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Posts by Sabrina Green

She’s a 10 but the threshold for award is 12

1 month ago 1 0 0 0
Genomic epidemiology of Ukraine conflict-associated Klebsiella pneumoniae reveals the emergence of a high-risk clone with a hybrid virulence-resistance plasmid vulnerable to lytic phages As antimicrobial resistance continues to rise and the development of new antimicrobials lags, we face an urgent threat where routine infections could become life-threatening. Armed conflicts, like the Russian war on Ukraine, intensify this crisis by accelerating the emergence and spread of resistant organisms across regions and borders. Phage Support Ukraine (Phage Sp UKR) is a collaborative effort to provide phages targeting circulating pathogens in Ukraine for delivery of personalized phage therapies. Within this context, we received multidrug-resistant bacterial isolates belonging to a number of different species. We here focus on Klebsiella pneumoniae , the most concerning pathogen with regard to prevalence, virulence and antibiotic resistance. Among the K. pneumoniae isolates, we identified sequence types (ST) 39, 101, 147, 307 and 395, as well as a predominating clonal group—CG10146 (ST23 KL57), first detected in Moscow—carrying a hybrid virulence-resistance plasmid encoding NDM-1 and aerobactin. Over two years (2023–2025), this clonal group expanded and acquired pan-resistance. When tested in virulence assays, only one isolate (ST395) displayed hypervirulence in a Galleria mellonella though not in a mouse infection model. Several phages isolated from Ukrainian sewage were able to lyse these K. pneumoniae strains, including strains obtained from soldiers displaced in Belgium, Germany, and Latvia. Bacterial resistance was observed during in vitro testing. However, some phage-resistant isolates had mutations in virulence factors, including one that completely lost its hybrid plasmid, resulting in restored antibiotic susceptibility. Strategies like Phage Sp UKR are essential to prevent the selection, persistence, and global spread of these MDR clones. ### Competing Interest Statement The authors have declared no competing interest.

After 2 years of close collaboration with colleagues in #Kyiv, our work supporting a #phage therapy program in #Ukraine is now out as a preprint:

www.biorxiv.org/content/10.6...

3 months ago 8 3 0 0
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I think the #phages are spelling something.

Phage + bacterial droplets as a way to quantify infectious titer. This is work from Stefan Vermeulen from HO Gent. This is a salmonella phage infecting after 180 minutes.

The PMD4U platform with patented methodology.

3 months ago 7 2 1 0

Is there anyone here at one of the universities in Wellington, NZ, who would want to host me to give a talk around November 10th?

7 months ago 38 29 8 1
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Great talk from Rob Edwards. Lots of new #phage tools to play with. Scan the QR codes.

Also he has 5 year #postdoc positions below. Seems like a sufficient amount to get some good work done.

7 months ago 15 2 1 0
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Genomic resistance in historical clinical isolates increased in frequency and mobility after the age of antibiotics Antibiotic resistance is frequently observed shortly after the clinical introduction of an antibiotic. Whether and how frequently that resistance occurred before the introduction is harder to determin...

What was antibiotic resistance like before we ever used antibiotics? How did we change what antibiotic resistance genes looked like over 100 years?

Our paper looking at resistance genes from a century of NCTC historical isolates now out in mGen:
www.microbiologyresearch.org/content/jour...

7 months ago 208 88 9 12
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TAILΦRing the future of medicine: An interview with Dr. Sabrina Green on Phage Therapy 10.38105/spr.wsuotsq44q

Check out this #MIT #science policy review interview on #phage therapy.

Thanks for the interview.

sciencepolicyreview.pubpub.org/pub/a80dkjhz...

8 months ago 8 1 0 0
Abstract submission 2nd BSVoM symposium - BSVoM

Hello BSVoM Blueskyers,

Are you in need of some #phage, #phage therapy and other viruses of microbes conferences?!! 👁️👇🏽

🦠 BSVoM Symposium (Sept 12): Keynotes
from @jeanpaulpirnay.bsky.social and @antoniasagona.bsky.social and more!!

🗓️ Abstracts: Aug 8 | Reg: Sept 1

www.bsvom.be/en/abstract-...

8 months ago 7 5 0 1

Yeah let’s just let not do anything then.

8 months ago 0 0 0 0
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Successful phage therapy in a patient with prosthetic joint infection

Phage therapy in a patient with prosthetic join infection in Spain! Another sucessful treatment from the #EnBiVir #VLCphagehunters @i2sysbio.es and #EvolvingTherapeutics in collaboration with Dr. de la Villa #GregorioMarañon
@uv.es
@csic.es

www.sciencedirect.com/science/arti...

9 months ago 15 3 1 3
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Are you craving some #phage #phage therapy related talks?! Well check this out today! We discuss the 100 cases paper therapy and more!

9 months ago 6 0 1 0
PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Can phage treat infection AND vaccinate? We found that phage treatment protects mice against re-infection by the same pathogen. Out today in PNAS. @tailor-labs.bsky.social www.pnas.org/doi/10.1073/...

10 months ago 60 19 5 1

This is nice in mice. Have you looked in patient samples?

