 3.21
661 new entries, containing: 663 Pfam 5 NCBIfam 5 PANTHER 9 CDD
New features: Redesigned protein viewer for sequence searches Wikipedia articles for Pfam clans Addition of PTM from the PRIDE database
🔈InterPro release 104.0 is live!
✨Update to Pfam 37.2, NCBIfam 17.0, CDD 3.21.
✨661 new entries, including 682 signatures from the Pfam (663), NCBIfam (5), PANTHER (5), CDD (9) databases. Have a look: ebi.ac.uk/interpro/ 💻🧪
Pfam 37.2: 302 new families and 18 new clans
Pfam 37.2 is out 🎉It contains 302 new families and 18 new clans You can have a look at them in InterPro: ebi.ac.uk/interpro/ent... or download the release from the Pfam ftp: ftp.ebi.ac.uk/pub/database...
InterPro website (home of Pfam) Help page
🔍 Lost in Pfam data? Our redesigned Help page has you covered! From quick answers to deep dives into protein families, find exactly what you need at www.ebi.ac.uk/interpro/help/ 💻🧪
Protein structure prediction from the AlphaFold Database
Prediction confidence scores help #AlphaFold users gauge the reliability of protein structure predictions. 🖥️🧬
But things get more challenging for protein families.
A new method helps improve low confidence predictions within protein families.
academic.oup.com/bioinformati...
Example of Profile HMM page for Pfam PF22971. It contains HMM data and Profile HMM logo
🆕The member database signature pages have undergone a thoughtful reorganisation to improve information accessibility.
1) Curation data are now in Overview
2) HMM information and logo are now in Profile HMM
Have a look: www.ebi.ac.uk/interpro/ent...
Cancer genomics and transcriptomics. Virtual. Closes 9 February. Introduction to metabolomics analysis. Hinxton. Closes 2 Feburary. Data science for life scientists. Hinxton. Closes 2 March. Data visualisation for biology. Hinxton. Closes 9 March. Systems biology: from large datasets to biological insight. Hinxton. Closes 16 March.
Welcome to 2025 🎉 We are running a number of exciting courses this year, so join us to boost your #bioinformatics, #datascience and #omics skills!
These courses are currently open for applications - find out more: www.ebi.ac.uk/training/liv...
💻🧬💻🧪
Excited to announce our latest publication: “Keeping it in the family: Using protein family templates to rescue low confidence AlphaFold2 models” where we explore plDDT variability in #AF2 models of @pfamdb.bsky.social
domains. doi.org/10.1093/bioa... 1/7
🧬 What's new in Pfam? Beta propellers uncovered through smart deduplication, fresh perspectives on haloarchaeal proteins, and more! Dive into our latest blog: xfam.wordpress.com/2024/12/09/p...
NAR graphical abstract: Pfam coverage Using AlphaFold to build new Pfam domains Use of deep learning to Increase coverage of UniProtKB Improved coverage of repeated domains
For the latest Pfam updates, have a look at our recently published paper: The Pfam protein families database: embracing AI/ML
t.co/8auCxw3mdj
InterPro release 103.0: 28th November 2024
Database updates: Pfam 37.1
1029 new entries containing: 1008 Pfam 2 NCBIfam 1 PIRSF 1 PANTHER 7 CDD
New features: Redesigned protein viewer Improved dataset browsing Streamlined website navigation Member database entry page updates
InterPro release 103.0 is live! 💻🧪
✨Update to Pfam 37.1
✨1029 new entries, including 1019 signatures from the Pfam (1008), NCBIfam (2), PIRSF (1), PANTHER (1), CDD (7) databases.
Have a look: ebi.ac.uk/interpro/
Pfam: collection of protein families and domains Content: Over 21,000 entries describing protein families, domains and repeats. Training available on the EMBL-EBI training platform
We’re delighted to have joined BlueSky to engage with the scientific community about protein families, protein domains and related data. The Pfam database is a large collection of protein families, domains and repeats.