10 months ago 0 0 0 0

ChatGPT likes them

11 months ago 1 0 0 0

Check out this seminar about Archaeal viruses! Are they really from hell or just a hot place?!

11 months ago 1 0 0 0
https://doi.org/10.1093/nar/gkaf335 No description available

Explore the Bakta Web, a user-friendly platform enhancing the popular command line tool for fast bacterial genome annotation. No command line skills needed! PMID:40271661, Nucleic Acids Res 2025, @NAR_Open https://doi.org/10.1093/nar/gkaf335 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

11 months ago 5 3 0 0
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A digital photography dataset for Vaccinia Virus plaque quantification using Deep Learning - Scientific Data Scientific Data - A digital photography dataset for Vaccinia Virus plaque quantification using Deep Learning

Conceived by Félix d’Herelle, plaque assay remains the cornerstone of #Virology and #Microbiology. In our recent work, we bring it to the era of #AI by collating mobile photos benchmark and proposing an e2e baseline @casusscience.bsky.social @hzdr.bsky.social www.nature.com/articles/s41... 🧪

11 months ago 4 2 0 0
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Communicating the promise of phage therapy - Nature Microbiology Use social media, talks, blogs and podcasts to raise awareness about antimicrobial resistance and push for wider access to life-saving phage treatments, writes Sabrina Green.

Sabrina Green @motherofphage.bsky.social writes about her journey communicating the importance of life-saving phage treatments in the era of antimicrobial resistance.

#MicroSky 🦠

www.nature.com/articles/s41...

11 months ago 11 5 0 0
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Communicating the promise of phage therapy Nature Microbiology - Use social media, talks, blogs and podcasts to raise awareness about antimicrobial resistance and push for wider access to life-saving phage treatments, writes Sabrina Green.

Hello #phage Phriends enjoying bluer skies here.

Check out my write up below on science communication for #phage therapy.

rdcu.be/eiVYd

11 months ago 7 3 0 0
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Communicating the promise of phage therapy - Nature Microbiology Use social media, talks, blogs and podcasts to raise awareness about antimicrobial resistance and push for wider access to life-saving phage treatments, writes Sabrina Green.

Out now 👉 Communicating the promise of phage therapy

By Sabrina Green @motherofphage.bsky.social

Read it here:
rdcu.be/eiWDJ

www.nature.com/articles/s41...

11 months ago 7 5 0 0

Phish sticks

1 year ago 6 1 0 0
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Donate to Help Team BMI protect global food security at iGEM!, organized by iGEM BMI All stories start somewhere, and ours starts with Ahmed. Ahmed is … iGEM BMI needs your support for Help Team BMI protect global food security at iGEM!

Hi Friends,
I wanted to share a crowdfunder for this amazing Pakistani iGEM team looking to raise for their entrance fee expenses. Please share, and if you have the means to do so even a little donation would help. Let's get these biologists to the jamboree!

www.gofundme.com/f/help-team-...

1 year ago 10 9 2 0
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Check out this #phage game from @microbiologysociety.org. Insert the phages in the correct receptor and all the phages inside come out :)

1 year ago 9 1 0 0
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#Phage bacteria arms race be like

1 year ago 4 1 0 0

Could be a cool tattoo

1 year ago 2 0 0 0
JCI - Bacteriophage therapy for multidrug-resistant infections: current technologies and therapeutic approaches

New open access review on phage therapy current technologies and therapeutic approaches!

The only one you have to read! Very thorough overview.

JCI - Bacteriophage therapy for multidrug-resistant infections: current technologies and therapeutic approaches www.jci.org/articles/vie...

1 year ago 3 2 0 1
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JCI - Bacteriophage therapy for multidrug-resistant infections: current technologies and therapeutic approaches

Bacteriophage therapy for multidrug-resistant infections: current technologies and therapeutic approaches

www.jci.org/articles/vie...

1 year ago 2 2 0 0
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Why is it so hard to rewrite a genome? Synthetic biologists have the know-how and ambition to retool whole genomes. But the hidden complexity of biological systems continues to surprise them.

Synthetic biologists discuss with Nature why it’s so hard to write a genome. “We underestimated how complex biology is.” 🧪 🧬

1 year ago 138 38 1 3
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Check out our latest #phagetherapy review in Nature Reviews Methods Primers.

rdcu.be/d9H92

Happy to share a conceptual schematic for a “phrinter (phage printer)” 😊

Many thanks to all co-authors, editors and reviewers!

1 year ago 8 6 1 0
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taxMyPhage: Automated Taxonomy of dsDNA Phage Genomes at the Genus and Species Level | PHAGE Background: Bacteriophages are classified into genera and species based on genomic similarity, a process regulated by the International Committee on the Taxonomy of Viruses. With the rapid increase in...

🚀 Excited to share our new paper: taxMyPhage: Automated Taxonomy of dsDNA Phage Genomes at the Genus and Species Level 🦠🔬!

Big thanks to all collaborators, especially @milja001.bsky.social & Thomas Sicheritz-Pontén! 🙌

📄 www.liebertpub.com/doi/10.1089/...

1 year ago 26 9 1 2